PET/CT Imaging System

PET/CT成像系统

• 批准号: 7839712
• 负责人: William J. Jagust
• 金额: $ 189.64万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7839712
• 关键词: Animals; Biochemical Process; California; Charge; Clinical; Commit; Computer software; Conflict (Psychology); Contract Services; Cyclotrons; Data Analyses; Development; Ensure; Environment; Equipment; Extramural Activities; Failure; Foundations; Funding; Generations; Grant; Health; Human; Image; Imaging technology; Institution; Investigation; Laboratories; Laboratory Research; Maintenance; Manufacturer Name; Medical; Monitor; Neurosciences Research; Occupations; Positron-Emission Tomography; Process; Quality Control; Radiochemistry; Radioisotopes; Radiopharmaceuticals; Recording of previous events; Regulation; Request for Applications; Research; Research Infrastructure; Research Personnel; San Francisco; Scientist; Site; System; Training; Transportation; United States National Institutes of Health; Universities; cost; design and construction; experience; flexibility; human disease; instrument; operation; programs; protocol development; prototype; public health relevance

DESCRIPTION (provided by applicant): This application requests a PET/CT imaging system for a group of investigators at the University of California Berkeley (UCB), Lawrence Berkeley National Laboratory (LBNL), University of California San Francisco and the University of California Davis. Ten major users are supported by 10 R01s, 2 P01s and considerable additional NIH, federal and foundation grants for PET research. The group has used the existing LBNL research-dedicated PET camera for years, and has collaborated on issues related to funding, operations, data analysis, and subject transportation. However, the current camera is outdated, no longer supported by the manufacturer, and suffers from frequent and prolonged downtime related to failures and difficulty obtaining parts. The request is for a modern camera that will support both the primary application of neuroscience research as well as multiple other applications. The scanner is configured to provide optimal image acquisition and research flexibility but without expensive clinical options that are unnecessary for the research program. The environment is strong, with existing complementary equipment including a 1.5T MR system and a SPECT/CT system at LBNL and a 3T MR system on the UCB campus. A medical cyclotron at LBNL operated by a radiochemistry research group, produces a wide variety of radiopharmaceuticals for human and animal use. The research group also has a long history of excellence in PET and imaging technology and has experience with the design, construction, operation, and maintenance of prototype PET cameras as well as PET data analysis. Use of the instrument will be overseen by an operations group comprised of technical staff and scientists who are expert in software support/data analysis, radiochemistry and hardware support. This group will operate the scanner, provide quality control, monitor usage, and assure training of all users as well as compliance with human, animal, and radioisotope regulations. A users group will assist in the development of protocols and will provide the interface between the operations group and users. The institution (LBNL) has committed support for any necessary renovations in siting the instrument, and will operate a recharge facility for financial administration. Current usage is adequate to support the cost of operations, a service contract, and minimal staffing with a relatively modest hourly charge. The entire project will be overseen by an executive committee with responsibility for ensuring access, promoting the use of the instrument, managing conflicts, ensuring training, and generation of continued extramural support. PUBLIC HEALTH RELEVANCE: Imaging with positron emission tomography (PET) has reached a level of maturity that permits the investigation of a host of biochemical processes that are related to human health and may reveal the fundamental processes underlying human disease. This PET scanner will permit a group of investigators to continue their productive research, and will help to create jobs through the continuing manufacture of scanners in the US as well as the development and support of a scientific infrastructure that employs technical and scientific workers.

描述（由申请人提供）：本申请要求加利福尼亚大学伯克利分校（UCB），劳伦斯·伯克利国家实验室（LBNL），加利福尼亚大学旧金山大学和加利福尼亚大学戴维斯分校的一组调查员PET/CT成像系统。 10个主要用户得到10个R01，2个P01的支持，并提供相当多的NIH，联邦和基金会赠款的宠物研究。多年来，该小组使用了现有的LBNL研究专用宠物相机，并在与资金，运营，数据分析和主题运输有关的问题上进行了合作。但是，当前的摄像头已经过时，不再由制造商支持，并且遭受了与故障和难以获得零件有关的频繁且延长的停机时间。 该请求是对现代相机的要求，该相机将支持神经科学研究的主要应用以及其他多个应用程序。该扫描仪配置为提供最佳的图像获取和研究灵活性，但没有昂贵的临床选择，而这对于研究计划不需要。环境很强，现有的互补设备在内，包括1.5T MR系统和LBNL的SPECT/CT系统以及UCB校园的3T MR系统。由放射化学研究小组运营的LBNL的医疗回旋子，生产各种用于人类和动物的放射性药物。研究小组在PET和成像技术方面的卓越历史也很长，并且在原型PET摄像机的设计，构建，操作和维护以及PET数据分析方面具有经验。 该仪器的使用将由由技术人员和科学家组成的运营小组监督，他们是软件支持/数据分析，放射化学和硬件支持的专家。该小组将操作扫描仪，提供质量控制，监控使用情况，并确保对所有用户的培训以及遵守人，动物和放射性同位素法规。用户组将协助协议的开发，并将提供操作组与用户之间的接口。该机构（LBNL）已为该工具的任何必要的翻新提供了支持，并将为金融管理运营补给设施。当前的用法足以支持运营成本，服务合同以及相对适度的小时费用。整个项目将由执行委员会监督，负责确保访问，促进工具的使用，管理冲突，确保培训并产生持续的壁外支持。 公共卫生相关性：正电子发射断层扫描（PET）的成像已达到成熟水平，该水平允许研究与人类健康相关的一系列生化过程，并可能揭示了人类疾病的基本过程。该PET扫描仪将允许一组研究人员继续其生产性研究，并通过在美国的持续制造扫描仪以及对技术和科学工人的科学基础设施的发展和支持来帮助创造就业机会。