SPORE in Head and Neck Cancer

头颈癌中的孢子

• 批准号: 7488595
• 负责人: DONG M SHIN
• 金额: $ 227.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-23 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7488595
• 关键词: SPORE; Head; Neck; Cancer

DESCRIPTION (provided by applicant): The Emory University Winship Cancer Institute (Emory WCI) proposes to conduct a Specialized Program of Research Excellence (SPORE) for Head and Neck Cancer (HNC). The overall goal of the Emory WCI HNC SPORE is to improve prevention and treatment of head and neck cancer with emphasis on new discoveries, rapid translation to patients who are suffering, disability and morbidity caused by this disease. The SPORE program will consist of four (4) major translational research projects, two research cores, an administrative core, a developmental research program, and a career development program. The WCI HNC SPORE will use an interdisciplinary approach to meet its objectives by carrying out projects with coinvestigators in basic, translational, and clinical science. All projects will test hypotheses about biology, prevention, molecularly and nanotechnology driven novel therapeutic approaches. The four (4) main projects are: (1) Chemoprevention with Green Tea Polyphenon E and EGFR-TKIs in HNC; (2) Targeting Death Receptors-Mediated Apoptosis for HNC; (3) Development of Novel Curcumin Analogs for the Treatment of Head and Neck Cancer, (4) Biodegradable Nanoparticle Formulated Taxol for Targeted Therapy of HNC. Each project in our SPORE program is centered on clearly defined translational objectives including pilot clinical trials (project 1, Phase I Study of Chemoprevention; project 2, biomarker studies; project 3, phase 0 trial of EF24; project 4, phase 1b clinical study) that have close interaction with the cores. The two research cores (Specimen Resources and Pathology Core, Biostatistics and Data Management Core) will assist the main research projects, developmental research projects, and career developmental investigators in performing head and neck cancer translational research. The Administrative Core will provide scientific and financial oversight for the SPORE program. We also have a strong commitment of support including space, recruitment, shared resources and matching funds from the Emory Winship Cancer Institute, Emory University School of Medicine, Woodruff Health Science Center at Emory University, Georgia Cancer Coalition (GCC), and the Georgia Research Alliance (GRA). The Emory WCI HNC SPORE investigators will work closely together as a team to achieve the goals of the program and will also interact with investigators from HNC SPORES at other institutions and other research programs to improve outcomes for head and neck cancer patients.

描述（由申请人提供）：埃默里大学温希普癌症研究所 (Emory WCI) 提议针对头颈癌 (HNC) 开展一项卓越研究专门计划 (SPORE)。埃默里大学 WCI HNC SPORE 的总体目标是改善头颈癌的预防和治疗，重点是新发现、快速转化为因该疾病而遭受痛苦、残疾和发病的患者。 SPORE 计划将包括四 (4) 个主要转化研究项目、两个研究核心、一个行政核心、一个发展研究计划和一个职业发展计划。 WCI HNC SPORE 将采用跨学科方法，与基础科学、转化科学和临床科学领域的共同研究人员开展项目，以实现其目标。所有项目都将测试有关生物学、预防、分子和纳米技术驱动的新型治疗方法的假设。这四 (4) 个主要项目是： (1) HNC 中绿茶多酚 E 和 EGFR-TKI 的化学预防； (2) 针对HNC的死亡受体介导的细胞凋亡； (3) 开发用于治疗头颈癌的新型姜黄素类似物，(4) 用于 HNC 靶向治疗的可生物降解纳米颗粒配制的紫杉醇。我们的 SPORE 计划中的每个项目都以明确定义的转化目标为中心，包括试点临床试验（项目 1，化学预防的 I 期研究；项目 2，生物标志物研究；项目 3，EF24 的 0 期试验；项目 4，1b 期临床研究）与核心有密切的相互作用。两个研究核心（标本资源和病理学核心、生物统计学和数据管理核心）将协助主要研究项目、发展研究项目和职业发展研究人员进行头颈癌转化研究。行政核心将为 SPORE 计划提供科学和财务监督。我们还得到埃默里温希普癌症研究所、埃默里大学医学院、埃默里大学伍德拉夫健康科学中心、佐治亚癌症联盟 (GCC) 和佐治亚研究中心的坚定支持，包括空间、招募、共享资源和配套资金联盟（GRA）。埃默里大学 WCI HNC SPORE 研究人员将作为一个团队密切合作，以实现该计划的目标，并将与其他机构和其他研究项目的 HNC SPORES 研究人员进行互动，以改善头颈癌患者的治疗结果。