Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in Autism

自闭症患者的睡眠和昼夜节律障碍、大脑和神经行为发育

• 批准号: 10085599
• 负责人: Stewart H Mostofsky
• 金额: $ 28.87万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10085599
• 关键词: 12 year old; Acute; Adaptive Behaviors; Address; Adult; Affect; Area; Attention; Base of the Brain; Behavior; Behavioral; Biological; Biological Markers; Biometry; Brain; Child; Circadian Dysregulation; Clinical; Cognition; Cognitive; Data; Detection; Development; Developmental Disabilities; Diagnosis; Elements; Enrollment; Epidemiology; Etiology; Exhibits; Goals; Health behavior; Hour; Impairment; Institutes; Intellectual and Developmental Disabilities Research Centers; Intervention; Link; Literature; Machine Learning; Measurement; Measures; Mediating; Methodology; Methods; Modeling; Motor Activity; Outcome; Outcome Measure; Parents; Pattern; Phase; Phenotype; Population; Precision therapeutics; Preparation; Prevention; Procedures; Questionnaires; Reporting; Research; Research Project Grants; Resources; Rest; Role; Sample Size; Sampling; School-Age Population; Severities; Sleep; Sleep Disorders; Sleep disturbances; Statistical Models; Structure; Symptoms; Thick; Time; Universities; Work; Wrist; Youth; actigraphy; analytical method; autism spectrum disorder; autistic; autistic children; base; behavioral phenotyping; brain health; circadian; executive function; improved; improved outcome; indexing; innovation; innovative technologies; neurobehavioral; neuroimaging; novel; personalized intervention; sleep behavior; sleep onset; social; trait

PROJECT SUMMARY/ABSTRACT – RESEARCH COMPONENT The goal of this study entitled, “Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in Autism” is to examine how disturbed sleep and altered circadian rest/activity rhythms (RARs) affect brain development, cognitive and adaptive function, and symptom severity in children with autism. Disturbed sleep is highly prevalent among children with autism spectrum disorder (ASD); over 60% are estimated to exhibit frequent sleep disturbances, including delayed sleep onset, fragmented nighttime sleep, and early-morning waking. While typically viewed as a consequence of ASD, disturbed sleep may not only have acute effects on cognition, adaptive functioning, and behavioral disturbances in this population. Notably, while many studies have evaluated the relationship between disordered sleep and neuroimaging, and neuroimaging and ASD, no work, to our knowledge, has integrated these topics. Furthermore, rigorous comparison of sleep and RAR metrics via parent-report and actigraphy have not been conducted in ASD. For this project, we propose to address these gaps through refining how sleep/wake problems are assessed in children with ASD by applying novel statistical modeling to both objective (using actigraphy) and parent-report (using CSHQ) measures and examining how disturbed sleep and altered RARs might affect brain structure and function in children with ASD. We embed this project in the Kennedy Krieger Institute-Johns Hopkins University Intellectual and Developmental Disabilities Research Center (IDDRC), leveraging crucial resources in phenotypic assessment, neuroimaging, biostatistics, and behavioral preparation for procedures that are available through the Center. At the same time, this investigative team brings new statistical and epidemiologic expertise to Center Cores, to conduct this study in 200 children with and without ASD. Via this project, Center resources will be used to further integrate this population with 493 children with extant data (but not wrist actigraphy), establishing a large-well phenotyped population for Center research. This work will help to refine and inform clinical and prevention practices among children with disordered sleep and ASD, providing methodological advances in sleep characterization and etiology.

项目摘要/摘要 - 研究部分 这项研究的目的为“睡眠和昼夜节律障碍，大脑和神经行为的发育 在自闭症中”是检查睡眠和昼夜节律静止/活动节奏（RARS）的影响如何影响大脑 自闭症儿童的发育，认知和适应性功能以及症状严重程度。睡眠不安 自闭症谱系障碍儿童（ASD）非常普遍；估计超过60％的退出 经常睡眠障碍，包括延迟睡眠发作，夜间睡眠和早晨 醒来。虽然通常被视为ASD的结果，但睡眠不仅可能对 该人群中的认知，适应性功能和行为灾难。值得注意的是，许多研究 已经评估了睡眠和神经影像失调与神经影像和ASD之间的关系，否 据我们所知，工作已经整合了这些主题。此外，严格的睡眠和RAR比较 通过父母报告和行动摄影的指标尚未在ASD中进行。 对于这个项目，我们建议通过完善睡眠/唤醒问题来解决这些差距 通过将新颖的统计模型应用于客观（使用行为摄影）和 父母报告（使用CSHQ）措施并检查睡眠不足和改变的RAR可能会影响大脑 ASD儿童的结构和功能。我们将这个项目嵌入了肯尼迪·克里格学院 - 约翰斯 霍普金斯大学知识与发展障碍研究中心（IDDRC），利用关键 表型评估，神经影像学，生物统计学和行为准备的资源 可以通过中心获得。同时，这个调查团队带来了新的统计和 核心核心的流行病学专业知识，在200名患有和没有ASD的儿童中进行这项研究。通过这个 项目，中心资源将用于将该人群与493名儿童一起进一步融合，并提供额外的数据（但是 不是手腕行为），建立一个大井表型人群进行中心研究。这项工作将有所帮助 在睡眠和ASD的儿童中完善并告知临床和预防措施，提供 睡眠特征和病因的方法论进步。