Atopy, Leptin and Potential Biomarkers of Comorbid Obesity and Asthma in Inner-City Schoolchildren

内城学童中特应性、瘦素以及共病肥胖和哮喘的潜在生物标志物

• 批准号: 10083167
• 负责人: PERDITA PERMAUL
• 金额: $ 19.7万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10083167
• 关键词: Accounting; Age; Allergens; Allergic; Allergic inflammation; Area; Asthma; Award; Basophils; Biological Markers; Biology; Biometry; Body mass index; Center for Translational Science Activities; Child; Childhood Asthma; Chronic Disease; Clinical; Clinical Research; Clinical Sciences; Cohort Studies; Collection; Consent; Data; Dust; Educational Activities; Enrollment; Environment; Environmental Epidemiology; Environmental Exposure; Extrinsic asthma; Five-Year Plans; Frequencies; Funding; Goals; Home; Human; Infrastructure; Institution; Intervention; Intervention Studies; Knowledge; Laboratories; Learning; Leptin; Link; Literature; Measures; Mediating; Mediator of activation protein; Mentors; Mentorship; Minority Groups; Morbidity - disease rate; National Health and Nutrition Examination Survey; National Institute of Allergy and Infectious Disease; Obesity; Outcome; Overweight; Pediatric cohort; Phenotype; Physicians; Play; Population; Positioning Attribute; Prevalence; Public Health; Public Health Schools; Research; Research Personnel; Research Project Grants; Research Project Summaries; Research Training; Resources; Risk; Role; School-Age Population; Schools; Scientist; Serum; Students; Surface; Symptoms; Techniques; Time; Training; Translational Research; United States; United States National Institutes of Health; Universities; Work; aged; air sampling; airway inflammation; atopy; base; career; career development; clinical phenotype; cohort; comorbidity; effective therapy; elementary school; environmental allergen; epidemiology study; high body mass index; inner city; innovation; insight; leptin receptor; low socioeconomic status; mortality; multidisciplinary; novel; novel marker; obesity in children; patient oriented research; phenotypic data; potential biomarker; programs; receptor expression; recruit; skills; symposium; urban children

PROJECT SUMMARY Research: There is a growing body of literature showing an association between childhood obesity and asthma morbidity. For reasons not fully understood, overweight/obese children with asthma are at an increased risk for worse asthma, particularly those with lower socioeconomic status and living in inner-city areas. This proposal details a five-year plan to provide the candidate, Perdita Permaul, MD, with the training and expertise to evaluate the role body mass index plays in the relationship between allergic inflammation and asthma morbidity in an established cohort of inner-city children with asthma enrolled in the School Inner-City Asthma Study (PI: Phipatanakul). This important and unique study involves the collection of extensive allergic phenotypic and outcomes data and potential biomarkers linking these two chronic diseases. Moreover, she has included an innovative and novel translational piece to examine leptin receptor expression on human basophils across BMI percentiles and the role that leptin plays in basophil activation, uniting basophil biology with phenotypic and functional data. Candidate: Dr. Permaul's long-term goal is to become an independent clinical/translational NIH funded investigator focused on patient-oriented research in pediatric asthma, and more specifically, in studying the association between childhood obesity and asthma morbidity. In order to achieve this goal, her short-term career objectives are to obtain further didactic training in environmental epidemiology, clinical and translational research, advanced biostatistics, as well as practical skills in cohort building, exposure assessment, laboratory techniques and biomarker analysis. This will be accomplished with formal classes, fieldwork and collaborative work to learn how to recruit, consent, and maintain a cohort, benchwork, attendance at institutional/national conferences, and guidance from established mentors and a multidisciplinary advisory board with the relevant expertise. This will result in a unique combination of practical skills and scientific knowledge that will successfully position her for her first R01 application and an independent career as a physician-scientist. Environment: Dr. Permaul will perform her research training and career development activities at world- renowned major academic institutions. She will work under the mentorship of Dr. Phipatanakul, an expert in environmental epidemiology and asthma, in addition to an extraordinary team of researchers, including Drs. Wayne Shreffler, Carlos Camargo, and Brent Coull, who have committed their time, resources, and expertise to facilitate Dr. Permaul's career development and the successful completion of the proposed project. During this award period, Dr. Permaul will complete the Program in Clinical and Translational Science through the Harvard Clinical and Translational Science Center and formal coursework at the Harvard School of Public Health. The academic environment created by the mentor, the institution, Harvard University and its affiliates provides a fertile ground for learning and collaborating specific to her research.

项目摘要 研究：越来越多的文献表明儿童肥胖与 哮喘发病率。由于尚未完全理解的原因，超重/肥胖儿童患有哮喘 哮喘的风险增加，尤其是那些社会经济地位较低且生活在城市中的风险 区域。该建议详细介绍了为候选人Perdita Permaul，医学博士提供培训的五年计划 以及评估体重指数在过敏性炎症和 在学校内城内哮喘的既定群体中的哮喘发病率 哮喘研究（PI：Phipatanakul）。这项重要而独特的研究涉及广泛的过敏 表型和结果数据以及连接这两种慢性疾病的潜在生物标志物。而且，她有 包括一个创新和新颖的翻译作品，以检查人类嗜碱性粒细胞的瘦素受体表达 跨BMI百分位数以及瘦素在嗜碱性粒细胞激活中的作用，将嗜碱性粒细胞生物学与 表型和功能数据。 候选人：Permaul博士的长期目标是成为由临床/转化NIH资助的独立临床/转化 研究人员专注于小儿哮喘的以患者为导向的研究，更具体地说是研究 儿童肥胖与哮喘发病率之间的关联。为了实现这一目标，她的短期 职业目标是要在环境流行病学，临床和转化方面获得进一步的教学培训 研究，先进的生物统计学以及队列建设中的实践技能，暴露评估，实验室 技术和生物标志物分析。这将通过正规课程，现场工作和协作来完成 努力学习如何在机构/国家 既定导师和多学科顾问委员会的会议，指导 专业知识。这将导致实用技能和科学知识的独特组合 成功地将她定位为她的第一个R01申请，并且是医师科学家的独立职业。 环境：Permaul博士将在世界上进行她的研究培训和职业发展活动 - 著名的主要学术机构。她将在Phipatanakul博士的指导下工作，专家 环境流行病学和哮喘除了包括Drs在内的非凡研究人员之外。 韦恩·什里夫勒（Wayne Shreffler），卡洛斯·卡马戈（Carlos Camargo）和布伦特·库尔（Brent Coull）都花了时间，资源和专业知识 为了促进Permaul博士的职业发展，并成功完成了拟议项目。期间 在这个奖项期，佩尔莫尔博士将通过 哈佛大学临床和转化科学中心以及哈佛公立学院的正式课程 健康。由导师，机构，哈佛大学及其分支机构创建的学术环境 为学习和协作提供了肥沃的基础。