Neurobehavioral Assessment of Ethanol Seeking and Intake in the Rat
大鼠乙醇寻求和摄入的神经行为评估
基本信息
- 批准号:7661711
- 负责人:
- 金额:$ 33.98万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-09-30 至 2012-07-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAffectAlcohol consumptionAlcohol dependenceAlcoholsAmygdaloid structureAppetitive BehaviorBehaviorBehavioralBehavioral ModelBlood alcohol level measurementBrainCell NucleusCocaineComplexConsummatory BehaviorCuesDevelopmentDopamineEnvironmentEthanolEthanol dependenceFailureFutureGlutamatesGoalsHumanIndividualIntakeLearningLesionMaintenanceModelingMotorNucleus AccumbensPathway interactionsPerformancePharmaceutical PreparationsPharmacotherapyPhasePrefrontal CortexProcessPsychological reinforcementPublishingRattusRegulationReinforcement ScheduleResearchResearch PersonnelResourcesRoleSelf AdministrationSelf-AdministeredSiteSpecificityStressStructureSucroseVentral Tegmental Areaaddictionalcohol availabilityalcohol reinforcementalcohol seeking behaviorbinge drinkingdrinkingdrug of abuseinnovationmotivated behaviorneural circuitneurobehavioralneurochemistryprogramspsychostimulantreinforcerresponse
项目摘要
DESCRIPTION (provided by applicant): Alcohol acts as a potent reinforcer in humans and in rats, and the behaviors directly involved in alcohol use can be thought of as "goal-directed", involving two distinct phases: 1) the seeking or procurement of a particular resource (appetitive behaviors), and 2) the actual direct interactions with that resource (consummatory behaviors). This project utilizes an innovative behavioral model developed to separate the initial behavior required to obtain access to alcohol from the actual alcohol self-administration. Using this model, rats drink alcohol in the 1.0 g/kg range in <6 minutes, producing pharmacologically relevant blood alcohol concentrations (40-90mg%). Moreover, we have demonstrated that this model can identify drugs that specifically affect either the seeking or the drinking component of behavior while having little to no effect on the other component of alcohol-motivated responding. Thus, this approach provides a unique opportunity to examine the factors that independently and/or cooperatively affect the seeking and consumption of alcoholic beverages. The proposed studies systematically inactivate extremely localized neuroanatomical structures postulated to be involved in alcohol-seeking and intake, and then manipulate specific neurochemical function within these regions to dissect the neurocircuitry and neurochemistry underlying alcohol-motivated behavior. Overall, the project will: 1) assess alcohol-motivated behaviors where the preponderance of research on drug-seeking has been on other drugs of abuse; 2) focus on relatively discrete brain structures where many approaches necessitate less anatomical specificity; 3) examine alcohol vs. sucrose-reinforced responding to account for the regulation of behavior that is common to palatable, caloric goal substances; 4) lay the groundwork for the extension of the examination of binge drinking to the study of alcohol dependence; and 5) procedurally separate alcohol-seeking from drinking to attempt to identify the neuroanatomical and neurochemical substrates specific and common to these behaviors. The findings from this project will inform our basic understanding of the neural circuitry underlying alcohol-motivated behavior and determine whether or not this is a common reinforcement/addiction circuit or distinct to alcohol reinforcement. Importantly, these findings will also lay the groundwork for future pharmacotherapy development that can target an individual's specific dysregulation of seeking/initiation of drinking and/or failure to control drinking once begun.
描述(由申请人提供):酒精对人类和大鼠来说是一种有效的强化剂,直接涉及酒精使用的行为可以被认为是“目标导向的”,涉及两个不同的阶段:1)寻求或获得特定资源(食欲行为),以及 2)与该资源的实际直接交互(完成行为)。该项目利用了一种创新的行为模型,将获得酒精所需的初始行为与实际的酒精自我管理分开。使用该模型,大鼠在 6 分钟内饮用 1.0 g/kg 范围内的酒精,产生药理学相关的血液酒精浓度 (40-90mg%)。此外,我们已经证明,该模型可以识别专门影响行为中的寻求或饮酒部分的药物,而对酒精引发的反应的其他部分几乎没有影响。因此,这种方法提供了一个独特的机会来检查独立和/或合作影响酒精饮料的寻找和消费的因素。拟议的研究系统地灭活了假定与酒精寻求和摄入有关的极其局部的神经解剖结构,然后操纵这些区域内的特定神经化学功能,以剖析酒精诱发行为背后的神经回路和神经化学。总体而言,该项目将:1)评估酒精引发的行为,其中寻求药物的研究主要集中在其他滥用药物上; 2)关注相对离散的大脑结构,其中许多方法需要较少的解剖特异性; 3)检查酒精与蔗糖强化反应,以解释可口的、热量目标物质常见的行为调节; 4)为将酗酒检查扩展到酒精依赖研究奠定基础; 5)在程序上将酗酒与饮酒分开,以尝试识别这些行为特有且常见的神经解剖学和神经化学底物。该项目的研究结果将为我们提供对酒精诱发行为背后的神经回路的基本理解,并确定这是否是常见的强化/成瘾回路或与酒精强化不同。重要的是,这些发现也将为未来药物治疗的发展奠定基础,该药物治疗可以针对个体对寻求/开始饮酒的特定失调和/或一旦开始饮酒就无法控制的情况。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CRISTINE L CZACHOWSKI其他文献
CRISTINE L CZACHOWSKI的其他文献
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{{ truncateString('CRISTINE L CZACHOWSKI', 18)}}的其他基金
Targeting computation in prefrontal cortex to improve decision-making and reduce compulsive drinking in rodent models.
针对前额皮质的计算,以改善啮齿动物模型中的决策并减少强迫性饮酒。
- 批准号:
10277796 - 财政年份:2021
- 资助金额:
$ 33.98万 - 项目类别:
Targeting computation in prefrontal cortex to improve decision-making and reduce compulsive drinking in rodent models.
针对前额皮质的计算,以改善啮齿动物模型中的决策并减少强迫性饮酒。
- 批准号:
10675561 - 财政年份:2021
- 资助金额:
$ 33.98万 - 项目类别:
Neurobehavioral Assessment of Ethanol Seeking and Intake in the Rat
大鼠乙醇寻找和摄入的神经行为评估
- 批准号:
7322752 - 财政年份:2007
- 资助金额:
$ 33.98万 - 项目类别:
Neurobehavioral Assessment of Ethanol Seeking and Intake in the Rat
大鼠乙醇寻找和摄入的神经行为评估
- 批准号:
7503393 - 财政年份:2007
- 资助金额:
$ 33.98万 - 项目类别:
Neurobehavioral Assessment of Ethanol Seeking and Intake in the Rat
大鼠乙醇寻找和摄入的神经行为评估
- 批准号:
8112588 - 财政年份:2007
- 资助金额:
$ 33.98万 - 项目类别:
Neurobehavioral Assessment of Ethanol Seeking and Intake in the Rat
大鼠乙醇寻求和摄入的神经行为评估
- 批准号:
7900413 - 财政年份:2007
- 资助金额:
$ 33.98万 - 项目类别:
Drug Treatment of Ethanol Seeking in Rat and Monkey
大鼠和猴子乙醇寻求的药物治疗
- 批准号:
7057318 - 财政年份:2003
- 资助金额:
$ 33.98万 - 项目类别:
Drug Treatment of Ethanol Seeking in Rat and Monkey
大鼠和猴子乙醇寻求的药物治疗
- 批准号:
6890366 - 财政年份:2003
- 资助金额:
$ 33.98万 - 项目类别:
Drug Treatment of Ethanol Seeking in Rat and Monkey
大鼠和猴子乙醇寻求的药物治疗
- 批准号:
6744813 - 财政年份:2003
- 资助金额:
$ 33.98万 - 项目类别:
Drug Treatment of Ethanol Seeking in Rat and Monkey
大鼠和猴子乙醇寻求的药物治疗
- 批准号:
6555572 - 财政年份:2003
- 资助金额:
$ 33.98万 - 项目类别:
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