Phase 2 Kp-10 for Dopamine Agonist Intolerant Hyperprolactinemia IND 74,977

多巴胺激动剂不耐受高催乳素血症 2 期 Kp-10 IND 74,977

• 批准号: 10116170
• 负责人: Stephanie Beth Seminara
• 金额: $ 33.81万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10116170
• 关键词: Phase; Kp; 10; Dopamine; Agonist; Phase; Kp; 10; Dopamine; Agonist

Abstract Hyperprolactinemia is caused by pituitary tumors and pharmacologic or pathologic interruption of dopaminergic pathways. Elevated prolactin levels can also cause endocrine dysfunction at multiple levels of the reproductive cascade including hypogonadotropic hypogonadism, irregular menstruation, erectile dysfunction, infertility and bone loss. Recent data suggests that hyperprolactinemia causes reduced kisspeptin expression, which then leads to reductions in GnRH secretion, and hypogonadotropic hypogonadism. In mice, peripheral kisspeptin administration restores GnRH secretion, gonadotropin release, and ovarian cycles. In human patients with hyperprolactinemia (Preliminary Data), exogenous kisspeptin administration also restores gonadotropin secretion. Thus, this application explores the use of exogenous pulsatile kisspeptin as a therapeutic alternative for patients with hyperprolactemia who are intolerant to current therapies.

抽象的 高泌乳素血症是由垂体肿瘤以及药理学或病理中断引起的 多巴胺能途径。催乳素水平升高也会引起多个级别的内分泌功能障碍 生殖级联反应，包括性腺功能低下，月经不规则，勃起 功能障碍，不育和骨质流失。最近的数据表明高泌乳素血症会导致降低 接吻肽的表达，然后导致GNRH分泌减少和降低性发育不良 性腺功能不全。在小鼠中，外围亲吻肽给药恢复了GNRH分泌，促性腺激素释放， 和卵巢周期。在人类高泌乳素血症（初步数据）的人类患者中，外源性吻肽 管理还恢复了促性腺激素分泌。因此，此应用程序探讨了外源的使用 搏动性亲吻蛋白作为不宽容患者的治疗替代品 当前疗法。