New Jersey Alliance for Clinical Translational Science: NJ ACTS

新泽西临床转化科学联盟：NJ ACTS

基本信息

批准号：
10115156
负责人：
Reynold Alexander Panettieri
金额：
$ 464.82万
依托单位：
RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-03-11 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10115156
关键词：
AIDS/HIV problem Address Affect Age Asian Indian Behavioral Biometry Child Chronic Disease Clinical Clinical Research Clinical Sciences Clinical Trials Clinical Trials Design Cohort Studies Collaborations Communities Cuban Databases Dental Development Diagnosis Diagnostic Discipline of Nursing Disease Management Diverse Workforce Elderly Electronic Health Record Evaluation Fluorescent in Situ Hybridization Fostering Foundations Government Growth Health Health Insurance Portability and Accountability Act Health Sciences Health system Healthcare Hospitals Image Improve Access Individual Industry Informatics Infrastructure Institutes Institutional Review Boards Intervention Investigation Investments Laboratories Leadership Life Style Link Location Longevity Low income Machine Learning Medicaid Medical Mentors Methodology Methods Minority Minority Groups Mission Muslim population group Neighborhood Health Center New Jersey Not Hispanic or Latino Ontology Oral health Outpatients Parents Participant Pathogenesis Patient Recruitments Perception Population Population Density Precision therapeutics Prediction of Response to Therapy Process Public Health Public Health Schools Recording of previous events Research Research Personnel Research Training Resources School Nursing Science Solid South Asian Special Populations Research Substance abuse problem Technology Therapeutic Intervention Training Translational Research Universities Vision Workforce Development analytical tool base biomarker discovery career development catalyst clinical care clinical database clinical investigation cognitive neuroscience cohesion community based research community engagement disease heterogeneity ethnic diversity ethnic minority population experience follower of religion Jewish improved industry partner innovation interdisciplinary approach logarithm medical schools member natural language next generation novel novel strategies population health preventive intervention programs racial diversity racial minority recruit relating to nervous system research clinical testing response severe mental illness skills success tool translational scientist treatment response trial design

项目摘要

Contact PD/PI: Panettieri, Reynold Alexander Project Summary/Abstract Overview Coordinated by Rutgers Biomedical and Health Sciences (RBHS), the New Jersey Alliance for Clinical and Translational Science (NJ ACTS) comprises a consortium with Rutgers and Princeton Universities (PU), NJ Institute for Technology (NJIT), medical, nursing, dental and public health schools, hospitals, community health centers, outpatient practices, industry, policymakers and health information exchanges. All Alliance universities and affiliates have provided substantial resources and contributed to the planning, development and leadership of the consortium. With access to ~7 million people, NJ ACTS serves as a ‘natural laboratory’ for translational and clinical research. With a state population of ~9 million, New Jersey ranks 11th in the US, 1st in population density and higher than average in racial and ethnic diversity. Surprisingly, NJ has no CTSA Hub to coordinate translational and clinical research. Our CTSA Hub focuses on two overarching themes: the heterogeneity of disease pathogenesis and response to treatment, and the value of linking large clinical databases with interventional clinical investigations to identify cause-and-effect and predict therapeutic responses. NJ ACTS will provide: innovative approaches to link information from large databases and electronic health records to inform clinical trial design, execution and analysis; and novel platforms for biomarker discovery using fluorescence in situ hybridization and machine learning to identify unique neural signatures of chronic illness. NJ ACTS will access a large health system with significant member diversity; a rich legacy of community engagement and community-based research platforms; and proven approaches to enhance workforce development in clinical research. With a substantial investment in streamlining research administration and IRB practices at Rutgers and with the inception of NJ ACTS, there exists an unparalleled opportunity for logarithmic growth in clinical research in New Jersey. To build our capacity for participant and clinical interactions as a CTSA Hub, the newly established Trial Accelerator and Recruitment Office will coordinate feasibility assessment, implementation, recruitment, and evaluation of clinical studies. Additionally, our organization of five clinical research units into a cohesive network provides extraordinary expertise in strategic locations to enhance participant recruitment from diverse communities with a particular focus on: children; the elderly; those with serious mental illness or substance abuse issues; low-income individuals served by Medicaid; those with HIV/AIDS; and people of all ages who are minorities, underserved, and victims of health and environmental disparities. With a history of collaboration, partners and affiliates share unique skills, expertise, training and mentoring capabilities that will be greatly amplified within the infrastructure of a CTSA Hub. Princeton and NJIT, without medical schools or hospital affiliates, seeks collaboration with Rutgers to provide clinical research platforms; Rutgers seeks the PU and NJIT expertise in novel informatics platforms, expertise in natural language and ontology, machine learning and cognitive neurosciences. Together NJ ACTS will provide an alliance that will catalyze clinical research and training across New Jersey to improve population health and contribute to the CTSA Consortium. In this revised application, the overall themes remain unchanged but Cores leadership and direction has been markedly refined. Page 337 Project Summary/Abstract Contact PD/PI: Panettieri, Reynold Alexander New Jersey Alliance for Clinical and Translational Science (NJ ACTS)

联系人 PD/PI：Panettieri、Reynolds Alexander 项目概要/摘要概述由罗格斯大学生物医学和健康科学 (RBHS)、新泽西州临床和健康联盟协调转化科学 (NJ ACTS) 由新泽西州罗格斯大学和普林斯顿大学 (PU) 组成的联盟理工学院 (NJIT)、医疗、护理、牙科和公共卫生学校、医院、社区卫生中心、门诊诊所、行业、政策制定者和健康信息交流。及其附属机构提供了大量资源并为规划、开发和领导做出了贡献 NJ ACTS 拥有约 700 万人的资源，是转化的“天然实验室”。新泽西州人口约 900 万，在美国排名第 11，人口排名第 1。令人惊讶的是，新泽西州没有 CTSA 中心来协调。我们的 CTSA 中心专注于两个首要主题：疾病发病机制和治疗反应，以及将大型临床数据库与旨在确定因果关系并预测治疗反应的介入性临床研究 NJ ACTS 将进行。提供：将大型数据库和电子健康记录中的信息联系起来的创新方法，以提供信息临床试验设计、执行和分析；以及利用荧光发现生物标志物的新平台 NJ ACTS 将利用原位杂交和机器学习来识别慢性疾病的独特神经特征。获得具有显着成员多样性的大型卫生系统；以及社区参与的丰富遗产；基于社区的研究平台；以及增强临床劳动力发展的行之有效的方法罗格斯大学在简化研究管理和 IRB 实践方面投入了大量资金。随着 NJ ACTS 的启动，临床治疗存在着无与伦比的对数增长机会为了建设我们作为 CTSA 中心的参与者和临床互动的能力，新成立了设立试验加速器和招募办公室将协调可行性评估、实施、此外，我们将五个临床研究单位组织成一个。凝聚力网络在战略地点提供非凡的专业知识，以加强参与者的招募不同的社区，特别关注：儿童；患有严重精神疾病的人；药物滥用问题；医疗补助服务的低收入人群；以及艾滋病毒/艾滋病患者；少数民族、服务不足以及健康和环境差异的受害者。协作、合作伙伴和附属机构共享独特的技能、专业知识、培训和指导能力，这将无需医学院或新泽西理工学院，即可在普林斯顿大学和新泽西理工学院的基础设施内得到极大的扩展。医院附属机构寻求与罗格斯大学合作提供临床研究平台；和 NJIT 在新型信息学平台、自然语言和本体、机器学习方面的专业知识 NJ ACTS 将共同建立一个联盟，以促进临床研究和认知神经科学。新泽西州各地的培训，以改善人口健康并为 CTSA 联盟做出贡献。应用程序中，总体主题保持不变，但核心领导力和方向已明显细化。第337页项目概要/摘要联系人 PD/PI：Panettieri、Reynolds Alexander 新泽西临床和转化科学联盟 (NJ ACTS)