Mechanisms of Rapid Modulation of Auditory Responsiveness

听觉反应快速调节机制

• 批准号: 10055961
• 负责人: David McCormick
• 金额: $ 31.34万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10055961
• 关键词: Affect; Arousal; Attention; Auditory; Auditory area; Auditory system; Axon; Behavior; Behavioral; Brain; Caliber; Cells; Disease; Frequencies; Hippocampus (Brain); Individual; Inferior Colliculus; Injury; Knowledge; Measures; Medial; Medial geniculate body; Membrane Potentials; Methodology; Monitor; Movement; Neurons; Pathway interactions; Pattern; Property; Pupil; Recovery; Recovery of Function; Role; Signal Transduction; Slow-Wave Sleep; Structure; Synapses; Synaptic Potentials; System; Testing; Therapeutic; Time; Variant; Walking; Width; alertness; auditory processing; cholinergic; design; extracellular; hearing impairment; neuroregulation; noradrenergic; normal hearing; optogenetics; presynaptic; receptive field; response; sound

Summary How do rapid variations of the waking state influence central auditory responses and what is the role of noradrenergic and cholinergic systems? The central hypothesis that we wish to examine is “Rapid modulation of the waking state result from variations in activity of the noradrenergic and cholinergic pathways and occur along a continuum from: 1) reduced responses owing to cortical/subcortical spontaneous slow rhythms/low frequency cell and network burst firing during low arousal, 2) quiescent but accurately responsive networks during intermediate alertness, and 3) reduced responsiveness during high arousal or walking owing to high levels of both excitatory and inhibitory spontaneous activity. This is a timely topic, given that modulation of auditory responses and processing is important not only to normal hearing, but also in the recovery of function following damage or disease. Here we will test our central hypothesis (stated above) by performing extracellular unit and whole cell (synaptic) recordings from auditory cortical neurons and related subcortical structures (medial geniculate, inferior colliculus) during precisely measured variations in the waking state along with monitoring and manipulating the the activity of ascending cholinergic and noradrenergic pathways. Together, these results will yield a significant increase in our understanding of the cellular and network mechanisms of both normal, and recovery, of auditory cortical and subcortical function.

概括 清醒状态的快速变化如何影响中心听觉的反应？ 去甲肾上腺素和胆碱能系统？我们希望检查的中心假设是“快速调制 呼吸状态是由于去甲肾上腺素能和胆碱能途径的活性变化而导致的 沿着以下连续：1）由于皮质/皮质下慢速节奏/低的响应减少 频率电池和网络爆发在低唤醒期间，2）静态但准确响应的网络 在中间警报期间，3）在高唤醒或步行时降低了响应能力 兴奋性和抑制性的赞助活性。考虑到听觉的调制，这是一个及时的话题 响应和处理不仅对正常听力，而且对功能的恢复很重要 损害或疾病。在这里，我们将通过执行细胞外单元和 来自听觉皮质神经元和相关皮层结构（内侧）的全细胞（突触）记录 在清醒状态的精确测量变化以及监测和监测和监测和监测期间 操纵上升的胆碱能和去甲肾上腺素能途径的活性。这些结果将在一起 我们对正常的细胞和网络机制的理解显着增加 恢复，听觉皮质和皮层功能。

项目成果

Decision-making dynamics are predicted by arousal and uninstructed movements.

决策动态是通过唤醒和无指导的运动来预测的。

• DOI: 10.1016/j.celrep.2024.113709
• 发表时间: 2024
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Hulsey,Daniel;Zumwalt,Kevin;Mazzucato,Luca;McCormick,DavidA;Jaramillo,Santiago
• 通讯作者: Jaramillo,Santiago