Prenatal Sleep Health, Cortisol, and Gestational Weight Gain

产前睡眠健康、皮质醇和妊娠期体重增加

基本信息

批准号：
10066114
负责人：
Christine Hotaru Naya
金额：
$ 4.55万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-15 至 2022-08-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10066114
关键词：
Attention Behavior Behavioral Behavioral Research Child Child Health Clinical Counseling Data Deposition Development Dimensions Enrollment Environmental Risk Factor Exercise Faculty Family health status Fatty acid glycerol esters Fellowship Female of child bearing age First Pregnancy Trimester Funding Future Goals Health behavior Healthy Eating Hispanics Hydrocortisone Individual Intervention Late pregnancy Life Link Literature Low income Maternal Health Maternal and Child Health Mediating Mentorship Metabolic Metabolic syndrome Minority Monitor Mothers Nature Obesity Outcome Overweight Pattern Persons Physical activity Physiological Population Pregnancy Pregnant Women Prenatal care Principal Investigator Public Health Questionnaires Recommendation Reporting Research Risk Risk Factors Salivary Sampling Scientist Sleep Sleep Disorders Sleep Wake Cycle Sleep disturbances Third Pregnancy Trimester Time United States United States National Institutes of Health Weight Weight Gain Woman adequate sleep adverse birth outcomes alertness cardiovascular disorder risk circadian cohort environmental stressor gestational weight gain healthy pregnancy hypothalamic-pituitary-adrenal axis improved nutrition pregnant prenatal psychobiologic sleep health social stressor socioeconomic disadvantage trend

项目摘要

PROJECT SUMMARY/ABSTRACT Excessive gestational weight gain (GWG) significantly increases the risk of adverse birth outcomes and long- term maternal and child health issues. This is a significant public health concern, because over half of women of child-bearing age in the United States are overweight or obese, and these rates are disproportionately higher in minority and socioeconomically disadvantaged women. Despite efforts in the last 10 years to curtail excessive GWG rates, prenatal weight gain counseling and clinical interventions aimed at increasing physical activity and promoting healthy eating have led to inconsistent results, especially among low-income minority mothers. Thus, there is a need to identify alternative modifiable predictors of excessive GWG in minority women to improve the current prenatal care recommendations for GWG. Although more than 75% of women report sleep problems during pregnancy, and poor sleep is a putative risk factor for obesity in non-pregnant populations, sleep has consistently received less attention in prenatal weight gain interventions. However, current literature is limited by their cross-sectional nature, which does not permit examination of the effects of change in sleep health dimensions (i.e. duration, continuity, alertness, quality, and timing) during pregnancy or whether the relationship between sleep health and GWG differ by trimester. Furthermore, exploration of physiological mechanisms that link sleep health and GWG, such as the hypothalamic-pituitary-adrenal (HPA) axis and its by-product cortisol, is still lacking in pregnant populations. The overall goal of this study is to examine both population-level (between-person) and day-level (within-person) associations among sleep health, diurnal cortisol patterns, and GWG throughout pregnancy. This project will leverage data from 750 pregnant women enrolled in the NIH-funded Maternal and Developmental Risks from Environmental and Social Stressors (MADRES) Study (NIH P50ES026086) and a sample of 65 pregnant women from the real-time personal monitoring sub-study in MADRES. The proposed study will elucidate prenatal sleep health as an important factor that informs weight gain trends in minority mothers. Thus, findings will help identify sleep health as a target behavior for future excessive GWG interventions. This fellowship will allow me to receive mentorship from interdisciplinary faculty and contribute to my long-term goal of becoming a Principal Investigator and research scientist who integrates psychobiological and behavioral research under a public health umbrella to improve maternal, child, and family health outcomes.

项目摘要/摘要过度妊娠体重增加（GWG）显着增加了不良出生结果的风险和长期定期母亲和儿童健康问题。这是一个重大的公共卫生问题，因为超过一半的妇女美国承重年龄超重或肥胖，这些速率不成比例地更高少数民族和社会经济处于弱势妇女。尽管过去十年来努力减少过度 GWG率，产前体重增加咨询和临床干预措施，旨在增加体育锻炼和促进健康的饮食导致了不一致的结果，尤其是在低收入少数族裔母亲中。因此，有必要确定少数族裔女性过度GWG的替代可修改预测因素以改善 GWG当前的产前护理建议。尽管超过75％的妇女在怀孕期间报告睡眠问题，而睡眠不良是假定的风险非妊娠种群中肥胖的因素，睡眠始终受到产前体重的关注较少获得干预措施。但是，当前文献受其横断面的限制，这不允许检查睡眠健康维度变化的影响（即持续时间，连续性，警觉性，质量，和时间安排）怀孕期间或睡眠健康与GWG之间的关系是否因三个月而异。此外，探索将睡眠健康和GWG联系起来的生理机制，例如下丘脑 - 垂体 - 肾上腺（HPA）轴及其副产品皮质醇仍然缺乏怀孕的人群。这项研究的总体目标是检查人口级别（人际关系）和日间（人际关系）整个怀孕期间，睡眠健康，昼夜皮质醇模式和GWG之间的关联。这个项目将利用来自NIH资助的母亲和发育风险的750名孕妇的数据环境和社会压力源（MADRES）研究（NIH P50ES026086）和65名孕妇样本从Madres的实时个人监控子研究。拟议的研究将阐明产前睡眠健康是少数族裔母亲体重增加趋势的重要因素。因此，发现将有助于识别睡眠健康是未来过度GWG干预措施的目标行为。这个奖学金可以让我收到跨学科教师的指导，并为成为首席研究员的长期目标做出了贡献和研究科学家，他们在公共卫生伞下整合心理生物学和行为研究改善产妇，儿童和家庭健康成果。