Thalamocortical and corticocortical mechanisms for sleep-dependent visual learning

睡眠依赖性视觉学习的丘脑皮质和皮质机制

基本信息

批准号：
10058282
负责人：
SARA J ATON
金额：
$ 37.78万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-12-15 至 2022-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10058282
关键词：
Affect Animals Area Behavioral Brain Chemosensitization Cognition Communication Complex Data Dementia Discrimination Discrimination Learning Electrophysiology (science)Exposure to Feedback Genetic Transcription Hour Impaired cognition Individual Instruction Intervention Lateral Geniculate Body Lead Learning Link Measures Memory Mental Depression Mental disorders Mus Nature Neurons Opsin Pattern Periodicity Phase Play Population Process Response to stimulus physiology Role Schizophrenia Sensory Sleep Sleep Deprivation Stimulus Synapses Synaptic plasticity Testing Thalamic structure Translations V1 neuron Visual Wakefulness Work area striata autism spectrum disorder behavioral response brain metabolism computerized tools experience experimental study genetic approach in vivo insight long term memory memory consolidation memory recognition neural circuit neuroregulation non rapid eye movement novel optogenetics response visual learning visual stimulus

项目摘要

Project summary: Consolidating transient sensory experiences into long-lasting memories is a fundamental function of the brain, linked to synaptic plasticity. The importance of sleep for promoting this process, and the disruptive effect of sleep deprivation on it, have been appreciated for nearly a century. However, it remains unclear how sleep-associated changes in the activity of specific brain circuits contribute to sensory plasticity. Using a combination of longitudinal recordings of neuronal activity in freely-behaving mice, recently-developed optogenetic strategies, novel computational tools for characterizing network activity patterns, we will test the necessity and sufficiency of sleep-associated patterns of thalamocortical activity in consolidating a simple form of experience dependent plasticity. We will test the hypothesis that coherent firing during network oscillations unique NREM sleep plays a causal role in promoting plasticity between the thalamic lateral geniculate nucleus (LGN) and the primary visual cortex (V1) following presentation of a novel visual stimulus. Here we will selectively manipulate cortical, thalamocortical and corticothalamic neuronal populations in a state specific manner. We will measure both response changes in individual V1 and LGN neurons to the presented stimulus, and behavioral responses to the presented stimulus in the context of a visual discrimination task. We will test whether neurons that are selectively responsive to the visual stimulus play a critical role in guiding network activity patterns during subsequent sleep, acting as an instructive mechanism for circuit plasticity. Finally, we will test whether following visual experience, sleep-dependent communication between V1 and the perirhinal cortex (essential for visual recognition memory) is responsible sleep-dependent discrimination learning.

项目摘要：将瞬态感官体验整合到长期的记忆中是一个基本大脑的功能，与突触可塑性有关。睡眠对于促进这一过程的重要性，以及睡眠剥夺对其的破坏性影响，已近一个世纪受到赞赏。但是，它仍然是尚不清楚特定脑电路活性的睡眠相关变化如何导致感觉可塑性。使用自由行为的小鼠中神经元活动的纵向记录的结合，最近开发光遗传策略，用于表征网络活动模式的新型计算工具，我们将测试综合形式的丘脑皮质活性的睡眠相关模式的必要性和充分性经验依赖性可塑性。我们将测试网络振荡期间连贯触发的假设独特的NREM睡眠在促进丘脑外侧核之间的可塑性方面起着因果作用（LGN）和主要的视觉皮层（V1）出现了新的视觉刺激。在这里，我们将有选择地以状态特异性方式操纵皮质，丘脑皮质和皮质丘脑神经元种群。我们将测量单个V1和LGN神经元对提出的刺激的响应变化以及行为在视觉歧视任务的背景下，对提出的刺激的响应。我们将测试神经元是否对视觉刺激有选择性地响应的，在指导网络活动模式中起着至关重要的作用随后的睡眠，充当电路塑性的指导性机制。最后，我们将测试是否遵循视觉体验，v1和周围皮质之间的睡眠依赖性交流（对于视觉至关重要识别记忆是负责任的睡眠依赖歧视学习。