Administrative Core

行政核心

• 批准号: 10062144
• 负责人: MARY F PAINE
• 金额: $ 31.73万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10062144
• 关键词: Address; Budgets; Cannabis; Clinical; Collaborations; Communication; Communities; Data; Decision Making; Discipline; Drug Interactions; Drug Kinetics; Educational workshop; Ensure; Evaluation; Goldenseal; Green tea; Human; In Vitro; Informatics; Institution; International; Leadership; Logistics; Methodology; Methods; Mission; Mitragyna; Monitor; Natural Product Drug; Natural Products; Outcome; Outreach Research; Pharmaceutical Preparations; Pharmacology; Productivity; Public Health; Publications; Research; Research Activity; Research Personnel; Role; Running; Safety; Sampling; Source; Structure; Support System; Testing; Thinness; Time; Translating; Translations; United States National Institutes of Health; Update; Visit; Work; clinically significant; cohesion; cost effective; data warehouse; design; improved; innovation; inter-institutional; meetings; member; new technology; outreach; programs; success; symposium; web site

PROJECT SUMMARY OF THE ADMINISTRATIVE CORE Our thriving Center of Excellence for Natural Product Drug Interaction Research (NaPDI Center) has achieved tremendous success in establishing rigorous and definitive approaches for the design and conduct of natural product (NP)-drug interaction (NPDI) studies and advancing our understanding of pharmacokinetic NPDIs precipitated by four carefully selected high priority NPs: green tea, goldenseal, cannabis, and kratom. The success of the NaPDI Center reflects multiple inter-institutional and intra-institutional collaborations that worked effectively and efficiently with logistical, fiscal, and intellectual support provided by the Administrative Core. Roles and responsibilities of the Administrative Core are integrated into all NaPDI Center activities, at both the programmatic and project levels, ensuring that prescribed project milestones are met and within budget. Accomplishments of the Administrative Core derive from a lean leadership structure and regular, effective communication between Center investigators. As detailed in this renewal application, we propose three SPECIFIC AIMS that represent a continuation of existing Core functions with multiple innovations. AIM 1: the Administrative Core will coordinate project activities of the investigators composing the three scientific Cores (Pharmacology, Analytical, and Informatics) and their associated academic institutions, ensuring maximal scientific productivity and fiscal cohesion. The Administrative Core will partner with NCCIH to establish a Steering Committee that 1) oversees the NaPDI Center program, 2) monitors progress of the Interaction Projects and expansion of the data repository and public portal, and 3) recommends changes in scientific direction when warranted. In addition, the Administrative Core will ensure effective communication between Center investigators and the External Advisory Panel by providing regular updates of project progress and tapping the Panel’s wealth of expertise in relevant disciplines to inform strategic directions of the Center and help address specific project challenges. AIM 2: the Administrative Core will work with the Informatics Core to develop and implement innovative metrics to evaluate program success, completion of annual milestones, and impact of specific project outcomes on the scientific field and public health and safety. AIM 3: the Administrative Core will provide leadership for the broad dissemination of best practice methodologies and recommended approaches developed by the Center for the optimal conduct of human mechanistic in vitro and clinical NPDI studies. These activities will include innovative approaches to broaden outreach to national and international scientific communities. Our time-tested administrative team has developed a highly effective operational paradigm that will ensure continued productivity of the Center and translation of Center-generated data to improve public health.

行政核心的项目摘要 我们蓬勃的天然产品药物互动研究卓越中心（NAPDI中心）已取得 在建立自然设计和行为的严格和确定的方法方面取得了巨大的成功 产品（NP） - 药水相互作用（NPDI）研究并促进我们对药代动力学NPDIS的理解 由四个精心选择的高优先级NPS沉淀：绿茶，金色，大麻和kratom。 NAPDI中心的成功反映了有效的多个机构间和机构内部合作 有效，有效地利用行政核心提供的后勤，财政和智力支持。角色 行政核心的责任都集成到所有NAPDI中心活动中 程序化和项目级别，确保满足规定的项目里程碑并在预算之内。 行政核心的成就来自精益领导结构和常规，有效的 中心调查人员之间的沟通。正如本续订应用中所详述的那样，我们提出了三个特定的特定 代表具有多个创新的现有核心功能的延续的目标。目标1：行政 核心将协调组成三个科学核心的研究人员的项目活动（药理学，， 分析和信息学）及其相关的学术机构，确保最大的科学产品 和财政凝聚力。行政核心将与NCCIH合作，建立一个指导委员会，该委员会1） 监督NAPDI中心计划，2）监视交互项目的进度和扩展数据 存储库和公共门户，以及3）建议在有必要的科学方向上进行更改。另外， 行政核心将确保中心调查员与外部咨询之间有效沟通 通过定期提供项目进度的更新并利用小组相关专家的财富来面板 学科为中心的战略方向提供信息，并帮助应对特定的项目挑战。目标2： 行政核心将与信息学核心合作开发和实施创新指标以评估 计划成功，年度里程碑的完成以及特定项目成果对科学领域的影响 以及公共卫生和安全。目标3：行政核心将为广泛的传播提供领导 最佳实践方法和最佳行为中心开发的推荐方法 人类机械体外和临床NPDI研究。这些活动将包括创新的方法 扩大向国家和国际科学社区的宣传。我们经过时间考验的行政团队有 开发了一个高效的操作范式，将确保中心的持续生产力 转化中心生成的数据以改善公共卫生。