Administrative Core

行政核心

基本信息

批准号：
10471290
负责人：
MARY F PAINE
金额：
$ 41.73万
依托单位：
WASHINGTON STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10471290
关键词：
Address Budgets Cannabis Clinical Collaborations Communication Communities Data Decision Making Discipline Drug Interactions Drug Kinetics Educational workshop Ensure Evaluation Goldenseal Green tea Human In Vitro Informatics Institution International Leadership Logistics Methodology Methods Mission Mitragyna Monitor National Center for Complementary and Integrative Health Natural Product Drug Natural Products Outcome Outreach Research Pharmaceutical Preparations Pharmacology Productivity Public Health Publications Research Research Activity Research Personnel Role Running Safety Sampling Source Structure Support System Testing Thinness Time Translating Translations United States National Institutes of Health Update Visit Work clinically significant cohesion cost effective data repository design dissemination strategy improved innovation inter-institutional meetings member new technology outreach programs success symposium web site

项目摘要

PROJECT SUMMARY OF THE ADMINISTRATIVE CORE Our thriving Center of Excellence for Natural Product Drug Interaction Research (NaPDI Center) has achieved tremendous success in establishing rigorous and definitive approaches for the design and conduct of natural product (NP)-drug interaction (NPDI) studies and advancing our understanding of pharmacokinetic NPDIs precipitated by four carefully selected high priority NPs: green tea, goldenseal, cannabis, and kratom. The success of the NaPDI Center reflects multiple inter-institutional and intra-institutional collaborations that worked effectively and efficiently with logistical, fiscal, and intellectual support provided by the Administrative Core. Roles and responsibilities of the Administrative Core are integrated into all NaPDI Center activities, at both the programmatic and project levels, ensuring that prescribed project milestones are met and within budget. Accomplishments of the Administrative Core derive from a lean leadership structure and regular, effective communication between Center investigators. As detailed in this renewal application, we propose three SPECIFIC AIMS that represent a continuation of existing Core functions with multiple innovations. AIM 1: the Administrative Core will coordinate project activities of the investigators composing the three scientific Cores (Pharmacology, Analytical, and Informatics) and their associated academic institutions, ensuring maximal scientific productivity and fiscal cohesion. The Administrative Core will partner with NCCIH to establish a Steering Committee that 1) oversees the NaPDI Center program, 2) monitors progress of the Interaction Projects and expansion of the data repository and public portal, and 3) recommends changes in scientific direction when warranted. In addition, the Administrative Core will ensure effective communication between Center investigators and the External Advisory Panel by providing regular updates of project progress and tapping the Panel’s wealth of expertise in relevant disciplines to inform strategic directions of the Center and help address specific project challenges. AIM 2: the Administrative Core will work with the Informatics Core to develop and implement innovative metrics to evaluate program success, completion of annual milestones, and impact of specific project outcomes on the scientific field and public health and safety. AIM 3: the Administrative Core will provide leadership for the broad dissemination of best practice methodologies and recommended approaches developed by the Center for the optimal conduct of human mechanistic in vitro and clinical NPDI studies. These activities will include innovative approaches to broaden outreach to national and international scientific communities. Our time-tested administrative team has developed a highly effective operational paradigm that will ensure continued productivity of the Center and translation of Center-generated data to improve public health.

行政核心项目概要我们蓬勃发展的天然产物药物相互作用研究卓越中心（NaPDI 中心）已实现在建立严格和明确的自然设计和实施方法方面取得了巨大成功产品 (NP)-药物相互作用 (NPDI) 研究并增进我们对药代动力学 NPDI 的理解由四种精心挑选的高优先级 NP 促成：绿茶、金印、大麻和卡痛叶。 NaPDI 中心的成功反映了多个机构间和机构内的有效合作行政核心提供的后勤、财政和智力支持有效且高效。行政核心的职责和责任被纳入 NaPDI 中心的所有活动中，无论是计划和项目级别，确保在预算范围内达到规定的项目里程碑。行政核心的成就源自精干的领导结构和定期、有效的正如本更新申请中所详述，我们提出了三项具体要求。 AIMS 代表了现有核心功能的延续和多项创新：AIM 1：管理。核心将协调组成三个科学核心（药理学、分析学和信息学）及其相关学术机构，确保科学生产力最大化行政核心将与 NCCIH 合作建立一个指导委员会：1) 监督 NaPDI 中心计划，2) 监控交互项目的进展和数据的扩展存储库和公共门户，以及 3) 在必要时建议改变科学方向。行政核心将确保中心调查人员与外部咨询人员之间的有效沟通小组定期更新项目进展并利用小组在相关领域的丰富专业知识为中心的战略方向提供信息并帮助解决具体的项目挑战。管理核心将与信息学核心合作开发和实施创新指标来评估计划的成功、年度里程碑的完成以及具体项目成果对科学领域的影响目标 3：行政核心将为广泛传播提供领导。中心为最佳行为而开发的最佳实践方法和推荐方法这些活动将包括人类机械体外和临床 NPDI 研究的创新方法。我们久经考验的管理团队已将业务范围扩大到国内和国际科学界。制定了高效的运营模式，以确保中心的持续生产力和翻译中心生成的数据以改善公共卫生。