Prevention of LUTS: Bladder Health Clinical Center, UC San Diego Site

预防 LUTS：膀胱健康临床中心，加州大学圣地亚哥分校网站

基本信息

批准号：
10053258
负责人：
EMILY S. LUKACZ
金额：
$ 39万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-15 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10053258
关键词：
Address Adolescent Adult Affect Age Attitude Basic Science Behavioral Behavioral Research Belief Biological Biological Factors Bladder Board Certification Child Care Clinical Clinical Research Clinical Sciences Clinical Trials Clinical Trials Design Clinical and Translational Science Awards Collaborations Collection Communicable Diseases Communities Conduct Clinical Trials Data Data Analyses Data Coordinating Center Development Device or Instrument Development Discipline of obstetrics Doctor of Philosophy Doctor of Public Health Economic Burden Elements Epidemiologist Epidemiology Evidence based intervention Feasibility Studies Fellowship Female Focus Groups Fostering Foundations Funding Future General Population Genitourinary system Geography Goals Gynecologist Gynecology Habits Health Health Care Costs Health Promotion Health behavior Health education Hispanics Human Microbiome Human Resources Incidence Individual Institution International Intervention Studies Intervention Trial Investigation Knowledge Laboratories Laboratory Research Language Latina Lead Leadership Life Cycle Stages Linguistics Longitudinal Studies Longitudinal cohort Longitudinal cohort study Master&apos s Degree Measures Mediating Medicine Methods Mexican Americans Modeling Obesity Participant Pathway interactions Patient Recruitments Pediatrics Pelvis Physicians Pilot Projects Population Heterogeneity Prevalence Prevention Prevention Research Primary Health Care Protocols documentation Public Health Public Health Practice Qualitative Research Quality of life Questionnaires Reconstructive Surgical Procedures Recording of previous events Research Research Design Research Institute Research Personnel Resources Risk Factors Running Science Scientist Site Societal Factors Source Specimen Surveys Therapeutic Time Training Translational Research Translations Underrepresented Minority United States National Institutes of Health Urinary tract Urine Validation Woman Work base bilingualism clinical care clinical center clinical practice clinical research site cohort design epidemiology study ethnic diversity experience girls health disparity improved infancy innovation instrument lower urinary tract symptoms member microbiome microbiome analysis microbiome research modifiable risk multidisciplinary novel pediatrician population based programs protective factors psychosocial public health research racial diversity recruit research facility skills working group young adult young woman

项目摘要

PROJECT SUMMARY/ABSTRACT The Prevention of Lower Urinary Tract Symptoms (PLUS) Consortium was established to lay the foundation necessary to study bladder health (BH) in women and girls, including the identification of risk and protective factors for BH using a longitudinal cohort. Factors identified across the spectrum of the PLUS conceptual model, from societal to biologic, will establish the evidence base for intervention studies designed by PLUS researchers and others in the field. The objective of this application is to present the UC San Diego Clinical Research Center (CRC) as a diverse, experienced, committed, and invaluable contributor to the Consortium. We will continue to provide the unique transdisciplinary expertise necessary for the Consortium to advance the study and promotion of BH. Members of our team have extensive experience in transdisciplinary research, epidemiology, longitudinal cohort studies, prevention science, public health, health education, cross cultural research, qualitative research, primary care (Pediatrics, Obstetrics & Gynecology), clinical care of women with LUTS, and are world renown for population-based microbiome research. We boast a history of strong leadership and critical contributions to the foundational work of the Consortium, including leadership in the development and validation of instruments for BH and qualitative research on the Study of Habits, Attitudes, Realities and Experiences (SHARE) and related knowledge, attitudes and beliefs (KAB). UC San Diego is a well-established research institution, funded by the National Institutes of Health, including a sponsored Clinical & Translational Science Award which provides a full spectrum of resources and personnel for the conduct of basic science, translational, epidemiologic, behavioral, and clinical research across the full age spectrum among racially and ethnically diverse communities. In addition to the foundational work of validating the bladder health instrument (BHI) for use in a culturally diverse population, our proposal incorporates cutting edge translational research aimed at identifying a healthy urogenital microbiome. The unique strengths of our application include: a) robust contributions to the foundational work of the Consortium including two team members actively engaged in the design of the planned longitudinal cohort study; b) a history of strong recruitment and retention of ethnically diverse participants for qualitative (SHARE), quantitative clinical trials and longitudinal cohort studies; c) a conceptual model centered around the notion that BH may be mediated through societal, institutional, interpersonal, behavioral and biologic factors via the urogenital microbiome; d) a feasibility pilot study of collection and analysis of voided urine specimens from a longitudinal cohort, which will foster investigations of prevention studies that manipulate the urogenital microbiome (directly or indirectly) through changes in modifiable risk factors across the PLUS conceptual framework; and e) the development of new measures for use in linguistically and culturally diverse populations starting with an adapted and validated Hispanic (English and Spanish language) BHI and KAB questionnaire.

项目概要/摘要下尿路症状预防（PLUS）联盟成立奠定基础研究妇女和女孩的膀胱健康（BH）是必要的，包括识别风险和保护措施使用纵向队列的 BH 因素。 PLUS 概念范围内确定的因素从社会到生物的模型将为PLUS设计的干预研究建立证据基础研究人员和该领域的其他人。此应用程序的目的是展示加州大学圣地亚哥分校的临床研究中心 (CRC) 是一个多元化、经验丰富、忠诚且对联盟做出宝贵贡献的机构。我们将继续为联盟提供必要的独特的跨学科专业知识，以推进 BH的研究和推广。我们的团队成员在跨学科研究方面拥有丰富的经验，流行病学、纵向队列研究、预防科学、公共卫生、健康教育、跨文化研究、定性研究、初级保健（儿科、妇产科）、患有以下疾病的女性的临床护理 LUTS 因基于人群的微生物组研究而闻名于世。我们拥有强大的历史对联盟基础工作的领导和关键贡献，包括在 BH 工具的开发和验证以及习惯、态度研究的定性研究，现实和经验 (SHARE) 以及相关知识、态度和信念 (KAB)。加州大学圣地亚哥分校是一所由美国国立卫生研究院资助的完善的研究机构，包括赞助的临床和转化科学奖，为开展以下活动提供全方位的资源和人员全年龄段的基础科学、转化、流行病学、行为和临床研究在不同种族和族裔的社区中。除了验证的基础工作外膀胱健康仪器 (BHI) 用于文化多元化人群，我们的建议包括切割边缘转化研究旨在确定健康的泌尿生殖微生物组。我们的独特优势应用包括： a) 对联盟基础工作的大力贡献，包括两个团队成员积极参与计划的纵向队列研究的设计； b) 强大的历史招募和保留不同种族的参与者进行定性（分享）、定量临床试验和纵向队列研究； c) 围绕 BH 可能被调节这一概念的概念模型通过泌尿生殖微生物组通过社会、制度、人际、行为和生物因素； d) 一个从纵向队列中收集和分析排泄尿液样本的可行性试点研究，这将促进（直接或间接）操纵泌尿生殖微生物组的预防研究的调查通过 PLUS 概念框架中可修改风险因素的变化； e) 发展适用于语言和文化多样化人群的新措施，首先是经过调整和验证的西班牙裔（英语和西班牙语）BHI 和 KAB 问卷。