Pelvic Floor Disorders Network Clinical Site Application: The San Diego Pelvic Floor Consortium

盆底疾病网络临床站点应用：圣地亚哥盆底协会

基本信息

批准号：
10684088
负责人：
EMILY S. LUKACZ
金额：
$ 26.7万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-11 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10684088
关键词：
Academic Medical Centers Accreditation Award Basic Science Behavior Therapy Behavioral Research California Certification Clinic Clinical Clinical Pathways Clinical Research Clinical Trials Clinical Trials Network Clinical and Translational Science Awards Collaborations Communities Community Health Complication Country Creativeness Data Data Analyses Data Coordinating Center Development Diagnosis Dyspareunia Economic Burden Enrollment Environment Epidemiology Ethnic Origin Fellowship Female Fostering Funding Genitourinary system Health Maintenance Organizations Human Human Resources Image Individual Information Dissemination Institution Interdisciplinary Study Journals Knowledge Leadership Maintenance Measures Medical center Medicine Mission Modeling Operative Surgical Procedures Outcome Assessment Pain Patient Recruitments Patients Pelvic Floor Disorders Pelvic floor structure Pelvis Perioperative Pharmacogenomics Population Heterogeneity Procedures Productivity Protocols documentation Qualifying Questionnaires Randomized Reconstructive Surgical Procedures Recording of previous events Research Research Institute Research Personnel Research Project Grants Resources Sequential Multiple Assignment Randomized Trial Site Source Specialist Stress Urinary Incontinence Surgical incisions Surveys Symptoms Translational Research Underrepresented Populations United States National Institutes of Health Universities Urethra Urinary Retention Urinary tract infection Urodynamics Urologist Visit Woman Work care costs clinical research site collaborative approach community engagement comparative cost effectiveness comparative effectiveness comparative effectiveness trial cost effective treatment design epidemiology study experience functional outcomes health difference health related quality of life imaging science implementation science innovation member microbiome microbiome research multidisciplinary novel racial diversity randomized trial recruit retention rate satisfaction skills success treatment strategy trial design urinary

项目摘要

PROJECT SUMMARY The objective of this application is to highlight the San Diego Pelvic Floor Consortium (SDPFC) site qualifications to continue in the next cycle of the Pelvic Floor Disorders Network (PFDN). The success of the SDPFC in the PFDN has largely been due to our proven two-site model, which combines the strength of a tertiary academic medical center (University of California San Diego – UCSD) and a large volume community based health maintenance organization (Kaiser Permanente San Diego – Kaiser). Our site has contributed meaningfully over the past three cycles by designing and selecting cutting edge clinical trials ideally suited to this multi-centered, multi-disciplinary research network. We intend to continue to foster novel research ideas and work collaboratively with the other clinical sites and the data-coordinating center to refine studies ideally suited to clinical trials requiring large-scales and diverse populations. We boast a history of successful concept development, experience in survey development and refinement, successful implementation and recruitment for large-scale clinical trials, extensive experience in implementation of randomized trials of behavioral and surgical interventions, and maintaining high retention rates and quality data. Our proposed SMART design randomized trial of Transurethral Bulking Agent vs. Single Incision Sling (BASIS) represents an innovative and timely study of novel treatment approaches for women with stress urinary incontinence. The 15 members of the SDPFC are a diverse group of urogynecologists and urologists with the depth and breadth of scientific and clinical expertise necessary for the PFDN to continue advancing the field. Additionally, our site has an established research institution, funded by the NIH sponsored Clinical & Translational Science Award, with the full spectrum of resources and personnel available to conduct basic science, translational, epidemiologic, behavioral, and clinical research across a diverse racial/ethnic community. The SDPFC is poised to continue to recruit subjects into existing and upcoming trials at the highest levels. The intellectual contributions, leadership experience, diversity and experience in collaborative research projects makes the SDPFC ideal for this network.

项目概要此应用程序的目的是突出圣地亚哥盆底联盟 (SDPFC) 网站资格继续参加盆底疾病网络 (PFDN) 的下一个周期。 PFDN 中的 SDPFC 在很大程度上归功于我们经过验证的两站点模型，该模型结合了三级学术医疗中心（加州大学圣地亚哥分校 - UCSD）和大量的基于社区的健康维护组织（圣地亚哥凯撒医疗机构 - 凯撒）。通过理想地设计和选择尖端临床试验，在过去三个周期中做出了有意义的贡献适合这个多中心、多学科的研究网络，我们打算继续促进新颖的研究。想法并与其他临床中心和数据协调中心合作完善研究非常适合需要大规模和多样化人群的临床试验，我们拥有成功的历史。概念开发、调查开发和完善的经验、成功实施和大规模临床试验招募人员，丰富的随机试验实施经验行为和手术干预，并保持高保留率和高质量数据。经尿道膨胀剂与单切口吊带 (BASIS) 的 SMART 设计随机试验代表了一项对女性压力性尿失禁的新治疗方法进行创新和及时的研究 The 15。 SDPFC 的成员是由泌尿妇科医师和泌尿科医师组成的多元化群体，其研究的深度和广度 PFDN 继续推进该领域所需的科学和临床专业知识。拥有一个成熟的研究机构，由 NIH 赞助的临床与转化科学奖资助，拥有可用于开展基础科学、转化、 SDPFC 致力于跨不同种族/民族社区的流行病学、行为和临床研究。准备继续招募受试者参加现有和即将进行的最高级别的试验。贡献、领导经验、多样性和合作研究项目的经验使 SDPFC 非常适合该网络。