Case Western Reserve University StrokeNet Regional Coordinating Center

凯斯西储大学 StrokeNet 区域协调中心

基本信息

批准号：
10018672
负责人：
SOPHIA SUNDARARAJAN
金额：
$ 31.3万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-15 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10018672
关键词：
Academic Medical Centers Accident and Emergency department Acute Adult Air Award Biotechnology Caring Child Clinic Clinical Clinical Sciences Clinical Trials Clinical Trials Design Clinical Trials Unit Collaborations Communities Country County Hospitals Critical Care Data Engineering Enrollment Ensure Ethnic Origin Fostering Funding Grant Great Lakes Region Healthcare Systems Hospitals Image Individual International Intervention Lead Leadership Medical center Mentors Mentorship Michigan Monitor Neurology Nurses Participant Physicians Population Positioning Attribute Prevention Race Recording of previous events Recovery Rehabilitation therapy Research Research Personnel Resources Role Route Running Rural Scientist Site Stroke Structure System Training Translational Research Transportation United States Department of Veterans Affairs United States National Institutes of Health Universities University Hospitals West Virginia Work acute care acute stroke functional electrical stimulation neurosurgery novel therapeutics organizational structure patient population programs screening sex stroke clinical trials stroke patient stroke trials study population

项目摘要

Cleveland is an urban community with several healthcare systems, internationally renowned researchers and a rich history of cooperation with respect to stroke care. University Hospitals of Cleveland (University Hospitals), The Cleveland Clinic, MetroHealth and the Louis Stokes Cleveland VA Medical Center (Cleveland VA) are affliated with Case Western Reserve University (CWRU) and collaborate in a Clinical Translational Science Collaborative (CTSC- funded by a CTSA) to enhance training, research, and discovery in Cleveland. In 2013 we were awarded a Regional Coordinating Center (RCC) as part of NIH StrokeNet. This application is to to renew that grant. We have expanded our RCC adding sites in Toledo (Mercy St Vincent Medical Center or Mercy St Vincent), Columbus (OhioHealth), Grand Rapids, Michigan (SpectrumHealth) and Morgantown, WV (West Virginial University (WVU). The inclusion of one county hospital with a large emergency department, VA hospital, and two urban academic medical centers, one academic medical center in a rural state ensures a diverse patient and study population. Our RCC has excellent participation and quality metrics on StrokeNet studies, including the highest enrollment in StrokeNet study in the Great Lakes Region. We have a diverse research community, with clinical researchers, basic scientists, engineers and biotech companies, to collaborate with and bring new projects to the network. We have large hospitals systems, including 3 hospitals ranked in the top 50 Neurology and Neurosurgery programs in the country, 6 Comprehensive Stroke Centers and a seventh site that will be reviewed for Comprehensive designation in October 2017. We have state of the art transportation resources including critical care air transport with physicians and nurse practicioners on board and 2 hospital systems with mobile stroke units that administer thrombolytics in the field or en route to the hospital. We have special expertise in penumbral imaging, acute endovascular therapy and rehabilitation and functional electrical stimulation. We propose a multi-teired leadership. Dr Sophia Sundararajan and Dr. Ken Uchino will lead the RCC as PIs, and representatives from each of the eight hospitals will serve on the Executive committee with the PIs, as will a Project Manager and Training Director. The Executive Committee includes senior and more junior investigators and will oversee and run all aspects of the RCC, but also provide mentorship for more junior investigators. Our leadership succession plan has already successfully mentored Drs Sundararajan and Uchino who will assume the Co-PI roles of this application. With the expertise and resources detailed in this application, the Case Western Reserve University RCC will be well positioned to enhance the structure and organization of our RCC and further accelerate participation in clinical trials for stroke acute intervention, prevention and rehabilitation in both adults and children.

克利夫兰是一个城市社区，拥有多个医疗保健系统、国际知名研究人员以及在中风护理方面丰富的合作历史。克利夫兰大学医院（大学医院）、克利夫兰诊所、MetroHealth 和路易斯·斯托克斯克利夫兰退伍军人医疗中心（克利夫兰弗吉尼亚州）隶属于凯斯西储大学 (CWRU)，并在临床领域进行合作转化科学合作组织（CTSC-由 CTSA 资助）旨在加强培训、研究和克利夫兰的发现。 2013 年，我们被授予区域协调中心 (RCC)，作为 NIH 的一部分中风网。本申请旨在更新该补助金。我们扩大了在托莱多的 RCC 添加站点（慈善圣文森特医疗中心或慈善圣文森特），哥伦布（俄亥俄健康局），大急流城，密歇根州（SpectrumHealth）和西弗吉尼亚州摩根敦（西弗吉尼亚大学 (WVU)）。纳入一个县拥有大型急诊科的医院、VA 医院和两个城市学术医疗中心，其中一个农村州的学术医疗中心确保多样化的患者和研究人群。我们的 RCC 在 StrokeNet 研究中拥有出色的参与度和质量指标，包括最高的大湖区 StrokeNet 研究的注册人数。我们拥有多元化的研究社区，临床研究人员、基础科学家、工程师和生物技术公司合作并带来新的成果项目到网络。我们拥有大型医院系统，其中3家医院排名前50 该国的神经病学和神经外科项目、6 个综合中风中心和第七个中心将于 2017 年 10 月接受综合指定审查。我们拥有最先进的技术运输资源，包括机上有医生和执业护士的重症监护航空运输以及 2 个配备移动中风病房的医院系统，可在现场或前往救治中心的途中进行溶栓治疗医院。我们在半影成像、急性血管内治疗和康复方面拥有特殊的专业知识和功能性电刺激。我们提出多级领导。索菲亚·桑达拉拉詹 (Sophia Sundararajan) 博士和 Ken Uchino 将作为 PI 领导 RCC，八家医院的代表将在该委员会任职执行委员会与 PI 以及项目经理和培训总监一起。执行官委员会包括高级和初级研究人员，将监督和管理 RCC 的各个方面，还为更多初级研究人员提供指导。我们的领导继任计划已经成功指导了 Sundararajan 博士和 Uchino 博士，他们将担任该应用程序的 Co-PI 角色。凭借本申请中详细介绍的专业知识和资源，凯斯西储大学 RCC 将处于有利地位，可以加强我们 RCC 的结构和组织并进一步加速参与成人和儿童中风急性干预、预防和康复的临床试验。