INVESTIGATING AGE-RELATED DIFFERENCES IN COGNITIVE AND NEURAL REPRESENTATIONS IN ASSOCIATIVE MEMORY

研究联想记忆中认知和神经表征与年龄相关的差异

基本信息

批准号：
10047137
负责人：
Amy A Overman
金额：
$ 41.4万
依托单位：
ELON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-06-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10047137
关键词：
Address Affect Age Aging Alzheimer&apos s Disease Anterior Auditory Behavioral Behavioral Model Binding Brain Cognitive Computer Models Dementia Disease Elderly Elements Episodic memory Experimental Designs Failure Functional Magnetic Resonance Imaging Goals Grant Health Hippocampus (Brain)Human Impairment Individual Intervention Investigation Knowledge Life Link Medial Medicine Memory Memory impairment Methods Minor Modality Modeling Outcome Performance Population Predisposition Proactive Inhibition Public Health Quality of life Research Retrieval Safety Semantics Specificity Stimulus System Techniques Temporal Lobe Testing Time Update Visual Work age difference age related base cognitive function emotional distress experience experimental study healthy aging improved innovation insight method development neural patterning neuroimaging novel relating to nervous system theories therapy development young adult

项目摘要

Older adult memory is vulnerable to an associative deficit – a decline in the ability to link together multiple pieces of information. This has implications for many aspects of cognitive functioning in everyday life, such as remembering to take medicine at a certain time of day. However, not enough is known about the neural bases of the associative deficit. For example, how does the associative deficit fit into broader theories of the functional organization of memory networks in the human brain, and how is the associative deficit linked to age-related changes in neural representations of information? The long-term goal of the proposed research is to gain understanding of associative memory mechanisms in aging so that beneficial intervention strategies for memory can be developed for use with older adults. The objective of the current research is to test whether specific age- related differences in associative memory can be accounted for by differences in neural specificity and functional connectivity in posterior-medial and anterior-temporal cortico-hippocampal networks. The overarching hypothesis is that the associative deficit depends on the degree to which neural specificity and functional connectivity each contribute to a task. The rationale for the proposed research is that investigating age-related differences in neural representations and functional connectivity in associative memory will lead to a more robust theory of the associative deficit, and will enable the development of methods for presenting information to older adults in ways that reduce age differences in associative memory. Innovative fMRI experiments are proposed that will: 1) Examine how encoding of new associations is affected by age differences in reactivation and processing of prior associations and in the dynamics of cortico-hippocampal networks; and 2) Investigate how dedifferentiation in perceptual regions contributes to age differences in the encoding and retrieval of associations within cortico-hippocampal networks for memory. The approach is innovative because the planned experiments will combine novel experimental designs with advanced fMRI analysis methods to bridge the gap between cognitive theories of the associative deficit and underlying neural differences between young and older adults. The proposed research is significant because results of the studies will generate new insights in scientific understanding of the neural bases of the associative deficit. This work represents a critical step toward a unified explanation of associative memory deficits in aging. It will advance the field of aging and memory as well as enable the development of interventions, such as more effective means of presenting information, that may improve information representations in associative memory, thereby improving health and quality of life.

老年人的记忆很容易受到联想防御的影响 - 将多个部分连接在一起的能力下降信息。这对每日生活的认知功能的许多方面都有影响，例如记住在一天中的某个时间服药。但是，关于神经底座还不够关联赤字。例如，关联赤字如何拟合到功能的更广泛的理论人脑中的记忆网络组织，联想防御与与年龄有关信息神经表示的变化？拟议研究的长期目标是获得了解衰老中的关联记忆机制，以便对记忆的有益干预策略可以开发用于老年人。当前研究的目的是测试特定年龄是否关联记忆的相关差异可以通过神经特异性和功能的差异来解释后内侧和前颞皮层 - 海马网络中的连通性。总体假设是关联赤字取决于神经特异性和功能的程度连通性每个都有助于任务。拟议的研究的理由是研究与年龄有关神经表示的差异和联想记忆中的功能连接性将导致更强大协会辩护的理论，并将能够开发向较老的信息提供信息的方法成年人以减少联想记忆年龄差异的方式。提出了创新的FMRI实验这将：1）检查新关联的编码如何受重新激活年龄差异和处理先前关联和皮质 - 海马网络的动力学； 2）调查如何感知区域的去分化有助于编码和检索的年龄差异在Cortico-Hampocampal网络中以用于内存。这种方法是创新的，因为计划的实验将新颖的实验设计与高级fMRI分析方法相结合，以弥合相关赤字的认知理论以及年轻人和老年人之间的基本神经差异。拟议的研究很重要，因为研究的结果将产生科学的新见解了解协会防御的神经基础。这项工作代表着迈向统一的关键一步衰老中关联记忆防御的说明。它将推进衰老和记忆的领域以及使干预措施的发展，例如提出信息的更有效方法，可能改善关联记忆中的信息表示，从而改善健康和生活质量。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A Positive Generation Effect on Memory for Auditory Context.

DOI：
10.3758/s13423-016-1169-4
发表时间：
2017-06
期刊：
Psychonomic bulletin & review
影响因子：
3.5
作者：
Overman AA;Richard AG;Stephens JDW
通讯作者：
Stephens JDW

Strategies for Group-Level Mentoring of Undergraduates: Creating a Laboratory Environment That Supports Publications and Funding.

本科生团体指导策略：创建支持出版物和资助的实验室环境。

DOI：
10.3389/fpsyg.2019.00323
发表时间：
2019
期刊：
Frontiers in psychology
影响因子：
3.8
作者：
Overman,AmyA
通讯作者：
Overman,AmyA

Understanding associative false memories in aging using multivariate analyses.

DOI：
10.1080/13825585.2022.2037500
发表时间：
2022-05
期刊：
AGING NEUROPSYCHOLOGY AND COGNITION
影响因子：
1.9
作者：
Dennis, Nancy A.;Overman, Amy A.;Carpenter, Catherine M.;Gerver, Courtney R.
通讯作者：
Gerver, Courtney R.

Neural distinctiveness and reinstatement of hippocampal representations support unitization for associations.

DOI：
10.1016/j.brainres.2022.148143
发表时间：
2023-01-01
期刊：
Brain research
影响因子：
2.9
作者：
通讯作者：

Neural distinctiveness and discriminability underlying unitization and associative memory in aging.

DOI：
10.1016/j.nbas.2023.100097
发表时间：
2023
期刊：
AGING BRAIN
影响因子：
0
作者：
Steinkrauss, A. C.;Carpenter, C. M.;Tarkenton, M. K.;Overman, A. A.;Dennis, N. A.
通讯作者：
Dennis, N. A.