Social Circumstances and Epigenomics Promoting Health in Three Countries

社会环境和表观基因组学促进三个国家的健康

• 批准号: 10045912
• 负责人: EILEEN M CRIMMINS
• 金额: $ 62.96万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10045912
• 关键词: Address; Adult; Affect; Age; Aging; Base Sequence; Behavioral; Biological; Biological Assay; Buffers; Characteristics; Childhood; Chronic Disease; Chronic stress; Collaborations; Collection; Country; DNA Methylation; Data; Data Set; Development; Diabetes Mellitus; Disease; Economics; Education; Educational Background; Elderly; Epigenetic Process; Ethnic Origin; Event; Exposure to; Family health status; Funding; Funding Agency; Genome; Grant; Grant Review; Health; Health Policy; Health Promotion; Health and Retirement Study; Health behavior; Heart Diseases; Income; Ireland; Life; Life Cycle Stages; Link; Longitudinal Studies; Longitudinal cohort study; Measures; Methylation; Minority Groups; Modification; Molecular; Northern Ireland; Outcome; Pattern; Physical Function; Physiological; Policies; Population; Poverty; Premature Mortality; Process; Psychological Factors; Race; Recording of previous events; Research; Resources; Risk; Role; Sampling; Skin; Social isolation; Social support; Stress; Stroke; Surveys; Trauma; United States; United States National Institutes of Health; adverse childhood events; base; cognitive function; comparative; contextual factors; data harmonization; design; disability; early onset; epigenetic marker; epigenomics; experience; frailty; member; mortality; population based; potential biomarker; psychologic; research and development; resilience; response; safety net; social; social determinants; social disadvantage; social factors; socioeconomics

This project proposes an integrated set of aims and analyses of existing social and epigenetic data from three national studies of aging in the family of Health and Retirement studies (the US Health and Retirement Study (HRS), the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA), and the Irish Longitudinal Study of Aging (TILDA)); assays of existing samples to produce longitudinal epigenetic data for the three countries are also proposed. Comparative analyses based on these data will address central questions about how life circumstances in both childhood and adulthood affect epigenetic change and how different historical and life-course exposures in these countries may result in differential patterns of associations. The project will also examine how epigenetic changes in turn are associated with health after age 50. The proposal is submitted in response to the US-Ireland Research and Development Partnership, a unique research initiative involving funding agencies from the United States (US), the Republic of Ireland (RofI), and Northern Ireland (NI). Proposals are submitted to each of the three countries with funding requested for each country's participation from their respective grant agency (e.g., US NIH); grant review is done only by NIH for all three projects based on this proposal. The project will examine the links between lifetime social, economic, psychological, environmental and behavioral circumstances, and epigenetic markers related to aging and health, and subsequent health. Epigenetic modification is one of the “hallmarks” of aging, i.e. an underlying physiological change that can speedup or delay aging-related health outcomes. Faster aging is characteristic of people in adverse social circumstances and epigenetic change, particularly DNA methylation (DNAm), appears to be especially influenced by adverse social circumstances, both at early ages and at later ages. This project will be unique in evaluating how a variety of social circumstances, i.e. low levels of education and income, minority group membership, adverse childhood experiences, adult traumas, risky health behaviors, psychological states, and chronic stress, are associated with epigenetic markers in three different countries, with somewhat different historical, social and behavioral characteristics which are operating in different health policy regimes – allowing for both replication where effects are hypothesized to be similar and differentiation where they are hypothesized to differ (e.g., where risk characteristics are differentially patterned by SES). The applicants are uniquely placed with their resources to explore how socioeconomic experiences across the life course alter epigenetic profiles to influence health outcomes such as biological dysregulation, frailty, disability, chronic disease, and premature mortality. The three data sets have been harmonized for information collection from the beginning of the studies and were designed to encourage comparative analysis. They have been harmonized in the survey information and the development of the epigenetic data in the three countries. Each country has strong independent research teams who bring unique expertise and resources and a history of collaboration to this collaborative proposal.

该项目提出了一组综合的目的和分析三个现有的社会和表观遗传数据 全国性卫生与退休研究家族衰老研究（美国卫生与退休研究） （HRS），北爱尔兰纵向研究（尼古拉）和爱尔兰纵向研究 衰老研究（Tilda））；现有样品的测定以生成三个样品的纵向表观遗传学数据 还提出了国家。基于这些数据的比较分析将解决有关的中心问题 童年和成年期的生活环境如何影响表观遗传变化以及历史和不同 这些国家的生活道路暴露可能会导致关联的不同模式。该项目也将 检查表观遗传变化依次与50岁以后的健康有关。该提议提交 对美国 - 爱尔兰研发伙伴关系的回应，这是一项独特的研究计划 来自美国（美国），爱尔兰共和国（ROFI）和北爱尔兰（NI）的资助机构。 提案提交给三个国家 /地区的每个国家 /地区的资金 来自他们各自的赠款机构（例如，美国国民党）；赠款审查仅由NIH完成所有三个项目 在此提案中。该项目将研究终生，经济，心理学， 环境和行为环境以及与衰老和健康有关的表观遗传标记，以及 随后的健康。表观遗传修饰是衰老的“标志”之一，即潜在的生理 更改可以加速或延迟与衰老有关的健康结果。更快的衰老是人们的特征 不利的社会环境和表观遗传变化，尤其是DNA甲基化（DNAM），似乎是 尤其受到不利社会环境的影响，无论是在早期还是后来的年龄。这个项目将是 在评估各种社会环境（即低水平的教育和收入，少数人）中的独特之处 团体成员资格，不良童年经历，成人创伤，风险的健康行为，心理状态， 和慢性压力与三个不同国家的表观遗传标记有关，有些不同 在不同的健康政策制度中运行的历史，社会和行为特征 - 允许 对于两个复制，假设效果是相似的，并且分化了。 到不同的（例如，风险特征是由SES差异化的）。申请人独特地放置 借助他们的资源来探讨整个生活课程的社会经济经历如何改变表观遗传概况 影响健康结果，例如生物失调，脆弱，残疾，慢性病和早产 死亡。这三个数据集从研究开始就已经进行了协调以进行信息收集 并旨在鼓励比较分析。他们在调查信息中已经统一了 以及三个国家的表观遗传数据的发展。每个国家都有强大的独立研究 为该协作提案带来独特的专业知识和资源以及合作历史的团队。