Programming Resource Core

编程资源核心

• 批准号: 10013205
• 负责人: Jonathan B Demb
• 金额: $ 11.16万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10013205
• 关键词: Anatomy; Back; Behavioral; Cells; Complement; Computer Hardware; Computer Interface; Computer software; Core Grant; Custom; Data; Data Analyses; Devices; Electronics; Equipment; Glutamates; Goals; Image; In Vitro; Maintenance; Microscope; Mus; Neurobiology; Neurons; Physiological; Population; Preparation; Primates; Process; Research; Research Methodology; Research Personnel; Resources; Services; Structure; Techniques; Technology; Vision; Vision research; Visual; Visual system structure; design; experimental study; fly; in vivo; innovation; novel; relating to nervous system; sensor; success; two-photon; vision science

Programming Core Module Abstract The Programming Core Module's primary goal is to facilitate the wide range of computational programming required for visual system experiments and analysis at Yale. Vision research methodology has become increasingly sophisticated, requiring new computational strategies to support advanced technologies. For example, multiple vision researchers at Yale now routinely use genetically-encoded fluorescent sensors of neural activity (e.g., Ca2+ influx: GCaMP6; glutamate release: iGluSnFR) combined with two-photon imaging to study the structure and function of visual neurons. These experiments span a range of scales – from dendritic processes to cell populations – and encompass both in vitro and in vivo preparations. These techniques complement state-of-the-art behavioral experiments – performed in flies, mice and primates – that identify novel visual computations and their neurobiological correlates. These cutting-edge studies have a high potential for innovation and impact, but their success depends on custom software and electronic components for experiment implementation and data analysis. The Programmer will support the design and implementation of custom software for collecting and analyzing anatomical, physiological and behavioral data in multiple species (fly, mouse, primate) and will facilitate efficient strategies for data maintenance and back up. Additional duties include custom design of electronic circuits and device drivers; troubleshooting problems with computer hardware and electronics; and facilitating computer interface with specialized scientific equipment (e.g., cameras, microscopes).

编程核心模块摘要 编程核心模块的主要目标是促进广泛的计算编程 在耶鲁大学进行视觉系统实验和分析所需。视觉研究方法已经成为 越来越复杂，需要新的计算策略来支持高级技术。为了 例如，耶鲁大学的多个视力研究人员现在通常使用遗传编码的荧光传感器 神经活动（例如Ca2+影响：GCAMP6；谷氨酸释放：IglusnFR）与两光子成像结合 研究视觉神经元的结构和功能。这些实验跨越了一系列尺度 - 从树突状 到细胞群体的过程 - 并包括体外和体内制剂。这些技术 补充最先进的行为实验 - 在苍蝇，小鼠和主要的主要中进行 - 识别 新型的视觉计算及其神经生物学相关。这些尖端研究很高 创新和影响的潜力，但它们的成功取决于自定义软件和电子组件 用于实验和数据分析。程序员将支持设计和 实施自定义软件，用于收集和分析解剖，物理和行为数据 在多种物种（飞鼠，鼠标，灵长类动物）中，将促进有效的数据维护策略和返回 向上。其他职责包括电子电路和设备驱动程序的定制设计；故障排除问题 使用计算机硬件和电子设备；并通过专门的科学支持计算机界面 设备（例如，相机，显微镜）。