Internalizing Behaviors and Neuroimaging Outcomes: Impact of PBDE and PFC Exposures

内化行为和神经影像结果：PBDE 和 PFC 暴露的影响

• 批准号: 10015279
• 负责人: Kim M Cecil
• 金额: $ 54.6万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10015279
• 关键词: 12 year old; Address; Affect; Age; Anatomy; Anxiety; Behavior; Birth; Brain; Chemical Exposure; Chemicals; Child; Child Development; Childhood; Cohort Studies; Communities; Coupled; Data; Development; Enrollment; Environment; Environmental Pollution; Exposure to; Fetal Development; Flame Retardants; Health; Human; Imaging Techniques; Impairment; Injury; Knowledge; Lead; Link; Longitudinal Studies; Longterm Follow-up; Magnetic Resonance Imaging; Measures; Mediating; Mental Depression; Methodology; Microscopic; Nature; Newborn Infant; Nursery Schools; Outcome; Outcome Measure; Phase; Plasticizers; Population; Pregnancy; Prospective Studies; Reporting; Role; Sampling; School-Age Population; Serum; Specimen; Statistical Models; Structure; Symptoms; Time; Tobacco; Toxic Environmental Substances; Visit; Woman; Work; anxiety symptoms; cohort; critical period; exposed human population; follow-up; improved; innovation; longitudinal design; neural network; neurobehavioral; neurochemistry; neurodevelopment; neuroimaging; novel; offspring; pollutant; polybrominated diphenyl ether; postnatal; preadolescence; prenatal; prenatal exposure; social; surfactant; tool; white matter

Project Summary/Abstract Human exposure to environmental contaminants is ubiquitous, and there is growing concern that exposure to some may be linked with the rise in neurobehavioral problems in children. Given the lack of conclusive evidence for many environmental toxicants, there is a critical need for well-designed longitudinal studies of prenatal and postnatal exposure with long-term follow-up to address focused questions about the impact of these chemicals, especially on neurobehavioral endpoints. We will study two chemical classes to which nearly all of the US population are exposed, polybrominated diphenyl ethers (PBDEs) and perfluorinated chemicals (PFCs), that have been used as flame retardants and surfactants, respectively. Among an established cohort of typically developing pre-adolescent children within the Health Outcomes and Measures of the Environment (HOME) Study, we will determine associations between prenatal and childhood exposure to these persistent pollutants and internalizing behaviors including anxiety, depression and social impairment. We will also obtain neuroimaging outcomes to examine associations with exposure. The HOME Study enrolled women during pregnancy and has thus far followed offspring until age 8y. We will extend follow-up to include a study visit at 11-12y to study associations in the pre-adolescent period. Prenatal exposures were measured using maternal pregnancy and newborn specimens with multiple childhood samples currently being analyzed. Over 97% of participating women had detectable levels of PBDEs and PFCs during pregnancy; comparable with nationally reported levels. We hypothesize that exposures to these chemicals subtly alter the brain to produce neurobehavioral deficits that will be evident in increased internalizing symptoms and adverse changes in anatomical structure, neurochemistry, organization of white matter tracts, and connectivity of neural networks. Aim 1: To determine the impact of prenatal and childhood exposures to PBDEs and PFCs on internalizing symptoms in a longitudinal birth cohort of 11-12 year old children. Aim 2: To determine the impact of prenatal and childhood exposures to PBDEs on brain structure, organization, and function in a longitudinal birth cohort of 11-12 year old children. Exploratory aim (EA): To determine the impact of prenatal and childhood exposures to PFCs on brain structure, organization, and function in a longitudinal birth cohort of 11-12 year old children. Aim 3: To determine the potential mediational impact of brain structure, organization and function in the relationship between prenatal and childhood exposures to PBDEs and internalizing symptoms in a longitudinal birth cohort of 11-12 year old children. Aim 4: To identify appropriate statistical methodologies to determine the association of single and multiple PBDE and PFC exposures with neurodevelopment across multiple developmental stages.

项目概要/摘要 人类接触环境污染物的现象无处不在，人们越来越担心接触环境污染物 有些可能与儿童神经行为问题的增加有关。鉴于缺乏确凿的证据 由于许多环境毒物的证据，迫切需要精心设计的纵向研究 产前和产后接触并进行长期随访，以解决有关影响的重点问题 这些化学物质，尤其是神经行为终点。我们将学习两门化学课程，几乎 所有美国人都接触多溴二苯醚 (PBDE) 和全氟化学品 （PFC），分别用作阻燃剂和表面活性剂。在已建立的队列中 健康成果和环境措施中典型发育的青春期前儿童的比例 (HOME) 研究中，我们将确定产前和儿童时期接触这些持续存在的物质之间的关联 污染物和内化行为，包括焦虑、抑郁和社交障碍。我们还将获得 神经影像学结果检查与暴露的关系。 HOME 研究招募了女性 怀孕并迄今为止对后代进行跟踪直至 8 岁。我们将扩大后续行动，包括在以下地点进行考察访问： 11-12岁学习青春期前的关联。使用母亲测量产前暴露 目前正在分析怀孕和新生儿样本以及多个儿童样本。超过97% 参与的妇女在怀孕期间可检测到多溴联苯醚和全氟化碳的含量；与国内相当 报告的水平。我们假设接触这些化学物质会微妙地改变大脑产生 神经行为缺陷，表现为内化症状的增加和不良变化 解剖结构、神经化学、白质束的组织以及神经网络的连接。 目标 1：确定产前和儿童时期接触 PBDE 和 PFC 对内化的影响 11-12 岁儿童纵向出生队列中的症状。 目标 2：确定产前和儿童时期接触多溴联苯醚对大脑结构的影响， 11-12 岁儿童纵向出生队列的组织和功能。 探索性目标 (EA)：确定产前和儿童时期接触 PFC 对大脑的影响 11-12 岁儿童纵向出生队列的结构、组织和功能。 目标 3：确定大脑结构、组织和功能的潜在中介影响 产前和儿童时期多溴联苯醚暴露与内化症状之间的纵向关系 11-12岁儿童的出生队列。 目标 4：确定适当的统计方法来确定单个和多个的关联 PBDE 和 PFC 暴露与跨多个发育阶段的神经发育有关。