Internalizing Behaviors and Neuroimaging Outcomes: Impact of PBDE and PFC Exposures

内化行为和神经影像结果：PBDE 和 PFC 暴露的影响

• 批准号: 10015279
• 负责人: Kim M Cecil
• 金额: $ 54.6万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10015279
• 关键词: 12 year old; Address; Affect; Age; Anatomy; Anxiety; Behavior; Birth; Brain; Chemical Exposure; Chemicals; Child; Child Development; Childhood; Cohort Studies; Communities; Coupled; Data; Development; Enrollment; Environment; Environmental Pollution; Exposure to; Fetal Development; Flame Retardants; Health; Human; Imaging Techniques; Impairment; Injury; Knowledge; Lead; Link; Longitudinal Studies; Longterm Follow-up; Magnetic Resonance Imaging; Measures; Mediating; Mental Depression; Methodology; Microscopic; Nature; Newborn Infant; Nursery Schools; Outcome; Outcome Measure; Phase; Plasticizers; Population; Pregnancy; Prospective Studies; Reporting; Role; Sampling; School-Age Population; Serum; Specimen; Statistical Models; Structure; Symptoms; Time; Tobacco; Toxic Environmental Substances; Visit; Woman; Work; anxiety symptoms; cohort; critical period; exposed human population; follow-up; improved; innovation; longitudinal design; neural network; neurobehavioral; neurochemistry; neurodevelopment; neuroimaging; novel; offspring; pollutant; polybrominated diphenyl ether; postnatal; preadolescence; prenatal; prenatal exposure; social; surfactant; tool; white matter

Project Summary/Abstract Human exposure to environmental contaminants is ubiquitous, and there is growing concern that exposure to some may be linked with the rise in neurobehavioral problems in children. Given the lack of conclusive evidence for many environmental toxicants, there is a critical need for well-designed longitudinal studies of prenatal and postnatal exposure with long-term follow-up to address focused questions about the impact of these chemicals, especially on neurobehavioral endpoints. We will study two chemical classes to which nearly all of the US population are exposed, polybrominated diphenyl ethers (PBDEs) and perfluorinated chemicals (PFCs), that have been used as flame retardants and surfactants, respectively. Among an established cohort of typically developing pre-adolescent children within the Health Outcomes and Measures of the Environment (HOME) Study, we will determine associations between prenatal and childhood exposure to these persistent pollutants and internalizing behaviors including anxiety, depression and social impairment. We will also obtain neuroimaging outcomes to examine associations with exposure. The HOME Study enrolled women during pregnancy and has thus far followed offspring until age 8y. We will extend follow-up to include a study visit at 11-12y to study associations in the pre-adolescent period. Prenatal exposures were measured using maternal pregnancy and newborn specimens with multiple childhood samples currently being analyzed. Over 97% of participating women had detectable levels of PBDEs and PFCs during pregnancy; comparable with nationally reported levels. We hypothesize that exposures to these chemicals subtly alter the brain to produce neurobehavioral deficits that will be evident in increased internalizing symptoms and adverse changes in anatomical structure, neurochemistry, organization of white matter tracts, and connectivity of neural networks. Aim 1: To determine the impact of prenatal and childhood exposures to PBDEs and PFCs on internalizing symptoms in a longitudinal birth cohort of 11-12 year old children. Aim 2: To determine the impact of prenatal and childhood exposures to PBDEs on brain structure, organization, and function in a longitudinal birth cohort of 11-12 year old children. Exploratory aim (EA): To determine the impact of prenatal and childhood exposures to PFCs on brain structure, organization, and function in a longitudinal birth cohort of 11-12 year old children. Aim 3: To determine the potential mediational impact of brain structure, organization and function in the relationship between prenatal and childhood exposures to PBDEs and internalizing symptoms in a longitudinal birth cohort of 11-12 year old children. Aim 4: To identify appropriate statistical methodologies to determine the association of single and multiple PBDE and PFC exposures with neurodevelopment across multiple developmental stages.

项目摘要/摘要 人类暴露于环境污染物的无处不在，并且越来越担心 一些可能与儿童神经行为问题的增加有关。鉴于缺乏结论性 许多环境有毒物质的证据，迫切需要精心设计的纵向研究 产前和产后暴露以及长期随访，以解决有关有关影响的重点问题 这些化学物质，尤其是在神经行为终点上。我们将研究两个化学班，几乎 美国所有人口均暴露，多溴二苯基醚（PBDES）和全氟化学物质 （PFC），分别用作阻燃剂和表面活性剂。在一个已建立的队列中 在健康成果和环境措施中典型发展青春期前儿童 （家庭研究），我们将确定产前与儿童期与这些持续的相关性 污染物和内在行为，包括焦虑，抑郁和社会障碍。我们还将获得 神经影像结果检查与暴露的关联。家庭学习在 怀孕，到目前为止，后代一直到8岁。我们将扩展后续行动，包括在 11-12y在青春期前研究协会。使用母体测量产前暴露 目前正在分析具有多个童年样本的怀孕和新生儿标本。超过97％ 参与的妇女在怀孕期间具有可检测到的PBDES和PFC水平；在全国范围内可比 报告的水平。我们假设暴露于这些化学物质的暴露巧妙地改变了大脑以产生 神经行为缺陷将在增加内在症状和不利变化中显而易见 解剖结构，神经化学，白质区的组织以及神经网络的连通性。 目的1：确定产前和儿童时期对PBDE和PFC的影响对内在化的影响 11-12岁儿童的纵向出生队列中的症状。 目标2：确定产前和儿童期暴露于PBDE对大脑结构的影响， 组织，并在11-12岁的纵向出生队列中发挥作用。 探索目的（EA）：确定产前和儿童期暴露于PFC对大脑的影响 结构，组织和功能在11-12岁的纵向出生队列中。 目标3：确定大脑结构，组织和功能的潜在中介作用 产前与儿童期暴露于PBDES和纵向内部症状之间的关系 11至12岁的孩子的出生队列。 目标4：确定适当的统计方法来确定单个和多个的关联 PBDE和PFC暴露于多个发育阶段的神经发育。