Longitudinal Impact of Air Pollution on Mental Health and Neuroimaging Outcomes during Adolescence in the Cincinnati Combined Childhood Cohorts (C4)

空气污染对辛辛那提联合儿童队列 (C4) 青春期心理健康和神经影像结果的纵向影响

• 批准号: 10543450
• 负责人: Kim M Cecil
• 金额: $ 108.49万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-03 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10543450
• 关键词: 12 year old; 18 year old; Acute; Address; Adolescence; Adolescent; Adult; Affect; Age; Air Pollutants; Air Pollution; American; Aminobutyric Acids; Anatomy; Anxiety; Attention deficit hyperactivity disorder; Biological; Birth; Brain; Cause of Death; Child; Childhood; Conceptions; Data; Development; Diameter; Diesel Exhaust; Disease; Early identification; Early treatment; Emergency department visit; Environment; Exposure to; Functional Magnetic Resonance Imaging; Future; Genetic; Genetic Predisposition to Disease; Glutathione; Health; Hormonal; Hypersensitivity; Incidence; Intervention; Justice; Life; Link; Longitudinal cohort; Measures; Mediating; Mental Depression; Mental Health; Mental disorders; Metabolism; Modeling; Motor Skills; Neuropsychology; Ohio; Outcome; Oxidative Stress Induction; Particulate Matter; Pathway interactions; Policies; Population; Prevalence; Prevention; Preventive; Primary Prevention; Prospective cohort; Recurrence; Research; Risk; Risk Factors; Role; School Drop-Outs; Schools; Structure; Student Dropouts; Suicide attempt; System; Teenagers; Testing; Time; Toxicology; Unemployment; Well in self; age group; autism spectrum disorder; brain volume; child depression; cognitive ability; cohort; critical period; diagnostic criteria; disorder risk; early adolescence; epidemiology study; experience; externalizing behavior; fine particles; follow-up; gamma-Aminobutyric Acid; hospitalization rates; meter; modifiable risk; neuroimaging; neuroinflammation; neurotoxic; novel; pollutant; prenatal; prevent; prospective; public health intervention; screening; social; social determinants; study population; substance use; suicidal risk; traffic-related air pollution; ultrafine particle; young adult

PROJECT SUMMARY / ABSTRACT More than one in five adolescents will experience a mental health disorder, including depression and anxiety, and the prevalence of these conditions is increasing. Among adolescents, depression and anxiety are linked to increased risk of suicide, a leading cause of death in this age group. Identifying underlying and modifiable contributors to these conditions is crucial as current research and interventions focus on screening and treatment rather than prevention. Here, we posit that air pollution, in addition to genetic susceptibility, social determinants, familial and school issues, and other factors, is a contributor to mental health disorders. Toxicological studies demonstrate that fine particulate matter (PM2.5) and traffic-related air pollution (TRAP) are neurotoxic, and epidemiologic studies consistently link these pollutants to reduced cognitive abilities and increased externalizing behaviors. However, few studies have prospectively evaluated the role of air pollution exposure on mental health disorders in childhood. Recently, we found that childhood air pollution exposure is associated with increased risk for depression and anxiety at age 12 years. However, the role of air pollution in the onset and persistence of mental health disorders during adolescence, and changes in brain structure, organization, and function linked to these outcomes, remain poorly understood. Therefore, we hypothesize that exposure to air pollution during critical periods of brain development, including adolescence, is associated with adverse mental health outcomes. We will leverage existing longitudinal data from the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS) and the Health Outcomes and Measures of the Environment (HOME) Study, two prospective cohorts located in Cincinnati, Ohio, to address this hypothesis. Both cohorts have been followed from birth and evaluated with concordant measures of mental health and neuroimaging at age 12 years. We will conduct new follow-up at age 18 years to assess the onset and persistence of mental health outcomes through adolescence and apply validated models for PM2.5 and TRAP to characterize air pollution exposure from conception through age 18 years. We will also acquire novel neuroimaging outcomes, including brain -aminobutyric acid and glutathione concentrations accompanied by anatomical and functional magnetic resonance imaging. Our aims are to: 1) determine the association between exposure to PM2.5 and TRAP during distinct developmental periods and the onset and persistence of mental health outcomes in adolescence; 2) determine the association between exposure to PM2.5 and TRAP during distinct developmental periods and neuroimaging outcomes in late adolescence; and 3) determine whether changes in brain volume, organization, metabolism, and function mediate associations between PM2.5 and TRAP exposure and mental health outcomes. Examining air pollution as a novel and modifiable risk factor will provide critical data to guide primary prevention aimed at reducing the burden of mental health disorders in adolescence.

项目摘要 /摘要 超过五分之一的青少年会经历精神健康障碍，包括抑郁和动画， 这些条件的流行率正在增加。在青少年中，抑郁和动画与 自杀的风险增加，这是该年龄段的主要死亡原因。识别基础和修改 对于这些条件的贡献者至关重要，因为当前的研究和干预措施着重于筛查和 治疗而不是预防。在这里，我们海报，除了遗传易感性，社会污染外 决定因素，家庭和学校问题以及其他因素是导致精神疾病的原因。 毒理学研究表明，特定问题（PM2.5）和与交通相关的空气污染（陷阱）是 神经毒性和流行病学研究一致地将这些污染物与降低的认知能力联系起来 增加外在行为。但是，很少有研究对空气污染的作用进行了前瞻性评估 童年时期心理健康障碍的接触。最近，我们发现儿童空气污染的暴露是 与12岁时抑郁症和焦虑症的风险增加有关。但是，空气污染在 青少年期间心理健康障碍的发作和持久性以及大脑结构的变化， 组织以及与这些结果相关的功能仍然知之甚少。因此，我们假设 在包括青少年在内的关键大脑发育期间，暴露于空气污染与 不利的心理健康结果。我们将利用辛辛那提童年的现有纵向数据 过敏和空气污染研究（CCAAP）以及环境的健康结果和措施 （家庭）研究，位于俄亥俄州辛辛那提的两个前瞻性队列，以解决这一假设。两个队列 从出生开始就受到了遵循，并通过一致的心理健康和神经影像措施进行了评估。 年龄12岁。我们将在18岁时进行新的随访，以评估心理的发作和持久性 通过青少年的健康结果，并应用了经过验证的PM2.5的模型，并陷阱以表征空气 从概念到18岁的污染暴露。我们还将获得新颖的神经影像学结果， 包括大脑氨基丁酸和谷胱甘肽浓度通过解剖和功能 磁共振成像。我们的目标是：1）确定接触PM2.5和 在不同的发育时期陷阱以及心理健康成果的发作和持久性 青春期； 2）确定在不同发育过程中暴露于PM2.5和陷阱之间的关联 青少年晚期的时期和神经影像成果； 3）确定大脑体积的变化， PM2.5与陷阱暴露与心理的组织，代谢和功能媒体关联 健康结果。将空气污染作为一种新颖而可修改的风险因素，将提供关键数据来指导 主要预防旨在减少青少年心理健康障碍的燃烧。