14th International Conference on HIV Treatment, Pathogenesis, and Prevention Research (INTEREST)

第14届国际艾滋病毒治疗、发病机制和预防研究会议（INTEREST）

• 批准号: 10012378
• 负责人: Guido Ferrari
• 金额: $ 4.5万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-06 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10012378
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Adherence; Adolescent; Adult; Advisory Committees; Africa; Africa South of the Sahara; African; Age; Award; CD4 Lymphocyte Count; Career Choice; Cessation of life; Child; Clinical; Collaborations; Communities; Development; Diagnosis; Doctor of Philosophy; Early Diagnosis; Ebola; Elderly; Ensure; Epidemic; Event; Fostering; Future; Goals; HIV; HIV Infections; HIV Seropositivity; HIV diagnosis; HIV-1; HIV/TB; Health; Health Care Research; Health Policy; Health Services; Health financing; Hepatitis C; Human Resources; Human immunodeficiency virus test; Individual; Infection; Institutes; International; Investments; Knowledge; Leadership; Leprosy; Malaria; Measures; Oral; Outcome; Pathogenesis; Physicians; Prevention; Prevention Research; Prevention strategy; Public Health; Ramp; Reporting; Research; Research Personnel; Resources; Science; Scientist; Social Work; Training; Travel; Treatment Protocols; Treatment Step; Tuberculosis; Uganda; Viral; Viral Drug Resistance; Viral Load result; Vocational Guidance; Work; Youth; aged; antiretroviral therapy; base; behavioral/social science; career development; clinical care; comorbidity; cost; cost effective; demographics; disparity reduction; effective therapy; evidence base; experience; fight against; girls; global health; implementation science; mHealth; meetings; men; mortality; novel; pandemic disease; pathogen; peer; prevent; programs; research and development; response; scale up; stem; symposium; transmission process; treatment strategy; young woman

Abstract. The most recent UNAIDS estimates of the global burden of HIV are that 36.9 million people are living with HIV-1 infection worldwide, with 69.4% of these residing in sub-Saharan Africa. Markedly, three in four new infections in sub-Saharan Africa are among girls aged 15–19 years and young women aged 15–24 years are twice as likely to be living with HIV than men that age. Further, a striking difference exists between the east/southern and the west/central regions of sub-Saharan Africa, with reductions in AIDS-related deaths since 2010 of 42% and 24%, respectively. Clearly, much work remains in terms of training local physicians and scientists in the diagnosis, treatment, and management of individuals with HIV-1 infection; conducting implementation science to determine the most cost-effective use of financial and human resources; and ensuring evidence-informed public health policy and programming to reduce disparities in the AIDS response across Africa’s sub-regions. Despite treatment likely having contributed to slowing HIV transmission, HIV prevention remains critical to stem the tide of HIV. In fact, a second AIDS pandemic in the next 12 years is predicted due to 1) changing demographics in Africa with increasing numbers of youth, 2) increasing transmitted viral drug resistance, and 3) increased cost and limited availability of 2nd and 3rd line treatment regimens. Taken together, these factors suggest that the total number of people living with AIDS may increase by 2 million/year to reach a staggering 50 million worldwide by 2030. Since 2007, 13 successful annual INTEREST Conferences, known as the ‘African CROI’, have brought together scientists involved in HIV diagnosis and treatment, pathogenesis, and prevention research in resource-limited settings in Africa to share pivotal findings, promote collaboration, and transfer experiences across several fields and many continents. Planning and organization of the 2020 INTEREST Conference will be overseen by the Amsterdam Institute of Global Health and Development. Catherine Hankins MD PhD chairs INTEREST’s International Conference Committee (ICC) and is the Scientific Chair of INTEREST. The organizers of the 2020 INTEREST Conference will pursue the following objectives: 1) To provide cutting-edge knowledge in the fields of diagnosis and treatment, pathogenesis, and prevention of HIV-1 for adults, including the elderly; adolescents; and children living with HIV in Africa, in order to contribute to achieving the 90-90-90 viral suppression goal and to preventing a second great pandemic. 2) To foster new research interactions among leading investigators and those who represent the potential future scientific leadership for health care and research on the African continent.

抽象的。 最近对全球艾滋病毒烧伤的估计是3690万人 全世界都有HIV-1感染，其中69.4％居住在撒哈拉以南非洲。明显地，三个 在撒哈拉以南非洲的四种新感染中，有15-19岁的女孩和年龄的年轻妇女 15-24岁的艾滋病毒的可能性是年龄的男性的两倍。此外，差异很大 存在于撒哈拉以南非洲的东/南/中央地区之间，减少了 自2010年以来，与AIDS相关的死亡分别为42％和24％。显然，就 培训当地医师和科学家，以诊断，治疗和管理 HIV-1感染；进行实施科学以确定财务成本效益的最具用途 和人力资源；并确保有证据的公共卫生政策和编程以减少 非洲子区域的艾滋病反应差异。尽管治疗可能有贡献 为了减缓HIV传播，HIV预防对于阻止HIV的潮流至关重要。实际上，一秒钟 预计未来12年的艾滋病大流行是因为1）非洲的人口统计学变化与 越来越多的年轻人，2）增加传播的病毒耐药性，3）成本增加和 第二线治疗方案的可用性有限。综上所述，这些因素表明 艾滋病的总人数可能会增加200万，以达到惊人的5000万 到2030年全球。 自2007年以来，13个成功的年度兴趣会议，称为“非洲Croi” 一起购买了参与HIV诊断和治疗，发病机理和预防的科学家 非洲资源有限设置的研究，以分享关键发现，促进协作和 在几个领域和许多延续中转移经验。 2020年计划和组织 兴趣会议将由阿姆斯特丹全球卫生与发展研究所监督。 凯瑟琳·汉金斯（Catherine Hankins）MD博士主席的国际会议委员会（ICC），是 感兴趣的科学主席。 2020年利息会议的组织者将追求以下目标： 1）在诊断和治疗，发病机理领域提供最先进的知识， 并预防成年人的HIV-1，包括老年人；青少年；和和生活在一起的孩子 非洲的艾滋病毒，为了实现90-90-90的病毒抑制目标和 防止第二大大流行。 2）促进主要研究人员和代表的研究者之间的新研究互动 非洲大陆的医疗保健和研究的潜在潜在科学领导。