Center for Limb Loss Prevention and Prosthetic Engineering

肢体丧失预防和假肢工程中心

• 批准号: 10043835
• 负责人: Bruce Sangeorzan
• 金额: --
• 依托单位: VA PUGET SOUND HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-10-01 至 2022-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10043835
• 关键词: Address; Amputation; Amputees; Anatomy; Ankle; Arthritis; Award; Book Chapters; Cadaver; Caring; Clinical; Collaborations; Complex; Computer Models; Decision Making; Deformity; Development; Diabetes Mellitus; Diabetic Foot Ulcer; Disease; Doctor of Philosophy; Engineering; Ensure; Environment; Evaluation; Extramural Activities; Flatfoot; Fluoroscopy; Foot Deformities; Funding; Gait; Generations; Goals; Grant; Health Services; Impairment; Informatics; Infrastructure; Injury; Institution; Internships; K-Series Research Career Programs; Laboratories; Lead; Limb structure; Lower Extremity; Magnetic Resonance Imaging; Medical; Medical Students; Medical center; Mental Health; Mission; Modeling; Orthopedics; Pain; Paper; Patients; Peer Review; Physical Medicine; Postdoctoral Fellow; Prevention; Process; Prosthesis; Prosthesis Design; Provider; Psychology; Publishing; Quality of life; Rehabilitation Outcome; Rehabilitation therapy; Research; Research Assistant; Research Personnel; Risk; Robotics; Scientist; Skin injury; Techniques; Technology; Therapeutic Intervention; Training Programs; Trauma; Universities; Veterans; Washington; Work; base; career; comorbidity; design; epidemiology study; evidence base; experimental study; foot; functional outcomes; functional restoration; functional status; graduate student; improved; improved mobility; instrumentation; lectures; loss of function; novel; prevent; psychologic; recruit; rehabilitation research; research and development; research facility; residual limb; restoration; simulation; social; social factors; square foot; symposium; treatment strategy; undergraduate student

PROJECT SUMMARY The mission of our VA Rehabilitation Research and Development Center for Limb Loss Prevention and Prosthetic Engineering is to improve the quality of life and functional status of veterans who are at risk for, or have undergone, a lower extremity amputation. The Center brings together investigative teams that identify clinical problems, model them into hypothesis-driven research, conduct experiments, and make evidence- based conclusions before disseminating the results to veteran, clinical, and scientific audiences. Our Center includes three major cores: (1) Limb Loss Prevention, (2) Prosthetic Engineering, and (3) Rehabilitation Outcomes. The Limb Loss Prevention core aims to reduce functional and anatomical limb loss by studying the disease processes that lead to aberrant limb function and by developing novel, state-of-the-art technologies for studying the foot. Highly specialized techniques, such as biplane fluoroscopy, cadaveric gait simulation, gated MRI loading, and computational modeling, will be employed to quantify the effects of foot deformity, ankle arthritis and diabetes, and to compare the effect of different treatment options. The Prosthetic Engineering core aims are to enhance mobility, reduce the risk of injury, and improve the comfort of veteran amputees. We address these needs by designing and evaluating novel state-of-the-art prostheses that leverage advances in robotics, computation, and instrumentation. The Rehabilitation Outcomes core integrates the complex multi-dimensional issues of medical co-morbidity, psychological status, and social factors and their impact on amputee functional outcome. The development and evaluation of group-based therapeutic interventions, and the improvement of the amputation level decision making process are the foci of this core. Since our last Center renewal in 2012, we have been awarded $5.4M in intramural funding via 15 VA RR&D grants and $3.3M in extramural funding via 6 non-VA federal grants. During the same fiscal period (2013- 2015), the Center has published 69 peer-reviewed articles, 5 book chapters, 3 conference papers, 67 conference abstracts, and our investigators have given 108 presentations and invited lectures. We have also expanded our research capabilities through many successful collaborations with multiple departments at the University of Washington, other top-tier research Universities, leading research institutions, VAPSHCS Health Services, and ERIC (Epidemiology Research an Informatics Center) investigators, as well as clinician/scientists at other VA Medical Centers. Our current 6,300 square feet of laboratory and office space will nearly double, and be transformed into state-of-the-art research facilities when we transition into the new Mental Health and Research Building in 2017. Our Center includes a group of highly productive and recognized senior investigators including two who have won the prestigious Paul B. Magnuson Award for Rehabilitation Research and two recipients of VA Research Career Scientist awards. We have also recruited three early-career PhD researchers and two Career Development Award winners who bring important skillsets to further advance the Center mission. Our Center investigative team includes clinician/scientists with expertise in Orthopaedics, Rehabilitation Medicine, and Rehabilitation Psychology. This strong clinical linkage ensures that our research is relevant to the veteran patients who are the focus of our work. We have developed an impressive training program to create a new generation of scientists who will contribute to veteran care including: undergraduate, graduate and medical students, post-doctoral fellows, interns/residents, and clinical fellows. Our Center’s work is further enhanced by a skilled research team including: MS engineers, research assistants, a biostatistician, and a prosthetist. In summary, this Center has developed a remarkable infrastructure that has enabled it to conduct both high quality, and highly prolific research that is responsive to the emerging needs of our veterans.

项目概要 我们退伍军人管理局康复研究与开发中心预防肢体丧失和 假肢工程旨在改善有以下风险的退伍军人的生活质量和功能状态，或 该中心汇集了调查小组来确定是否接受了下肢截肢手术。 临床问题，将其建模为假设驱动的研究，进行实验并提供证据- 在将结果传播给资深人士、临床和科学受众之前得出结论。 我们的中心包括三个主要核心：（1）肢体丧失预防，（2）假肢工程，以及（3） 康复成果预防肢体丧失的核心目标是减少功能性和解剖性肢体丧失。 通过研究导致肢体功能异常的疾病过程并开发新颖的、最先进的 用于研究足部的高度专业化技术，例如双平面透视、尸体步态。 模拟、门控 MRI 负载和计算建模将用于量化足部的影响 畸形、踝关节关节炎和糖尿病，并比较不同治疗方案的效果。 工程核心目标是增强机动性、降低受伤风险并提高退伍军人的舒适度 我们通过设计和评估利用先进的新型假肢来满足这些需求。 康复成果核心集成了机器人技术、计算和仪器方面的进步。 医疗共病、心理状态和社会因素等复杂的多维问题及其影响 对截肢者功能结果的影响。基于团体的治疗的开发和评估。 干预措施以及截肢水平决策过程的改进是该核心的重点。 自 2012 年上次中心更新以来，我们已通过 15 VA RR&D 获得了 540 万美元的校内资金 同一财政期间（2013 年至今）通过 6 项非 VA 联邦拨款获得 330 万美元的外部资金。 2015），中心已发表 69 篇同行评审文章、5 个书籍章节、3 篇会议论文、67 场会议 摘要，我们的研究人员进行了 108 场演讲和特邀讲座。 通过与大学多个部门的多次成功合作，增强了研究能力 华盛顿州、其他顶级研究型大学、领先的研究机构、VAPSHCS 健康服务中心和 ERIC（流行病学研究和信息学中心）研究人员以及其他 VA 的临床医生/科学家 我们目前 6,300 平方英尺的实验室和办公空间将几乎增加一倍，并且 当我们过渡到新的心理健康和 研究大楼2017年。 我们的中心拥有一批高产且受认可的高级研究人员，其中两名拥有 荣获著名的 Paul B. Magnuson 康复研究奖和 VA Research 的两名获奖者 我们还招募了三名早期职业博士研究人员和两名职业科学家。 发展奖获得者带来了进一步推进中心使命的重要技能。 研究团队包括具有骨科、康复医学和医学专业知识的临床医生/科学家 这种强大的临床联系确保我们的研究与退伍军人相关。 我们制定了令人印象深刻的培训计划来创建新的患者。 将为退伍军人护理做出贡献的一代科学家，包括：本科生、研究生和医学生 学生、博士后研究员、实习生/住院医师和临床研究员的工作得到进一步加强。 由技术精湛的研究团队负责，其中包括：多发性硬化症工程师、研究助理、生物统计学家和假肢师。 总之，该中心开发了卓越的基础设施，使其能够开展高 高质量、高产的研究，满足我们退伍军人的新需求。