Sensory Augmentation, Restoration, and Modulation Using a Spinal Neuroprosthesis

使用脊柱神经假体进行感觉增强、恢复和调节

• 批准号: 10687329
• 负责人: Amol P Yadav
• 金额: $ 137.97万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-07 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10687329
• 关键词: Acceleration; Address; Affect; American; Amputees; Animals; Brain; Clinical; Cues; Development; Devices; Disease; Electromagnetics; Environment; Esthesia; FDA approved; Feasibility Studies; Goals; Human; Individual; Injury; Intuition; Just-Noticeable Differences; Learning; Life; Limb Prosthesis; Location; Locomotion; Lower Extremity; Macaca mulatta; Methods; Movement; Nervous System Trauma; Neurologic; Neurostimulation procedures of spinal cord tissue; Numbness; Patients; Perception; Quality of life; Rehabilitation therapy; Research; Research Personnel; Rodent; Sensory; Signal Transduction; Spinal; Spinal Cord; Spinal cord injury; Stroke; Technology; Testing; Time; Training; Traumatic Brain Injury; Ultraviolet Rays; Variant; Vertebral column; brain machine interface; chronic pain management; clinical translation; experimental study; human subject; implantation; infancy; innovation; limb amputation; magnetic field; motor control; nervous system disorder; neuroprosthesis; non-Native; novel; pre-clinical; prevent; restoration; sensory feedback; standard of care; transmission process; Acceleration; Address; Affect; American; Amputees; Animals; Brain; Clinical; Cues; Development; Devices; Disease; Electromagnetics; Environment; Esthesia; FDA approved; Feasibility Studies; Goals; Human; Individual; Injury; Intuition; Just-Noticeable Differences; Learning; Life; Limb Prosthesis; Location; Locomotion; Lower Extremity; Macaca mulatta; Methods; Movement; Nervous System Trauma; Neurologic; Neurostimulation procedures of spinal cord tissue; Numbness; Patients; Perception; Quality of life; Rehabilitation therapy; Research; Research Personnel; Rodent; Sensory; Signal Transduction; Spinal; Spinal Cord; Spinal cord injury; Stroke; Technology; Testing; Time; Training; Traumatic Brain Injury; Ultraviolet Rays; Variant; Vertebral column; brain machine interface; chronic pain management; clinical translation; experimental study; human subject; implantation; infancy; innovation; limb amputation; magnetic field; motor control; nervous system disorder; neuroprosthesis; non-Native; novel; pre-clinical; prevent; restoration; sensory feedback; standard of care; transmission process

Project Summary The physical world contains signals encompassing the entire electromagnetic spectrum, and yet human perception of the world is limited to our five senses. To augment our senses, it is essential to first develop methods that can effectively transmit high-bandwidth information to the brain. Researchers working on brain- machine interfaces have successfully extracted movement signals from the brain to control external devices. Yet, methods that augment, restore, or modulate sensory perception are currently limited. Lack of real-time sensory feedback from a brain-machine interface or neuroprosthetic device prevents optimal motor control and thus limits sensorimotor rehabilitation. Loss of sensation due to life-altering injuries and disorders affects the quality of life of millions of Americans. Thus, methods that mimic sensory signals and interface them directly with the brain are an unmet clinical need. This project proposes a novel spinal sensory neuroprosthetic interface using sensory spinal cord stimulation (SSCS) with the ability to augment, restore, and modulate sensory perceptions. This radically innovative approach has the potential to impact a wide array of neurological conditions by addressing sensory restoration and allows for the exploration of the limits of human sensory perception. Pre- clinical experiments in rodents and rhesus monkeys demonstrated that animals learn to detect and discriminate artificial sensations induced by SSCS. To achieve clinical translation of SSCS technology, this proposal involves a feasibility study, conducted in patients undergoing spinal cord stimulator implantation for the treatment of chronic pain. First, the relationship between SSCS-induced sensory perceptual thresholds, just-noticeable differences, and stimulation parameters will be established (Goal 1). Second, human subjects will be trained to detect and discriminate variations in signal intensity and orientation of non-native signals such as infrared, UV light, magnetic fields, etc. using SSCS-induced perceptual sense, and ultimately subjects will learn to use these novel perceptual abilities to navigate a spatial environment with non-native signal cues (Goal 2). Third, lower limb amputee subjects will learn to intuitively perceive movement and location of their prosthetic limbs during locomotion via real-time closed loop sensory feedback using SSCS (Goal 3). This project is innovative because it uses FDA-approved technology (spinal cord stimulation) in a new context, all without changing the patient’s standard-of-care. The ability to augment, restore, and modulate perceptions will be an unprecedented development in the field of sensory neuroprosthetics. Successful execution of proposed goals will not only launch a new line of augmentation research, but it will also showcase that SSCS can be widely applicable in the rehabilitation of patients suffering from sensory deficits due to neurological disorders and injuries.

项目摘要 物理世界包含包含整个电子光谱的信号，但人类 对世界的看法仅限于我们的五种感官。为了增强我们的感官，必须首先发展 可以有效地将高带宽信息传输到大脑的方法。研究大脑的研究人员 机器界面已成功从大脑中提取运动信号以控制外部设备。 然而，目前有限的方法可以增加，恢复或调节感官感知。缺乏实时 来自脑机界面或神经假体设备的感觉反馈可防止最佳运动控制和 因此限制了感觉运动康复。因改变生活的伤害和疾病而引起的感觉的丧失会影响 数百万美国人的生活质量。那就是模仿感官信号并将它们直接与之接口的方法 大脑是未满足的临床需求。该项目提出了一种新型的脊柱感觉神经假体界面 使用感官脊髓刺激（SSC），具有增强，恢复和调节感觉的能力 感知。这种根本创新的方法有可能影响广泛的神经条件 通过解决感觉恢复并允许探索人类感觉知觉的局限性。 pre 啮齿动物和恒河猴的临床实验表明，动物学会了检测和歧视 SSC诱导的人造感觉。为了实现SSCS技术的临床翻译，该建议涉及 一项可行性研究，在接受脊髓刺激剂实施的患者中进行治疗 慢性疼痛。首先，SSC诱导的感觉感知阈值之间的关系，恰好感染了 将建立差异和刺激参数（目标1）。其次，人类受试者将接受培训 检测和区分非本地信号（例如感染，紫外线）的信号强度和方向的变化 光，磁场等。使用SSCS引起的感知意义，最终将学会使用这些。 具有非本地信号提示的空间环境导航的新型感知能力（目标2）。第三，较低 肢体截肢者将学会在直觉上感知运动及其假肢的位置 使用SSC进行实时闭环感觉反馈的运动（目标3）。这个项目是创新的，因为 它在新的情况下使用FDA批准的技术（脊髓刺激），而无需改变患者的 护理标准。增强，恢复和调制感知的能力将是前所未有的 在感觉神经假想领域的发展。成功执行拟议的目标不仅将启动 一项新的增强研究系列，但还将展示SSC可以广泛适用于 由于神经系统疾病和损伤而导致的感觉缺陷患者的康复。