Expanding xenosurveillance capabilities in central America

扩大中美洲的异种监视能力

基本信息

批准号：
10041581
负责人：
Gregory David Ebel
金额：
$ 23.77万
依托单位：
COLORADO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-11 至 2022-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10041581
关键词：
Ache Affect Africa Americas Anger Animals Bite Blood Blood capillaries Blood specimen Central America Child Clinical Data Clinical Medicine Communicable Diseases Communities Culicidae Data Detection Devices Disease Domestic Animals Ebola virus Emerging Communicable Diseases Enrollment Entomology Environment Epidemic Exanthema Fever Frequencies Guatemala Hate Health Home environment Hour Household Human Laboratories Laboratory Study Latin America Methodology Methods Middle East Middle East Respiratory Syndrome Coronavirus Midgut Mind Monitor Needles Pain Paper Pathogen detection Performance Pilot Projects Population Process Public Health Quantitative Reverse Transcriptase PCR RNA Reporting Resources Rural Sampling Site Spottings Symptoms Syndrome System Temperature Time Validation Venipunctures Venous blood sampling Veterinarians Veterinary Medicine Viral Visiting Nurse Work Yellow fever virus Zoonoses base burden of illness cohort design field study health economics innovation insight member minimally invasive multidisciplinary next generation sequencing pandemic disease pathogen prospective surveillance data syndromic surveillance tool transmission process virology

项目摘要

This proposal is for an R21, Expanding xenosurveillance capabilities in Central America. The project is a highly multidisciplinary effort that includes collaborators with expertise in virology, public health entomology, surveillance, and human clinical and veterinary medicine. Our study is based on the idea that mosquitoes can serve as surveillance tools because they are essentially autonomous blood sampling devices. Freshly fed mosquitoes are collected from within dwellings and blood is used for surveillance purposes. If successful, our work would have the impact of simplifying certain types of surveillance that require human blood because although most people hate it when they and their children are stuck with needles, they don’t seem to mind mosquitoes being removed from within their homes. In addition, our approach has the potential to make sampling from animals safer by vastly reducing the need for direct contact with fearful and angry animals that bite, kick, etc.. Aim 1 focuses on validating xenosurveillance through a direct comparison to human-based syndromic surveillance. Aim 2 is designed to maintain the scientific rigor of our work by obtaining quantitative estimates of the sensitivity of Cx. quinquefasciatus and Ae. aegypti for xenosurveillance. This proposal leverages significant prior work on xenosurveillance that has focused on An. gambiae in W. Africa, and an ongoing pilot study of xenosurveillance in rural Guatemala.

该建议是针对R21的，扩大了中美洲的异种监视能力。该项目是一个高度多学科的努力包括具有病毒学专业知识，公共卫生昆虫学专业知识的合作者，监视以及人类的临床和兽医医学。我们的研究基于蚊子可以用作监视工具，因为它们本质上是自主抽样设备。新鲜喂养从住宅内收集蚊子，并将血液用于监测目的。如果成功，我们的工作将具有简化某些需要人类血液的监视的影响，因为尽管大多数人在他们和他们的孩子被针头扎在时都讨厌它，但他们似乎并不介意蚊子从他们的家中移走。此外，我们的方法有可能使通过大大减少了与可怕和愤怒的动物直接接触的需求，从动物中取样更安全咬，踢等。 AIM 1专注于通过与人类综合征直接比较来验证异种监视监视。 AIM 2旨在通过获得定量估计来维持我们工作的科学严谨性。 CX的灵敏度。 Quinquefasciatus和Ae。埃及为异种监视。该提议利用了针对AN的异种监视的重要事务。冈比亚在W. 非洲，以及一项正在进行的危地马拉乡村异种监视的试点研究。