PDX Core

PDX核心

基本信息

批准号：
10013164
负责人：
Vito William Rebecca
金额：
$ 2万
依托单位：
WISTAR INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10013164
关键词：
Biological Biological Assay Biological Models Cell Line Cells Cellular biology Clinical Collaborations Collagen Communicable Diseases DNA Data Data Storage and Retrieval Databases Disease Ensure Freezing Future Genetic Genetic Fingerprintings Human Immunodeficient Mouse In Vitro Laboratories Lesion Medical Genetics Melanoma Cell Methodology Modeling Molecular Molecular Abnormality Monitor Mus Neoplasm Metastasis Patients Pilot Projects Proteins Quality Control RNA Reproducibility Research Research Personnel Research Project Grants Resources Scientist Seeds Services Skin Testing Training Validation cell bank experimental study in vitro Model in vivo Model investigator training melanoma member neoplastic cell novel therapeutics pathogen preclinical study programs protein expression screening success three-dimensional modeling tool tumor tumor growth

项目摘要

Project Summary – PDX Core The PDX Core provides major resources to the program investigators, including melanoma PDX, melanoma cell lines and 3D models to explore new therapies. The melanoma PDX encompasses >450 different tumors representing all clinical and genetic groups of the disease. The primary focus of the PDX core is to establish new PDX and coordinate their characterization at the DNA, RNA, and protein levels. It then maintains the master cell bank, monitors for mouse pathogens, and collaborates with other investigators within the program, within the overall PDTC and outside scientists. The Core is also to central facilitator for exchanging PDX within the PDXNet for a coordinated effort on collaborations. The Core coordinates data storage and distribution to other investigators within the Program. The PDX Core is available to train investigators of the Program in all biological assays and models. Overall, this Core will provide efficient and high-quality service to all laboratories within this PDTC. 1

项目摘要 – PDX 核心 PDX 核心为项目研究人员提供主要资源，包括黑色素瘤 PDX、黑色素瘤细胞系和 3D 模型来探索新疗法黑色素瘤 PDX 涵盖超过 450 种不同的肿瘤。代表疾病的所有临床和遗传群体。 PDX 核心的主要重点是建立。新的 PDX 并在 DNA、RNA 和蛋白质水平上协调它们的表征，然后维持。主细胞库，监测小鼠病原体，并与该计划内的其他研究人员合作，核心也是整个 PDTC 和外部科学家之间交换 PDX 的中心促进者。 PDXNet 旨在协调协作的数据存储和分发。该计划内的其他调查员。 PDX 核心可用于培训该计划的研究人员进行所有生物测定和模型。该核心将为PDTC内的所有实验室提供高效、高质量的服务。 1