Studies of Thyroid Function in Health and Disease

健康和疾病中的甲状腺功能研究

• 批准号: 10011456
• 负责人: Joanna Klubo-Gwiezdzinska
• 金额: $ 5.23万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10011456
• 关键词: Age; Antibodies; Autoimmunity; Binding Proteins; Biological; Biological Assay; Blood; Board Certification; Body Composition; Clinical; Diagnosis; Diagnostic Procedure; Differentiation and Growth; Discipline of Nuclear Medicine; Disease; Endocrine; Endocrinology; Energy Metabolism; Enrollment; Etiology; Failure; Family history of; Functional disorder; Genetic; Graves' Disease; Health; Hyperthyroidism; Hyperthyroxinemia; Hypothalamic Hormones; Hypothalamic structure; Hypothyroidism; Iatrogenesis; Immunoassay; Institutes; Iodides; Laboratories; Laboratory Study; Magnetic Resonance Imaging; Measurement; Metabolism; Natural History; Patients; Pattern; Physical Examination; Pituitary Gland; Pituitary Neoplasms; Prolactinoma; Protocols documentation; Public Health; Radioactive Iodine; Recording of previous events; Recruitment Activity; Reflex action; Resistance; Scanning; Secondary to; Serum; Signs and Symptoms; Somatotropin; Spectrophotometry; Subacute thyroiditis; Technetium; Testing; Thyroid Diseases; Thyroid Function Tests; Thyroid Gland; Thyroid Hormones; Thyroid Nodule; Thyroid Stimulating Hormone Secreting Pituitary Gland Adenoma; Thyroiditis; Thyrotropin-Releasing Hormone; Thyroxine-Binding Globulin; Training; Training Programs; Trophoblastic Neoplasms; United States National Institutes of Health; Urine; X-Ray Computed Tomography; cell growth; cohort; diagnostic accuracy; glycosylation; imaging study; patient screening; receptor; research study; tumor; uptake

Subjects of any age with known or suspected thyroid abnormalities are actively recruited to this natural history protocol. The disorders studied can be broadly defined as hyper- or hypothyroid states and laboratory abnormalities. Hyperthyroid states include but are not restricted to Graves' disease with or without extrathyroidal manifestations; subacute thyroiditis; silent thyroiditis; single or multiple hyperfunctioning thyroid nodules; iodide-induced hyperthyroidism; surreptitious administration of thyroid hormone; trophoblastic neoplasms; "inappropriate" secretion of TSH arising from TSH- producing pituitary tumors or from a non-neoplastic cause, i.e. pituitary resistance to the action of thyroid hormone. Hypothyroid states include primary thyroid failure due to agenesis, autoimmunity or iatrogenic causes; secondary (or pituitary) hypothyroidism, usually resulting from tumors of the pituitary of non-thyrotropic origin such, as growth hormone (GH)-secreting tumors or prolactinomas; tertiary (or hypothalamic) hypothyroidism, usually resulting from a deficiency in the hypothalamic hormone thyrotropin-releasing hormone (TRH), either of unknown etiology or secondary to a pituitary tumor; bio-inactive TSH, either relating to an endogenous abnormality of hypothalamic hormones or secondary to pituitary tumors (and usually related to abnormal glycosylation patterns of the TSH molecule); generalized resistance to thyroid hormone (RTH), a disease which has been shown to be due to abnormalities in the TH receptor. Additionally, conditions or states that result in abnormal thyroid function tests are studied including non-thyroidal illness; abnormalities of serum TH binding proteins leading to euthyroid hyperthyroxinemia or hypertriiodothyronemia; genetic deficiency of thyroxine-binding globulin (TBG); antibody interference in TSH or other thyroid hormone assays. Recently, reflex mass spectrophotometry is utilized to further diagnose the thyroid dysfunction in this cohort of patients, thus enabling comparison of diagnostic accuracy between the mass spectrophotometry and standard immunoassays in diagnosing thyroid disorders.

已知或疑似甲状腺异常的任何年龄的受试者都被积极招募到该自然史方案中。 研究的疾病可广义地定义为甲状腺功能亢进或甲状腺功能减退状态以及实验室异常。 甲状腺功能亢进状态包括但不限于伴有或不伴有甲状腺外表现的格雷夫斯病；亚急性甲状腺炎;无症状甲状腺炎;单个或多个甲状腺功能亢进结节；碘引起的甲状腺功能亢进；秘密施用甲状腺激素；滋养细胞肿瘤；由产生 TSH 的垂体肿瘤或非肿瘤原因（即垂体对甲状腺激素作用的抵抗）引起的 TSH“不适当”分泌。 甲状腺功能减退状态包括由于发育不全、自身免疫或医源性原因导致的原发性甲状腺功能衰竭；继发性（或垂体）甲状腺功能减退症，通常由非促甲状腺来源的垂体肿瘤引起，例如生长激素（GH）分泌肿瘤或催乳素瘤；三级（或下丘脑）甲状腺功能减退症，通常由下丘脑激素促甲状腺素释放激素（TRH）缺乏引起，病因不明或继发于垂体肿瘤；生物无活性 TSH，与下丘脑激素的内源性异常有关或继发于垂体肿瘤（通常与 TSH 分子的异常糖基化模式有关）； 对甲状腺激素 (RTH) 的普遍抵抗，这种疾病已被证明是由于 TH 受体异常引起的。 此外，还研究了导致甲状腺功能测试异常的病症或状态，包括非甲状腺疾病；血清 TH 结合蛋白异常导致甲状腺功能正常的高甲状腺素血症或高三碘甲状腺素血症； 甲状腺素结合球蛋白（TBG）遗传缺陷； 抗体干扰 TSH 或其他甲状腺激素测定。最近，反射质谱法被用来进一步诊断这组患者的甲状腺功能障碍，从而可以比较质谱法和标准免疫分析在诊断甲状腺疾病时的诊断准确性。