Understanding Cardiovascular Disease Mechanisms

了解心血管疾病机制

• 批准号: 10009722
• 负责人: Evangelia G Kranias
• 金额: $ 35.07万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-12-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10009722
• 关键词: Cardiovascular Diseases

ABSTRACT This is a first renewal application for a pre- and postdoctoral training program, the title and theme of which is “Understanding Cardiovascular Disease Mechanisms”. The University of Cincinnati and Children’s Hospital has a renowned legacy spanning more than 4 decades of previous NIH T32 support for cardiovascular study, and this current T32 represents the only CV program in Cincinnati. Our collective 18 faculty in this renewal have placed 238 of their past trainees into academics over their careers, 153 of whom have run, or currently run independent research programs. In the past 4 years of this program, our 17 trainees published 43 papers and 5 received independent grant funding during their support period, while 5 graduates have matriculated to jobs in scientific careers. The overall scientific emphasis of our training program will continue to build from a basic platform of cardiovascular physiology, cell biology, biochemistry and pharmacology, but will also incorporate the latest approaches in biomedical research, as well as incorporating clinical and translational approaches. The cardiovascular environment at Cincinnati Children’s and the University of Cincinnati is considered one of the very best in the country. Our 18 TG faculty are all NIH funded (some 47 NIH funding components amongst them as PI status), 165 collaborative papers published together, and they are employing the very latest technologies and approaches with outstanding core support. The leadership consists of the co- PIs Drs. Evangelia Kranias and Jeffery Molkentin, both of whom have a long track record of working together (20 years), as well as having excellent mentorship credentials. The Executive Committee (2 members), Internal Advisory Committee (4 members) and External Advisory Committee (3 members) are highly engaged cardiovascular researchers who will continue to help ensure the quality of the training program. The renewal requests continuation of the funding of 3 pre- and 3 postdoctoral trainee positions. Predocs are selected by the Internal Advisory Committee from a vast and outstanding pool of candidates amongst 7 departmental graduate programs, while postdoctoral candidates are selected based on being accepted into a mentor’s laboratory and then passing the screening process by the Internal Advisory Committee and co-PIs. The mentoring program and evaluation process for the program are highly structured and oversight occurs on many levels. Trainees and mentors are evaluated every 6 months with IDPs processing. The proposed educational training curriculum is highly structured and state-of-the-art. Recruitment of minorities has been successful in the past with our faculty, and it will remain a top priority.

抽象的 这是对博士后和博士后培训计划的第一个续订申请，其标题和主题是 “了解心血管疾病机制”。辛辛那提大学和儿童医院 拥有著名的遗产，涵盖了超过40年的NIH T32对心血管研究的支持， 当前的T32代表了辛辛那提中唯一的简历程序。我们的集体18教师 已经将过去238名过去的学员纳入了学者，其中153名跑步或目前 运行独立的研究计划。在该计划的过去4年中，我们的17名学员发表了43篇论文 5人在他们的支持期内获得了独立赠款资金，而5名毕业生已归类为 科学职业的工作。我们的培训计划的整体科学重点将继续从 心血管生理学，细胞生物学，生物化学和药理学的基本平台，但也将 结合了生物医学研究中的最新方法，以及融合的临床和翻译 方法。辛辛那提儿童和辛辛那提大学的心血管环境是 被认为是该国最好的之一。我们的18个TG教师都是NIH资助的（大约47个NIH资金 其中的组成部分为PI状态），共同发表了165篇合作论文，他们正在采用 最新的技术和方法具有出色的核心支持。领导包括共同 pis drs。 Evangelia Kranias和Jeffery Molkentin，他们都有很长的记录 （20年），以及具有出色的心态证书。执行委员会（2个成员）， 内部咨询委员会（4个成员）和外部咨询委员会（3个成员）高度参与 心血管研究人员将继续帮助确保培训计划的质量。更新 请求延续3个前和3个博士后学员职位的资金。 predoc是由 7个部门毕业生中的大量候选人库的内部咨询委员会 计划，而在基于精神实验室接受的博士后候选人和 然后通过内部咨询委员会和Co-Pis通过筛选过程。心理计划 该计划的评估过程是高度结构化的，并且在许多层面上进行监督。学员 通过IDP处理，每6个月对导师进行一次评估。拟议的教育培训 课程是高度结构化的，并且是最先进的。过去的少数民族招募成功 有了我们的教师，这将仍然是重中之重。