Understanding Cardiovascular Disease Mechanisms

了解心血管疾病机制

• 批准号: 8793244
• 负责人: Evangelia G Kranias
• 金额: $ 29.72万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-12-01 至 2019-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8793244
• 关键词: Cardiovascular Diseases

 DESCRIPTION (provided by applicant): This is a new application for a pre- and postdoctoral training program, the title and theme of which is "Understanding Cardiovascular Disease Mechanisms". While this is a new T32 application, the cardiovascular training program at the University of Cincinnati and Children's Hospital has a renowned legacy due to 35 years of previous NIH T32 support under Dr. Arnold Schwartz (recently not renewed). The new leadership proposed here, together with a more focused and highly funded faculty wish to carry on this proud tradition of excellence in cardiovascular research and mentorship for another 35 years in Cincinnati. Our collective 19 faculty has placed 297 of their past trainees into academics over their careers, 154 of whom have run, or currently run independent research programs. The overall scientific emphasis of our training program will continue to build from a basic platform of cardiovascular physiology, cell biology, biochemistry and pharmacology, but will also incorporate the latest approaches in the post genomic era, as well as incorporating clinical and translational approaches. The cardiovascular environment at Cincinnati Children's and the University of Cincinnati is considered one of the very best in the country, with 19 NIH funded faculty (some 49 NIH grants amongst them as PI status), 166 collaborative papers published in 10 years, and the very latest technologies and approaches with outstanding core support. The leadership consists of the co-PIs Drs. Evangelia Kranias and Jeffery D. Molkentin, both of whom have a long standing track record of working closely together (15 years), as well as having excellent mentorship credentials. The Executive Committee (2 members), Internal Advisory Committee (4 members) and External Advisory Committee (3 members) are highly engaged cardiovascular researchers who will help ensure the quality of the training program. The current proposal requests funding for 3 pre- and 3 postdoctoral trainees. Predocs are selected by the Internal Advisory Committee from a wide pool arising from departmental graduate programs, while postdoctoral candidates are selected based on being accepted into a mentor's laboratory and then passing the screening process by the Internal Advisory Committee and co-PIs. The mentoring program and evaluation process for the program are highly structured and oversight occurs on many levels. Trainees and mentors are evaluated every 6 months. The proposed educational training curriculum is highly structured and state-of-the-art. Recruitment of minorities has also been successful in the past with our faculty, and it will remain a top priority.

 描述（由应用程序提供）：这是一个新的应用程序和博士后培训计划，其标题和主题是“了解心血管疾病机制”。虽然这是一个新的T32应用程序，但辛辛那提大学和儿童医院的心血管培训计划因Arnold Schwartz博士的前35年的NIH T32支持而具有著名的遗产（最近未续签）。在这里提出的新领导以及更加集中和资助的教职员工希望在辛辛那提继续35年的心血管研究和心态卓越的传统。我们的Collective 19教职员工将过去的297名学员纳入了学者，其中154名已经跑步或目前开展了独立的研究计划。我们的培训计划的总体科学重点将继续建立在心血管生理学，细胞生物学，生物化学和药理学的基本平台上，但还将结合基因组时代后的最新方法，以及结合了临床和翻译方法。辛辛那提儿童和辛辛那提大学的心血管环境被认为是该国最好的人物之一，有19名NIH资助的教师（其中约有49个NIH赠款为PI状态），166份合作论文在10年内发表，并且是最新的技术和杰出的核心支持。领导由Co-Pis Drs组成。 Evangelia Kranias和Jeffery D. Molkentin都有很长的良好记录，即紧密合作（15年），并且具有出色的心态资格。执行委员会（2名成员），内部咨询委员会（4个成员）和外部咨询委员会（3个成员）是高度参与的心血管研究人员，他们将有助于确保培训计划的质量。当前的提案要求为3名前和3名博士后学员提供资金。内部咨询委员会是由部门研究生计划引起的宽池的内部咨询委员会选择的，而博士后候选人的选择是基于被接受为精神实验室的，然后由内部咨询委员会和共同案件通过筛查过程。该计划的心理计划和评估过程是高度结构化的，并且在许多层面上进行了监督。每6个月评估学员和精神。拟议的教育培训课程是高度结构化和最先进的。过去，少数民族的招募也已经与我们的教职员工取得了成功，它将继续 重点。