Development of An Optoelectronically Active Bioink

光电活性生物墨水的开发

• 批准号: 10042762
• 负责人: Cunjiang Yu
• 金额: $ 10.78万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10042762
• 关键词: 3-Dimensional; Address; Behavior; Biocompatible Materials; Biologic Development; Biology; Blood; Cardiac; Cardiac Myocytes; Cells; Characteristics; Development; Devices; Electric Stimulation; Electrodes; Electronics; Electrophysiology (science); Ensure; Environment; Formulation; Genetic Engineering; Goals; Harvest; Heart; Heart Diseases; Hybrids; Hydrogels; In Situ; In Vitro; Lighting; Metabolic Pump; Methods; Organ; Performance; Process; Property; Regenerative Medicine; Research Personnel; Safety; Scheme; Shapes; Signal Transduction; Silicon; Structure; Thick; Thinness; Tissue Engineering; Tissues; Vascular System; base; biofabrication; biomaterial compatibility; bioprinting; cardiac regeneration; cardiac tissue engineering; design; experience; healing; heart function; improved; injured; mechanical properties; multidisciplinary; optogenetics; physical property; submicron; tissue regeneration

Project Summary As one of the most vital organs, the heart functions as a potent biological pump that actively delivers/recycles the blood towards/from all other organs through the vascular system. It has always been a focus in healing an injured or diseased heart through tissue engineering and regenerative medicine. With many years of endeavors, the field of cardiac tissue engineering has seen tremendous progress in fabricating functional cardiac tissues that to a great extent recapitulate the biology of the heart, but challenges remain. The alignment of cardiomyocytes and their organization into bundles characterized by spontaneous and synchronous contraction complicate the development of biologically relevant cardiac tissues. Maturation and contraction of the cardiomyocytes poses another major obstacle. The overall goal of this proposed project is to develop an optoelectronically active bioink that will enable effective maturation and on-demand pacing of the bioprinted cardiac tissues through untethered and remote photo-illumination, in order to address the unmet urgent needs in bioprinting cardiac tissues with embedded, remote stimulation/pacing functions. The bioink will allow for electrical conversion of photoenergy through integration of μ-solar cells in the form of ultra-thin pellets for in situ photo induced electrical stimulation, where the pellets will also be designed to be biodegradable to match the rate of tissue maturation.

项目概要 作为最重要的器官之一，心脏充当强大的生物泵，积极输送/回收 通过血管系统流向/来自所有其他器官的血液一直是治疗的焦点。 多年来通过组织工程和再生医学治疗受伤或患病的心脏。 经过努力，心脏组织工程领域在制造功能性材料方面取得了巨大进展 心脏组织在很大程度上概括了心脏的生物学特性，但挑战仍然存在。 心肌细胞及其组织排列成束，其特征在于自发和 同步收缩使生物学相关的心脏组织的成熟和发育变得复杂。 心肌细胞的收缩造成了另一个主要障碍。该项目的总体目标是 开发一种光电活性生物墨水，使生物墨水能够有效成熟并按需调节 通过不受束缚的远程光照明生物打印心脏组织，以解决未满足的问题 生物打印心脏组织具有嵌入式远程刺激/起搏功能的迫切需求。 通过集成超薄颗粒形式的 μ 太阳能电池，实现光能的电转换 用于原位光诱导电刺激，其中颗粒也将被设计为可生物降解的 与组织成熟的速度相匹配。