Gastric Electrical Slow Wave Functional MRI of the Human Brain

人脑胃电慢波功能 MRI

• 批准号: 10039901
• 负责人: JAMES J. PEKAR
• 金额: $ 44.59万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10039901
• 关键词: Abdomen; Accounting; Adult; Anorexia; Area; Biological Markers; Blood Glucose; Brain; Brain region; Clinical; Communication; Data; Development; Dorsal; Eating Disorders; Electrodes; Electroencephalography; Endocrine; Enteric Nervous System; Etiology; Fasting; Feedback; Frequencies; Functional Magnetic Resonance Imaging; Ganglia; Goals; Hour; Human; Imaging technology; Immune; Interstitial Cell of Cajal; Intestines; Lead; Magnetic Resonance Imaging; Magnetoencephalography; Measures; Methods; Modeling; Monitor; Motor Cortex; National Institute of Biomedical Imaging and Bioengineering; Nerve; Neuraxis; Neurons; Obesity; Pacemakers; Parasympathetic Nervous System; Participant; Pelvis; Peristalsis; Phase; Physiological; Population; Reporting; Research Project Grants; Rest; Scalp structure; Sensitivity and Specificity; Skin; Splanchnic Nerves; Stomach; Surface; Sympathetic Nervous System; Vagus nerve structure; Variant; Viscera; blood oxygen level dependent; cell motility; extrastriate; functional MRI scan; gut-brain axis; hemodynamics; imaging study; improved; neuroimaging; new technology; novel; novel marker; programs; relating to nervous system; transmission process; volunteer

Gastric Electrical Slow Wave Functional MRI of the Human Brain “Resting-state” fMRI (rsfMRI) is a noninvasive neuroimaging method that uses MRI acquisitions optimized for monitoring hemodynamic sequelae of task-evoked changes in brain activity (blood oxygenation level dependent or BOLD, task-fMRI) to observe activity in the brain “at rest”. The resulting MRI data manifest what are generally regarded as spontaneous fluctuations in intrinsic brain networks, allowing study of functional connectivity. Such phenomena may offer novel biomarkers for clinical populations, if they can be assessed without interference from other MRI effects and physiological phenomena. A recent report combining concurrent surface electrogastrography (EGG) and rsfMRI shows that the electrical slow wave (normogastric period of about 20 seconds), generated by interstitial cells of Cajal in the stomach, appears to drive activity in a brain “gastric network” including somato-motor cortices, dorsal precuneus, and the extrastriate body area. This observation that significant brain activity is not “spontaneous” in the sense of originating in the brain, but rather is driven by a “pacemaker” in the stomach, can be seen in two complementary ways: Either as a nuisance that confounds rsfMRI – suggesting the goal of modeling and reducing these effects – or as introducing a new technology for study of the embodied brain – suggesting the complementary goal of exploiting these effects. We will pursue three aims: 1. Estimate and reduce contributions of the slow gastric rhythm to established rsfMRI metrics. 2. Demonstrate whether controlling gastric state – fasted vs. fed – can reduce the impact of the gastric rhythm on established rsfMRI metrics. 3. Characterize the effects of gastric rhythm and state on the gastric network, and other brain regions. Accounting for brain activity driven by the basal gastric rhythm will enhance the ability to study spontaneous fluctuations in the brain's intrinsic networks, by allowing for the modeling of hitherto unexplained variability. Controlling gastric state has the potential to improve statistical power by reducing inter-session and inter-subject variance. Characterizing the effects of gastric rhythm and state on the brain will yield new measures of stomach/brain interactions, that could lead to novel studies in eating disorders ranging from anorexia to obesity.

人脑胃电慢波功能 MRI “静息态”fMRI (rsfMRI) 是一种无创神经成像方法，它使用针对以下情况优化的 MRI 采集： 监测任务引起的大脑活动变化的血流动力学后遗症（血氧水平 依赖或大胆，任务功能磁共振成像）来观察“休息时”大脑的活动，由此产生的 MRI 数据表明了什么。 通常被认为是内在大脑网络的自发波动，允许对功能进行研究 如果可以评估这种现象，可能会为临床人群提供新的生物标志物。 不受其他 MRI 效应和生理现象的干扰。 同时进行的表面胃电图 (EGG) 和 rsfMRI 显示电慢波（正常胃 大约 20 秒的时间），由胃中的 Cajal 间质细胞产生，似乎驱动 大脑“胃网络”包括躯体运动皮质、背侧楔前叶和纹状体区域。 观察发现，重要的大脑活动并不是起源于大脑意义上的“自发”，而是 由胃中的“起搏器”驱动，可以通过两种互补的方式来看待：要么作为一种滋扰， 混淆了 rsfMRI——提出了建模和减少这些影响的目标——或者引入了一种新的方法 研究具身大脑的技术——提出了利用这些效应的补充目标。 我们将追求三个目标： 1. 估计并减少胃节律缓慢对既定胃节律的影响 2. 证明控制胃部状态（空腹与进食）是否可以减少胃的影响。 胃节律对已建立的 rsfMRI 指标的影响 3. 描述胃节律和状态对胃节律的影响。 胃网络和其他大脑区域将解释由基础胃节律驱动的大脑活动。 通过允许 迄今为止无法解释的变异性的建模有可能改善统计。 通过减少会话间和受试者间差异来表征胃节律的影响。 大脑的状态将产生胃/大脑相互作用的新测量方法，这可能会导致新的研究 饮食失调，范围从厌食到肥胖。