TESLA MRI SCANNER: NEURAL DISORDERS

特斯拉 MRI 扫描仪：神经疾病

• 批准号: 7335115
• 负责人: JAMES J. PEKAR
• 金额: $ 30万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7335115
• 关键词: brain; head; mammary gland

This subproject is one of many research subprojects utilizing the resources provided by a Shared Instrumentation Grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the grant, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): We propose to acquire a 16-channel broadband digital radio-frequency (RF) system upgrade for the 3 Tesla MRI system at the P.M. Kirby Research Center at the Kennedy Krieger Institute. This upgrade includes multi-element receiver coils for brain, head and neck, infant brain, and breast. Our 3 T scanner currently has only six RF channels, which are not sufficient to use these new multi-element receiver coils. No 16-channel 3 T scanner is presently available at our institutions. Investigators at the Kennedy Krieger Institute, Johns Hopkins University, and the University of Maryland presently have 15 NIH-funded projects and 1 NSF-funded project with several aims that will strongly benefit from the improved technical capabilities offered by this upgrade. These investigators presently use the 3 T system in the F.M. Kirby Research Center for structural and functional MRI, quantitative physiological MRI, MR spectroscopy (MRS) and spectroscopic imaging (MRSI), and diffusion tensor imaging (DTI). The proposed upgrade will provide the following specific benefits for current users: 1) Compared to the 6-channel system currently in use, the 16-element head coil increases 1H MR sensitivity at the cortex by at least 27%, and reduces the noise-amplification penalty for high-rate SENSE by 77%. These primary advantages can be used to: a) better detect small fMRI signal changes; b) increase spatial resolution; c) increase temporal resolution (yield more data points per time in dynamic studies); d) reduce scan times (shorten scans); e) reduce spatial distortions. 2) The 16-element neuro-vascular coil allows integrated head and neck exams (i.e., combined scanning of the cervical spine and brain in single acquisitions), providing significant time savings. 3) The 8-element knee coil ("infant head coil") increases 1H MR sensitivity in infant (0-2 years old) cortex by ca. 40% (compared to the adult head coil now used). 4) The 7-element breast coil will allow breast MR studies to move from 1.5 T to 3 T, approximately doubling SNR. Furthermore, the 7-element coil will yield roughly an additional 20% SNR increase compared with 4- element coils, such as that now used at 1.5 T. The increases in sensitivity yielded by these multi-element coils are highly significant. For instance, the 27% increase in cortical sensitivity from the 16-element head coil compares to an increase in field strength to about 4 T, and would permit at least a 38% reduction in acquisition time, crucial for the special populations of children (e.g., autism; ADHD) studied at Kennedy Krieger Institute. The 3 T 16-channel digital RF upgrade is essential for continued high-quality state-of-the-art research at our institutions and for the national facilities provided by our Research Resource.

该副本是利用NIH/NCRR资助的共享仪器赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是赠款，这不一定是调查人员的机构。描述（由申请人提供）：我们建议在下午3点收购3个特斯拉MRI系统的16通道宽带数字射频（RF）系统升级。肯尼迪·克里格研究所（Kennedy Krieger Institute）的柯比研究中心。该升级包括用于大脑，头颈部，婴儿大脑和乳房的多元素接收器线圈。我们的3 T扫描仪目前只有6个RF频道，这不足以使用这些新的多元素接收器线圈。目前，我们机构目前可以使用16通道3 T扫描仪。 肯尼迪·克里格学院（Kennedy Krieger Institute），约翰·霍普金斯大学（Johns Hopkins University）和马里兰大学（University of Maryland）的调查人员目前拥有15个NIH资助的项目和1个NSF资助的项目，其目标将从此升级提供的改进的技术能力中受益匪浅。这些调查人员目前使用F.M.中的3 T系统。柯比结构和功能性MRI，定量生理MRI，MR光谱学（MRS）和光谱成像（MRSI）（MRSI）以及扩散张量成像（DTI）的研究中心。 拟议的升级将为当前用户提供以下特定的好处：1）与当前使用的6通道系统相比，16个元素的头线线圈在皮质上提高1H MR敏感性至少至少27％，并减少了高率Sense的降噪惩罚。这些主要优点可用于：a）更好地检测小型fMRI信号变化； b）增加空间分辨率； c）增加时间分辨率（在动态研究中每次获得更多数据点）； d）减少扫描时间（缩短扫描）； e）减少空间扭曲。 2）16个元素神经血管线圈允许整合的头颈检查（即，在单个采集中对颈椎和大脑的组合扫描），可节省大量时间。 3）8元素的膝盖线圈（“婴儿头盘管”）通过Ca提高婴儿（0-2岁）皮层的1H MR敏感性。 40％（与现在使用的成年头线圈相比）。 4）7个元素的乳房线圈将使乳房MR研究从1.5 t移动到3 t，大约增加了SNR。此外，与4个元素线圈相比，7个元素线圈将大约增加20％的SNR，例如现在在1.5 t时使用的。例如，从16个元素头线线圈提高的皮质灵敏度增加了27％，与野外强度增加到约4 t相比，其获取时间至少降低了38％，对于在肯尼迪·克里格格研究所（Kennedy Krieger Institute）研究的特殊儿童（例如自闭症； ADHD）至关重要。 3 T 16通道数字RF升级对于我们机构的持续高质量最先进的研究以及我们的研究资源提供的国家设施至关重要。