Center for Mesoscale Mapping

中尺度测绘中心

• 批准号: 10038177
• 负责人: BRUCE R ROSEN
• 金额: $ 173.15万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10038177
• 关键词: 3-Dimensional; Acceleration; Address; Alzheimer' s Disease; Anatomic Models; Basic Science; Biological; Brain; Brain Stem; Cell Nucleus; Cerebral Palsy; Communities; Computer Models; Computer software; Consensus; Data; Data Set; Development; Devices; Diffusion; Disease; Educational process of instructing; Educational workshop; Electroencephalography; Electromagnetics; Electrophysiology (science); Epilepsy; Evaluation; Event; Fiber; Frequencies; Functional Magnetic Resonance Imaging; Generations; Goals; Histologic; Human; Image; Investigation; Link; Machine Learning; Magnetic Resonance Imaging; Maps; Measures; Mental Depression; Mental disorders; Microscopic; Mind; Modeling; Molecular; Morphologic artifacts; Motion; Multiple Sclerosis; Neurons; Neurosciences; Online Systems; Performance; Peripheral Nerve Stimulation; Property; Publications; Research Personnel; Resolution; Resources; Respiration; Scanning; Services; Signal Transduction; Sleep Disorders; Slice; Space Models; Spatial Distribution; Structure; Surface; System; Techniques; Technology; Time; Training; Training Programs; Transcranial magnetic stimulation; Visualization; Work; base; cognitive neuroscience; data space; deep learning; design; electric field; frontier; human disease; human imaging; improved; in vivo; industry partner; instrumentation; machine learning algorithm; nervous system disorder; neuroimaging; novel; open source; post-doctoral training; pre-doctoral; reconstruction; relating to nervous system; response; spatiotemporal; tool; tool development; translational neuroscience; usability; white matter

Overview of the Proposed Resource – Abstract The goal of the Center for Mesoscale Mapping is to drive the convergence of microscopic- and macroscopic- scale evaluation of brain structure and function for human translational neuroscience, by developing and applying tools to study the spatial distribution and temporal orchestration of mesoscopic events in the human brain. Our Collaborators will, through a dynamic “push-pull” relationship, provide unique problems which drive the development of these tools, and in return guide us in the design and optimization of our toolbox for practical use in a variety of normal and disease settings. While there is still no formal consensus on the definition of mesoscopic within the neuroscience community, we take as our guide the spatial and temporal scales at which local groups of neurons act in coherent fashion – in the cortex, this includes the spatial scale of columns and laminar structures (between ~0.1-1 mm), while in deeper structures includes the myriad of deep brain and brainstem nuclei. Preliminary data from our own center, and of course others throughout the world, now support the notion that we are on the threshold of being able to map, measure and perturb the human brain at these scales, and do so comprehensively across wide swaths of the human brain. Temporally too, recent advances suggest a convergence between temporal scales addressable with tools like fMRI, which can now investigate delta frequency coherent phenomena, and advanced electromagnetic tools to measure and perturb coherent electrophysiological activity at higher frequencies still. With this convergence in mind, the tools we proposed to develop within the TRDs of the CMM will provide our Collaborative and Service User community with the important “missing links” between the advances in human cognitive neuroscience at the “system level,” and the enormous strides in cellular level circuit functional characterization. Our Collaborators will bring their own unique challenges to help us define and further refine these tools, offering problems requiring distinct measures of human brain structural and functional properties in a variety of normal and disease settings. Our Service Users will utilize our tools to better understand human neural systems, and particularly human disease states from multiple sclerosis to Alzheimer’s, to depression and epilepsy. Finally, our Center will seek to disseminate these tools, through open-source software and hardware designs, industrial partnerships and “hands-on” teaching courses for hardware, and to train a new generation of human neuroscientists in the use of our advanced tools to explore the human brain at this next frontier.

提议的资源概述 - 摘要 中尺度映射中心的目的是驱动显微镜和宏观的收敛。 通过开发和应用人类翻译神经科学的大脑结构和功能的比例评估 研究人脑介绍事件的空间分布和临时编排的工具。我们的 合作者将通过动态的“推力”关系，提供独特的问题，以推动 这些工具的开发，作为回报，我们指导了我们的工具箱的设计和优化 在各种正常和疾病环境中。虽然在定义上仍然没有正式的共识 在神经科学社区中的介观，我们将其作为指导的空间和临时尺度。 局部神经元群体以连贯的方式起作用 - 在皮层中，其中包括柱子的空间尺度和 层状结构（介于〜0.1-1 mm之间），而在更深的结构中包括无数的深脑和 脑干核。来自我们自己中心的初步数据，当然还有世界各地的其他数据，现在支持 我们正处于能够绘制，测量和扰动人类大脑的阈值的概念 鳞片，并在人类大脑的宽大范围内进行全面的做法。在时间上，最近的进步也 建议使用诸如fMRI之类的工具来解决临时量表之间的融合，该工具现在可以调查 增量频率相干现象和高级电磁工具，用于测量和扰动相干 在较高频率下的电生理活性仍在考虑到这种融合，我们提出的工具 在CMM的TRD中开发将为我们的协作和服务用户社区提供 人类认知神经科学在“系统层面”的进步与 细胞水平电路功能表征的巨大步伐。我们的合作者将带来自己独特的 帮助我们定义和进一步完善这些工具的挑战，提供了需要不同措施的问题 在多种正常和疾病环境中的人脑结构和功能特性。我们的服务用户 将利用我们的工具更好地了解人类神经系统，尤其是人类疾病状态 多发性硬化症患阿尔茨海默氏症，抑郁和癫痫。最后，我们的中心将寻求传播这些 工具，通过开源软件和硬件设计，工业合作伙伴关系和“动手”教学 硬件课程，并培训新一代人的神经科学家使用我们的先进工具 在下一个边界探索人的大脑。