Core B: Biostatistics / Bioinformatics

核心B：生物统计学/生物信息学

• 批准号: 10006077
• 负责人: Sumithra Jay Mandrekar
• 金额: $ 8.63万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-10 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10006077
• 关键词: Archives; Area; Basic Science; Bioinformatics; Biometry; Blood; Cholangiocarcinoma; Clinic; Clinical; Clinical Sciences; Clinical Trials; Collaborations; Communities; Computational Biology; Computer software; Consultations; Correlative Study; Country; Data; Data Analyses; Data Analytics; Data Collection; Data Management Resources; Databases; Development; Ensure; Funding; Future; Gene Mutation; Genomics; Goals; Hepatobiliary; Immunologics; Industry; Informatics; Information Management; Infrastructure; Institution; Manuscripts; Mayo Clinic Cancer Center; Measurement; Medidata; Mentors; Methods; Molecular; Mutation; Nature; Normal tissue morphology; Pathology; Pathway Analysis; Patients; Pilot Projects; Preparation; Primary carcinoma of the liver cells; Procedures; Process; Program Research Project Grants; Quality Control; Records; Registries; Research; Research Design; Research Personnel; Research Project Grants; Resource Sharing; Resources; Sampling; Sequence Alignment; Services; System; Testing; The Cancer Genome Atlas; Time; Tissues; Variant; Work; adverse event monitoring; anticancer research; bioinformatics pipeline; cancer therapy; career; central database; cost effective; data archive; data management; data quality; data reuse; design; follow-up; genomic data; health science research; hepatobiliary cancer; innovation; member; programs; quality assurance; research study; statistics; tool; translational study; tumor

CORE B BIOSTATISTICS AND BIOINFORMATICS – PROJECT SUMMARY The Biostatistics and Bioinformatics Core (BBC) provides statistical, and bioinformatics, and computational biology collaboration and data management support for each of the Hepatobiliary Cancer (HBC) SPORE projects, developmental research and career enhancement projects, pilot projects and the other cores. The BBC has been active in preparing the statistical plan for each of the four projects in this application related to study design, analysis, and bioinformatics needs. The BBC builds upon the innovative and time-tested procedures and systems developed by Mayo Clinic, one of the largest statistical groups in the country whose members have collaborated on more than 13,000 clinical and basic science research studies since 1966. In the upcoming funding period, the Specific Aims of the BBC are as follows: Aim 1. Provide statistical and bioinformatics collaboration for each of the HBC SPORE projects, the developmental research program projects, the career enhancement program projects and the cores. We will provide statistical and bioinformatics support across different fields, including clinical trials, basic sciences including translational and immunologic correlative studies, sequencing and mutation discovery, expression analysis and genomics, and information management. Aim 2. Provide management and integration of existing and newly collected data through consistent and compatible data handling. Areas of support will include database development, data forms development and processing, data collection and entry, data archiving, quality control, and management of information relating to gene mutation identification. All of the clinical trials proposed in this application will take advantage of the extensive infrastructure available to trials through the Mayo Clinic Cancer Center (MCCC), With multiple types of molecular and genomic measurements already processed through the Cancer Genome Atlas (TCGA), we will develop a centralized database to organize processed level-3 molecular and genomic data, and connect these data with a registry database for detailed clinical records, follow-up information, and availability of tissue/blood biospecimens. Aim 3. Provide support to the Biospecimen and Pathology Core in providing biospecimen resources to the research community. Through this support we aim to provide efficient and prompt access to the biospecimen resources for HBC investigators. Biospecimen resources will also be connected to data management and centralization system described in Aim 2 to facilitate collaboration and data reuse across the HBC SPORE.

核心 B 生物统计学和生物信息学 – 项目摘要 生物统计学和生物信息学核心（BBC）提供统计、生物信息学和计算 为每个肝胆癌 (HBC) SPORE 提供生物学协作和数据管理支持 项目、发展研究和职业提升项目、试点项目和其他核心项目。 BBC 一直积极为本申请中涉及的四个项目准备统计计划 研究设计、分析和生物信息学需求是 BBC 建立在创新和经过时间考验的基础上的。 梅奥诊所 (Mayo Clinic) 开发的程序和系统，该诊所是美国最大的统计集团之一， 自 1966 年以来，成员已合作开展了 13,000 多项临床和基础科学研究。 在即将到来的资助期内，BBC的具体目标如下： 目标 1. 为每个 HBC SPORE 项目、 发展研究计划项目、职业提升计划项目和核心我们将。 提供不同领域的统计和生物信息学支持，包括临床试验、基础科学 包括翻译和免疫学相关研究、测序和突变发现、表达 分析和基因组学以及信息管理。 目标 2. 通过一致和一致的方式对现有数据和新收集的数据进行管理和集成 支持的领域包括数据库开发、数据表单开发和 处理、数据收集和输入、数据归档、质量控制以及相关信息的管理 本申请中提出的所有临床试验都将利用基因突变鉴定。 梅奥诊所癌症中心 (MCCC) 可提供用于试验的广泛基础设施，具有多种类型 通过癌症基因组图谱 (TCGA) 处理的分子和基因组测量数据，我们 将开发一个集中数据库来组织处理后的三级分子和基因组数据，并连接 这些数据包含一个注册数据库，用于详细的临床记录、随访信息和可用性 组织/血液生物样本。 目标 3. 为生物样本和病理学核心提供支持，为生物样本资源提供支持 通过这种支持，我们的目标是为研究界提供高效、及时的生物样本获取途径。 HBC 研究人员的资源也将与数据管理和 目标 2 中描述的集中化系统旨在促进 HBC SPORE 内的协作和数据重用。