SCREENING FOR LUNG CANCER IN THE HIV PATIENT

HIV 患者的肺癌筛查

• 批准号: 7604658
• 负责人: MALCOLM V BROCK
• 金额: $ 6.82万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604658
• 关键词: Cancer Patient; Caring; Clinic; Clinical; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Funding; Goals; Grant; HIV; HIV Seropositivity; Institution; Life; Malignant neoplasm of lung; Patients; Range; Rate; Reproduction spores; Research; Research Personnel; Resources; Risk Factors; Source; United States National Institutes of Health; X-Ray Computed Tomography; antiretroviral therapy; cohort; lung cancer screening; mortality

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV patients are living longer due to advanced antiretroviral therapy. Cases of lung cancer in these patients are increasing with an excessive mortality rate. We determined to examine a wide range of clinical and pathological variables to elucidate the risk factors most critical to survival, and to determine whether or not our longitudinal clinical care of our HIV-positive patients needed to change given the excessive mortality of HIV-infected patients with lung cancer. The Lung Cancer SPORE and HIV clinic databses have generated 87 HIV-positive lung cancer patients from 1989-2003. This is the largest single institution cohort of such patients. Our long-term goal is to use CT scans to diagnose lung cancer earlier in the HIV-infected patient so that early therapy can be initiated with possible long-term survival.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 由于先进的抗逆转录病毒治疗，艾滋病毒患者的寿命更长。 这些患者的肺癌病例不断增加，死亡率极高。 我们决定检查广泛的临床和病理变量，以阐明对生存最关键的风险因素，并确定鉴于艾滋病毒感染者死亡率过高，我们对艾滋病毒阳性患者的纵向临床护理是否需要改变患有肺癌。 1989 年至 2003 年间，肺癌 SPORE 和 HIV 临床数据库已收集了 87 名 HIV 阳性肺癌患者。 这是最大的单一机构此类患者队列。 我们的长期目标是利用 CT 扫描早期诊断 HIV 感染者的肺癌，以便尽早开始治疗，从而可能实现长期生存。