Screening for Lung Cancer in the HIV Patient
HIV 患者的肺癌筛查
基本信息
- 批准号:7115021
- 负责人:
- 金额:$ 14.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-09-01 至 2008-08-31
- 项目状态:已结题
- 来源:
- 关键词:DNA methylationHIV infectionsbioimaging /biomedical imagingcancer registry /resourcecancer riskclinical researchcomputed axial tomographyearly diagnosisgene environment interactionhigh risk behavior /lifestylehuman subjectlung imaging /visualization /scanninglung neoplasmsmass screeningneoplasm /cancer classification /stagingneoplasm /cancer diagnosisneoplasm /cancer geneticspatient oriented researchserumsmokingsputumtissuestobacco abuse
项目摘要
DESCRIPTION (provided by applicant): Preliminary data from HIV-seropositive patients at Johns Hopkins demonstrate a high rate of death from lung cancer. We derived 87 cases of HIV-seropositive patients with lung cancer who had been treated at the institution. Almost all patients were young (median age 46 years), African-American males from inner city Baltimore with a strong history of cigarette smoking. The prevalence of smoking was 97%, with 89% being current smokers. Despite patients being carefully followed for their HIV disease, only 4.6% of the HIV-positive lung cancer patients initially presented with stage 1 disease, and only 11 patients (13%) were able to undergo surgery. Over the past 5 years, six large-scale computed tomography (CT) lung cancer screening trials of 18,387 patients at high risk for lung cancer have been published. Of 140 lung cancers detected, 79% (110/140) had stage 1 disease. This contrasts with 24% of patients presenting with stage 1 lung cancer patients without CT screening. This suggests that CT screening is sensitive in detecting small, early stage lung cancer. We hypothesize that CT screening of heavy HIV-seropositive smokers will detect a higher proportion of stage 1 lung cancers than are currently being detected. This project is a prospective cohort study that will enroll 200 HIV-seropositive smokers who have current or previous smoking history of at least 20 pack years. We anticipate 18 lung cancers in the first year alone. Specific aim 1 addresses if differences in stage distribution of HIV-positive patients at lung cancer diagnosis can be determined between those HIV-positive heavy smokers who are screened by spiral CT and historical controls. Our second specific aim focuses on the establishment of a specimen bank of serum, sputum, and tissue from these screened HIV-positive smokers. Our third specific aim is to use epigenetic analysis of sera and sputa collected in Specific Aim 2 as a complementary approach to low dose helical CT in order to discriminate radiologically indeterminate nodules as either molecularly positive or negative.
描述(由申请人提供):约翰·霍普金斯大学 HIV 血清阳性患者的初步数据表明肺癌死亡率很高。我们收集了 87 例在该机构接受过治疗的 HIV 血清阳性肺癌患者。几乎所有患者都是年轻的(中位年龄 46 岁)、来自巴尔的摩内城区的非裔美国男性,有很强的吸烟史。吸烟率为 97%,其中 89% 为当前吸烟者。尽管对患者的 HIV 疾病进行了仔细随访,但只有 4.6% 的 HIV 阳性肺癌患者最初出现 1 期疾病,并且只有 11 名患者 (13%) 能够接受手术。在过去的 5 年里,已经发表了 6 项大规模计算机断层扫描 (CT) 肺癌筛查试验,涉及 18,387 名肺癌高危患者。在检测到的 140 例肺癌中,79% (110/140) 患有 1 期疾病。相比之下,24% 的 1 期肺癌患者未经 CT 筛查。这表明 CT 筛查对于检测小型早期肺癌非常敏感。我们假设,对 HIV 血清阳性吸烟者进行 CT 筛查将检测出比目前检测到的更高比例的 1 期肺癌。该项目是一项前瞻性队列研究,将招募 200 名 HIV 血清阳性吸烟者,他们目前或既往有至少 20 包年的吸烟史。我们预计仅第一年就会出现 18 例肺癌。具体目标 1 解决了是否可以确定通过螺旋 CT 筛查的 HIV 阳性重度吸烟者和历史对照之间 HIV 阳性患者在肺癌诊断时分期分布的差异。我们的第二个具体目标集中于建立这些筛查出的艾滋病毒阳性吸烟者的血清、痰液和组织样本库。我们的第三个具体目标是使用特定目标 2 中收集的血清和痰的表观遗传学分析作为低剂量螺旋 CT 的补充方法,以区分放射学不确定的结节为分子阳性或阴性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
MALCOLM V BROCK其他文献
MALCOLM V BROCK的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('MALCOLM V BROCK', 18)}}的其他基金
Sodium channel mutations as a possible cause for primary dysautonomia
钠通道突变可能是原发性自主神经功能障碍的原因
- 批准号:
10586393 - 财政年份:2023
- 资助金额:
$ 14.01万 - 项目类别:
Developing a CLIA compliant LDT for detecting plasma piR-Ls/pfeRNAs to distinguish benign and malignant lung nodules
开发符合 CLIA 标准的 LDT,用于检测血浆 piR-Ls/pfeRNA,以区分良性和恶性肺结节
- 批准号:
9908056 - 财政年份:2019
- 资助金额:
$ 14.01万 - 项目类别:
相似国自然基金
艾滋病毒感染后疾病进展和治疗的动力学模型与研究
- 批准号:10971163
- 批准年份:2009
- 资助金额:26.0 万元
- 项目类别:面上项目
用细菌传递RNA干扰经肠道黏膜免疫系统治疗艾滋病毒感染
- 批准号:30972624
- 批准年份:2009
- 资助金额:30.0 万元
- 项目类别:面上项目
艾滋病毒感染病者口腔疣状肿块的细胞生物学特性
- 批准号:30660199
- 批准年份:2006
- 资助金额:20.0 万元
- 项目类别:地区科学基金项目
HIV-1 tat 蛋白及其相互作用的细胞因子功能性研究
- 批准号:30570069
- 批准年份:2005
- 资助金额:8.0 万元
- 项目类别:面上项目
相似海外基金
Purchase of a large format CCD camera for 3-D EM
购买用于 3-D EM 的大幅面 CCD 相机
- 批准号:
6877307 - 财政年份:2005
- 资助金额:
$ 14.01万 - 项目类别:
SPECTROSCOPIC SPECIATION OF SULFUR IN LIVING MAMMALIAN CELLS: HIV & APOPTOSIS
活哺乳动物细胞中硫的光谱形态:HIV
- 批准号:
7180413 - 财政年份:2005
- 资助金额:
$ 14.01万 - 项目类别:
Automated monitoring of MRI abnormalities in HIV/AIDS
自动监测 HIV/AIDS MRI 异常
- 批准号:
6941315 - 财政年份:2004
- 资助金额:
$ 14.01万 - 项目类别: