ROLE OF SLEEP DURATION IN METABOLIC AGING

睡眠时间在代谢衰老中的作用

• 批准号: 7604750
• 负责人: Plamen Penev
• 金额: $ 3.71万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604750
• 关键词: Adipose tissue; Adult; Aging; Biological Markers; Body fat; Computer Retrieval of Information on Scientific Projects Database; Daily; Deposition; Development; Diet; Eating; Funding; Grant; Hunger; Institution; Metabolic; Metabolic Marker; Metabolic syndrome; Protocols documentation; Recurrence; Research; Research Personnel; Research Project Grants; Resources; Risk; Role; Satiation; Sleep; Source; Testing; United States National Institutes of Health; energy balance; improved; middle age

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research project includes two experimental protocols aimed at examining the effects of varying sleep duration on daily energy balance, hunger, satiety, food intake, body fat deposition, and key markers of cardiometabolic risk in middle-aged adults at risk for accelerated metabolic aging. The specific aims are: 1). To test the hypothesis that recurrent sleep curtailment will result in excessive food intake, increased deposition of body fat, and development of metabolic syndrome biomarkers; 2). To test the hypothesis that recurrent sleep curtailment will compromise the efficacy of a low-calorie diet and result in decreased loss of adipose tissue; 3). To test the hypothesis that sleep extension will increase the efficacy of a low-calorie diet and result in improved metabolic markers and adipose tissue loss.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该研究项目包括两个实验方案，旨在研究不同睡眠时间对每日能量平衡、饥饿、饱腹感、食物摄入、身体脂肪沉积以及有加速代谢衰老风险的中年人心脏代谢风险关键标志物的影响。具体目标是：1）．检验反复睡眠不足会导致食物摄入过多、体内脂肪沉积增加以及代谢综合征生物标志物形成的假设； 2）。检验以下假设：反复减少睡眠会损害低热量饮食的功效并导致脂肪组织损失减少； 3）。检验延长睡眠时间将提高低热量饮食的功效并改善代谢指标和减少脂肪组织的假设。