Genome Technologies and Bioinformatics

基因组技术和生物信息学

基本信息

批准号：
10006838
负责人：
JEFFREY P. BOND
金额：
$ 23.38万
依托单位：
UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-05 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10006838
关键词：
Applications Grants Archives Back Bioinformatics Biomedical Research Centers of Research Excellence Characteristics Clostridium difficile Collaborations Communicable Diseases Communities Core Facility DNA sequencing Data Data Analyses Data Collection Databases Development Documentation Education Educational workshop Epigenetic Process Equipment Experimental Designs Faculty Fee-for-Service Plans Gene Chips Gene Expression Genes Genome Genomics Goals Histones Human Resources Immunobiology Immunology Infrastructure Institution Laboratories Leadership Libraries Linear Models Manuscripts Massive Parallel Sequencing Measurement Medicine Methodology Methylation Modification Multivariate Analysis Oligonucleotide Microarrays Persons Phase Process Pseudomonas aeruginosa Publications RNA Research Research Personnel Review Committee Services Stream Structure Surveys Techniques Technology TimeLine Universities Variant Vermont Vocabulary base college cost data acquisition data submission deep sequencing design exome exome sequencing experience experimental study falls genome sequencing genome-wide genomic data instrumentation member microbial pathogenic bacteria programs reference genome sequencing platform statistics success transcriptome sequencing

项目摘要

SUMMARY for the Genome Technologies and Bioinformatics Core The uniformly recognized significance of genomics and bioinformatics for the biomedical research community is also reflected in needs expressed by VCIID faculty members. This core provides support in all aspects of genomics, from the design stage, through data acquisition/quality assessment, and finally extensive bioinformatics support. The core uses an Affymetrix GeneChip and Illumina HiSeq technologies for oligonucleotide arrays and massively parallel sequencing, respectively. It is currently supporting projects for 11 COBRE faculty members, and has performed genomics data collection and analysis for 86 active COBRE projects. Preliminary discussions are underway for new projects with 16 additional COBRE faculty members. Accomplishments from Phases I and II include support for 28 publications, and addition of massively parallel sequencing services. Based on over 40 person-years of experience among the Core Directors leading core facilities, they identified eight essential characteristics needed for the Core: qualified and experienced staff, state-of-the-art equipment, education, responsiveness, process, experiment design, quality assessment, and sustainability. The Phase III COBRE objectives of the Genome Technologies and Bioinformatics Core satisfy these essential characteristics. Specific Aim 1 will provide state-of-the-art equipment, cutting-edge techniques, and experienced personnel to enhance the research of the VCIID-COBRE. Specific Aim 2 will provide a wide array of services to VCIID-COBRE faculty to facilitate their research. We will meet this goal by applying our standard process to projects that includes oversight by a project manager, experiment design, defined vocabulary, quality assessment, archival storage, and documentation. We have surveyed the user base, and are prepared to offer efficient and effective service to support VCIID collaborations. Specific Aim 3 will continue our Phase II plan for sustainability that includes a greatly expanded user base, both at UVM as well as at several other campuses. We have developed a progressive fee-for-service structure, and are highly responsive to the need for constant adaptation to changes in research needs. We have received strong commitments for sustained support from the institution for at least five years beyond Phase III, and we will add revenue streams based on VCIID collaborations that will sustain our core beyond Phase III. Our aims and objectives reflect both the eight essential characteristics identified by our leadership and the VCIID needs identified by a survey of the VCIID. These aims will facilitate the transition of the Core into a fully self-sustainable facility capable of continuing to support state-of-the-art research.

基因组技术和生物信息学核心摘要基因组学和生物信息学对生物医学研究界的普遍认可的重要性 VCIID 教员表达的需求也反映了这一点。这个核心提供了各个方面的支持基因组学，从设计阶段，通过数据采集/质量评估，最后广泛生物信息学支持。核心使用 Affymetrix GeneChip 和 Illumina HiSeq 技术分别是寡核苷酸阵列和大规模并行测序。目前正在支持的项目有 11 名 COBRE 教员，并为 86 名活跃 COBRE 进行了基因组学数据收集和分析项目。目前正在与另外 16 名 COBRE 教员就新项目进行初步讨论。第一阶段和第二阶段的成就包括对 28 种出版物的支持，以及添加大规模并行测序服务。根据核心董事领导核心设施超过 40 人年的经验，他们确定核心所需的八个基本特征：合格且经验丰富的员工、最先进的设备、教育、响应能力、流程、实验设计、质量评估和可持续性。第三期基因组技术和生物信息学核心的 COBRE 目标满足了这些基本要求特征。具体目标 1 将提供最先进的设备、尖端技术和经验丰富的人员来加强 VCIID-COBRE 的研究。具体目标 2 将提供广泛的为 VCIID-COBRE 教师提供一系列服务，以促进他们的研究。我们将通过应用我们的项目的标准流程，包括项目经理的监督、实验设计、定义词汇、质量评估、档案存储和文档。我们调查了用户群，并且准备提供高效、有效的服务来支持 VCIID 合作。具体目标 3 将继续我们的第二阶段可持续发展计划，其中包括大幅扩大 UVM 的用户群与其他几个校区一样。我们制定了累进的服务收费结构，并且高度重视响应不断适应研究需求变化的需要。我们收到了强有力的承诺在第三阶段之后至少五年内获得该机构的持续支持，我们将添加基于 VCIID 合作的收入流将在第三阶段之后维持我们的核心业务。我们的宗旨和目标反映了我们的领导层和我们的领导层确定的八个基本特征通过 VCIID 调查确定的 VCIID 需求。这些目标将促进核心转变为全面的自我维持的设施能够继续支持最先进的研究。