Novel Strategies for Self-Healing Dental Materials

自修复牙科材料的新策略

• 批准号: 10006815
• 负责人: Ana Paula Piovezan Fugolin
• 金额: $ 10.87万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-04 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10006815
• 关键词: 3D Print; Acrylamides; Agitation; Amides; Area; Bite Force; Chemistry; Clinical; Composite Resins; Covalent Interaction; Data; Dental Materials; Development; Diffusion; Dimensions; Emulsions; Encapsulated; Esters; Esthetics; Evaluation; Face; Failure; Filler; Foundations; Fracture; Future; Goals; Growth; High Pressure Liquid Chromatography; Kinetics; Laboratories; Lead; Life; Longevity; Mastication; Mentors; Methacrylates; Methods; Microcapsules drug delivery system; Microencapsulations; Modification; Phase; Physiological; Process; Production; Property; Prosthodontic specialty; Prunella vulgaris; Reaction; Reproducibility; Research; Research Personnel; Resistance; Resources; Shapes; Solid; Spectrum Analysis; Standardization; Stress; Structure; Surface; System; Techniques; Technology; Temperature; Testing; Training; Translations; Viscosity; Walkers; base; capsule; career; composite restoration; design; healing; improved; innovation; mechanical properties; monomer; novel; novel strategies; oral condition; polymerization; polymerization stress; premature; prevent; repaired; restoration; restorative composite; side effect; skills; success; thermal stress

PROJECT SUMMARY/ABSTRACT Resin composite restoration failure is strongly associated to internal microcracks caused by the masticatory forces. A promising strategy to overcome this shortcoming lies is the addition of healing microcapsules in the organic matrix. These capsules, when reached by the crack, are broken and release the healing agent, inhibiting its propagation. However, there are several critical gaps and crucial improvements to make this approach suitable and commercially viable. Our long-term goals are to introduce optimized healing agents, minimize the side effects of addition of the capsules, via shell wall functionalization, and validate advanced method for encapsulation. Previous studies revealed that low viscosity amides are capable of modulating the polymerization reaction, and more tough and degradation-resistant than methacrylates, so these compounds are going to be used as alternative healing agents. In addition, thiourethane surface functionalization has been shown to be an efficient method to increase fracture toughness and reduce polymerization stress, so we propose to functionalize the capsule surface with this compound – the methods for functionalization were developed in our laboratory, which increases the chance of success. Finally, we will aim at overcoming the main issues involved in the double-emulsion method, such as poor size control of the capsules and high sensitivity of the method, by utilizing coaxial electrohydrodynamic atomization (CEHDA) technique for the encapsulation process. In summary, the following Specific Aims are proposed: (1) To introduce amides as healing agents, (2) To functionalize the microcapsule’s surface with thiourethane oligomers, and (3) To improve encapsulation process with advanced technology. Capsules will be characterized by SEM, HPLC, and Mid-IR spectroscopy. Self-healing composites will be tested for: kinetics, DMA, and mechanical properties under simulate oral conditions, and finally, the healing process analyzed by Serial Block-Face SEM. The central hypothesis is that the tough healing agent, shell wall functionalization, and introduction of CEHDA method to produce capsules will significantly increase the potential and viability of self-healing dental materials. The skills and new techniques necessary to accomplish the research plan will be acquired from the mentoring team (Drs. Carmem Pfeifer, Jack Ferracane, Luiz Bertassoni, Mary Anne Melo, Sung Yi and Travis Walker), who have pioneering expertise in using the proposed methods and strategies. Complementary background will be gained from seminars, structured tutorials and courseworks. The combination of the new skills learned during the K99 mentored phase with my prior expertise in dental materials characterization, and the advanced clinical training in Prosthodontics will lay the foundation of my independent career, focused on smart dental materials. Additionally, this proposal will broadly impact the field by modifying and improving essential self-healing components and developing an alternative method for encapsulation process, making this approach a tangible resource for resin composites survival.

项目摘要/摘要 树脂复合恢复失败与咀嚼性引起的内部微裂纹密切相关 力量。克服这一缺点的一个有希望的策略是增加了愈合的微胶囊 有机矩阵。这些胶囊被裂缝伸到时，被损坏并释放治愈剂， 抑制其传播。但是，有几个关键的差距和关键的改进可以做到这一点 方法合适且在商业上可行。我们的长期目标是引入优化的治疗剂， 最小化胶囊添加的副作用，通过壳壁功能化，并验证高级 封装方法。先前的研究表明，低粘度酰胺能够调节 与甲基丙烯酸酯相比，聚合反应，更坚韧和抗降解，因此这些化合物 将被用作替代愈合剂。另外，硫代甲烷表面功能化具有 被证明是增加断裂韧性和减轻聚合应力的有效方法，因此 我们建议用这种化合物功能化胶囊表面 - 功能化的方法是 在我们的实验室中发展，这增加了成功的机会。最后，我们将旨在克服 双乳液方法中涉及的主要问题，例如胶囊的尺寸控制差和高 该方法的敏感性，利用同轴电水动力雾化（CEHDA）技术 封装过程。总而言之，提出了以下具体目的：（1）将酰胺引入为 治愈剂，（2）用硫烷低聚物来使微胶囊的表面和（3）到 通过先进技术改善封装过程。胶囊将以SEM，HPLC为特征 和IR光谱法。将测试自我修复复合材料：动力学，DMA和机械 在模拟口服条件下的特性，最后是通过串行区块分析的愈合过程 SEM。中心假设是坚韧的愈合剂，壳墙功能化和引入 CEHDA生产胶囊的方法将显着提高自我修复牙齿的潜力和生存能力 材料。完成研究计划所需的技能和新技术将从 指导团队（Carmem Pfeifer博士，Jack Ferracane，Luiz Bertassoni，Mary Anne Melo，Sung Yi和 特拉维斯·沃克（Travis Walker），他们在使用拟议的方法和策略方面具有开创性的专业知识。 互补的背景将从精神分裂，结构化教程和课程中获得。这 我先前的牙科专家在K99修补阶段学习的新技能的结合 材料表征和假体的高级临床培训将奠定我的基础 独立职业，专注于智能牙科材料。此外，该提议将广泛影响 通过修改和改善基本的自我修复组件并开发一种替代方法来领域 封装过程，使这种方法成为树脂组成生存的切实资源。