Chemically Precise Framework Materials as a Modular Platform Technology for Electroanalysis

化学精确的框架材料作为电分析的模块化平台技术

• 批准号: 10028638
• 负责人: Katherine Andrea Mirica
• 金额: $ 40.7万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10028638
• 关键词: 3-Dimensional; Ascorbic Acid; Bioreactors; Chemicals; Coupled; Detection; Development; Devices; Dopamine; Electrodes; Electronics; Engineering; Environment; Future; Glucose; Goals; Health; Healthcare; Homeostasis; In Situ; Inflammation; Label; Metabolism; Metals; Molecular; Monitor; Morphology; Nutrient; Organ failure; Patients; Performance; Physiological; Process; Quality Control; Quality of life; Reporting; Research; Serotonin; Surface; System; Technology; Time; Tissue Engineering; Transducers; Trauma; Uric Acid; Work; base; chemical stability; chemical synthesis; design; flexibility; improved; interdisciplinary approach; manufacturing process; nanoscale; neurochemistry; novel; patient oriented; portability; scaffold; self assembly; solid state; tissue support frame; wearable device

Engineered tissue holds tremendous promise for improving health and quality of life of patients suffering from trauma, illness, or organ failure. Realizing the full benefits in tissue engineering requires improved fundamental understanding of homeostasis, metabolism, inflammation, and nutrient transport in engineered tissue, coupled with reliable and integrated quality control during the manufacturing process. By virtue of being modular, portable, capable of operating in real-time environments, as well as being amenable to non-invasive and label-free formats, a chemical quality control based on electroanalysis offers one plausible solution to this challenge. However, current electroanalytical devices do not allow for selective in-situ continuous chemical monitoring and reporting of performance in engineered 3D tissue scaffolds within enclosed bioreactors. Enabling the study of chemical processes of engineered tissue requires radically new sensing materials with improved chemical sensitivity, selectivity, chemical stability capable of straightforward integration with 3D tissue scaffolds. The overarching goal of this research is to develop conductive metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) as multifunctional sensing materials with broad potential utility in electroanalysis. The proposed technological approach to chemical detection offers unprecedented ability to generate atomically-precise electronic materials and devices with chemically-tunable electroanalytical performance. This MIRA application leverages bottom-up synthesis and self-assembly to develop sensitive and selective non-enzymatic porous working electrodes for gasotransmitters (CO, NO, H2S), nutrients and metabolites (glucose and lactate), and neurochemicals (ascorbic acid, uric acid, dopamine, and serotonin). The research plan implements a multidisciplinary approach comprising chemical synthesis, spectroscopic characterization, device integration, and electroanalysis to achieve three hierarchical levels of chemical control in molecular engineering of framework materials for chemical detection: (1) Atomic-level control of host-guest interactions through solvothermal synthesis and self-assembly; (2) Nanoscale control through morphological tuning of surface electrocatalysis; (3) Epitaxial control of electrochemical interfaces within solid-state, porous, and flexible devices. Conceptual and technological advances emerging from this work will serve as a vehicle to develop the proposed materials into novel components of future electroanalytical devices with transformative potential in tissue engineering, biomedical analysis, and patient- centered mobile healthcare.

工程组织对于改善患者的健康和生活质量具有巨大的希望 遭受创伤、疾病或器官衰竭。实现组织工程的全部优势 需要更好地了解体内平衡、新陈代谢、炎症和 工程组织中的营养物质运输，加上可靠且综合的质量控制 制造过程。模块化、便携、实时操作 环境，以及适合非侵入性和无标签格式，一种化学品 基于电解分析的质量控制为这一挑战提供了一种可行的解决方案。然而， 当前的电分析设备不允许选择性原位连续化学监测 并报告封闭生物反应器内工程化 3D 组织支架的性能。 实现工程组织化学过程的研究需要全新的传感技术 具有改进的化学敏感性、选择性、化学稳定性的材料 与 3D 组织支架直接集成。 这项研究的总体目标是开发导电金属有机框架 （MOF）和共价有机骨架（COF）作为多功能传感材料，具有广泛的应用前景。 在电分析中的潜在用途。拟议的化学检测技术方法 提供了前所未有的能力来生成原子级精确的电子材料和设备 化学可调的电分析性能。此 MIRA 应用程序利用自下而上 合成和自组装以开发敏感和选择性的非酶促多孔工作 气体递质（CO、NO、H2S）、营养物和代谢物（葡萄糖和乳酸）的电极， 和神经化学物质（抗坏血酸、尿酸、多巴胺和血清素）。 该研究计划采用多学科方法，包括化学合成、 光谱表征、设备集成和电分析实现三个 骨架材料分子工程中化学控制的分级水平 化学检测：（1）通过溶剂热对主客体相互作用进行原子级控制 合成和自组装； (2)通过表面形态调控实现纳米级控制 电催化； (3) 固态、多孔和电化学界面的外延控制 灵活的设备。这项工作中出现的概念和技术进步将作为 将所提出的材料开发成未来电分析的新型组件的工具 在组织工程、生物医学分析和患者领域具有变革潜力的设备 以移动医疗为中心。