Chemically Precise Framework Materials as a Modular Platform Technology for Electroanalysis

化学精确的框架材料作为电分析的模块化平台技术

• 批准号: 10456863
• 负责人: Katherine Andrea Mirica
• 金额: $ 40.7万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10456863
• 关键词: 3-Dimensional; Ascorbic Acid; Bioreactors; Chemicals; Coupled; Detection; Development; Devices; Dopamine; Electrodes; Electronics; Engineering; Environment; Future; Glucose; Goals; Health; Healthcare; Homeostasis; In Situ; Inflammation; Label; Metabolism; Metals; Molecular; Monitor; Morphology; Nutrient; Organ failure; Patients; Performance; Physiological; Process; Quality Control; Quality of life; Reporting; Research; Serotonin; Surface; System; Technology; Time; Tissue Engineering; Transducers; Trauma; Uric Acid; Work; base; chemical stability; chemical synthesis; design; flexibility; improved; interdisciplinary approach; manufacturing process; nanoscale; neurochemistry; novel; patient oriented; portability; scaffold; self assembly; solid state; tissue support frame; wearable device

Engineered tissue holds tremendous promise for improving health and quality of life of patients suffering from trauma, illness, or organ failure. Realizing the full benefits in tissue engineering requires improved fundamental understanding of homeostasis, metabolism, inflammation, and nutrient transport in engineered tissue, coupled with reliable and integrated quality control during the manufacturing process. By virtue of being modular, portable, capable of operating in real-time environments, as well as being amenable to non-invasive and label-free formats, a chemical quality control based on electroanalysis offers one plausible solution to this challenge. However, current electroanalytical devices do not allow for selective in-situ continuous chemical monitoring and reporting of performance in engineered 3D tissue scaffolds within enclosed bioreactors. Enabling the study of chemical processes of engineered tissue requires radically new sensing materials with improved chemical sensitivity, selectivity, chemical stability capable of straightforward integration with 3D tissue scaffolds. The overarching goal of this research is to develop conductive metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) as multifunctional sensing materials with broad potential utility in electroanalysis. The proposed technological approach to chemical detection offers unprecedented ability to generate atomically-precise electronic materials and devices with chemically-tunable electroanalytical performance. This MIRA application leverages bottom-up synthesis and self-assembly to develop sensitive and selective non-enzymatic porous working electrodes for gasotransmitters (CO, NO, H2S), nutrients and metabolites (glucose and lactate), and neurochemicals (ascorbic acid, uric acid, dopamine, and serotonin). The research plan implements a multidisciplinary approach comprising chemical synthesis, spectroscopic characterization, device integration, and electroanalysis to achieve three hierarchical levels of chemical control in molecular engineering of framework materials for chemical detection: (1) Atomic-level control of host-guest interactions through solvothermal synthesis and self-assembly; (2) Nanoscale control through morphological tuning of surface electrocatalysis; (3) Epitaxial control of electrochemical interfaces within solid-state, porous, and flexible devices. Conceptual and technological advances emerging from this work will serve as a vehicle to develop the proposed materials into novel components of future electroanalytical devices with transformative potential in tissue engineering, biomedical analysis, and patient- centered mobile healthcare.

工程组织具有改善患者健康和生活质量的巨大希望 患有创伤，疾病或器官衰竭。意识到组织工程的全部好处 需要提高对体内平衡，代谢，炎症和 工程组织中的营养运输，并在 制造过程。通过模块化，便携，能够实时操作 环境以及不脱落和无标签格式的环境，一种化学 基于电分析的质量控制为这一挑战提供了一个合理的解决方案。然而， 当前的电分析设备不允许选择性的原位连续化学监测 并报告封闭的生物反应器中工程的3D组织支架中的性能。 启用工程组织化学过程的研究需要从根本上进行新的感应 具有提高化学敏感性，选择性，化学稳定性的材料能够 与3D组织支架的直接整合。 这项研究的总体目标是开发导电金属有机框架 （MOF）和共价有机框架（COF）作为具有宽阔的多功能感测材料 电分析中的潜在效用。提出的化学检测技术方法 提供前所未有的能力，以生成原子质的电子材料和设备 化学可调的电分析性能。此MIRA应用程序利用自下而上 合成和自组装以发展敏感和选择性的非酶多孔工作 燃气递质的电极（CO，NO，H2S），营养和代谢物（葡萄糖和乳酸）， 和神经化学物质（抗坏血酸，尿酸，多巴胺和5-羟色胺）。 该研究计划实现了包括化学合成的多学科方法， 光谱表征，设备整合和电分析以实现三个 框架材料分子工程中的化学控制水平 化学检测：（1）通过溶剂热的原子级控制宿主 - 阵线相互作用 合成和自组装； （2）通过表面形态调节纳米级控制 电催化； （3）对固态，多孔和多孔和 灵活的设备。这项工作从这项工作中得出的概念和技术进步将成为 将拟议材料开发成未来分析的新组件的车辆 在组织工程，生物医学分析和患者中具有变革潜力的设备 中心移动医疗保健。