Survey and Biospecimen Shared Resource

调查和生物样本共享资源

基本信息

批准号：
10024642
负责人：
QIUYIN CAI
金额：
$ 13.9万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-09-01 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10024642
关键词：
Achievement Adverse event Bioinformatics Biological Biological Assay Biological Markers Biostatistics Shared Resource Blood Cancer Center Cancer Center Support Grant Cancer Control Case-Control Studies Clinical Clinical Investigator Clinics and Hospitals Collection Communities Computer Assisted Consultations DNA Data Data Collection Data Science Diet Doctor of Philosophy Effectiveness Enrollment Ensure Environmental Exposure Epidemiologist Epidemiology Faculty Family Feces Genetic Genetic Markers Genotype Goals Health Health Services Research Immunohistochemistry Individual Industry Standard Interviewer Journals Laboratories Malignant Neoplasms Manuscripts Medical Records Mentorship Metagenomics Methods Mission Molecular Monitor NCI Center for Cancer Research Nature Oral cavity Outcome Study Participant Patient Recruitments Peer Review Pharmaceutical Preparations Population Population Research Population Sciences Population Study Postdoctoral Fellow Prevention Procedures Prospective cohort study Protocols documentation Publications Publishing Quality Control Quality of life RNA Recording of previous events Reproducibility Research Research Design Research Personnel Research Project Grants Resource Sharing Resources Retrieval Saliva Sampling Services Stains Students Surveys Symptoms System Telephone Interviews Tennessee Time Tissues Training United States Universities Urine Variant Work anticancer research biobank cancer epidemiology computerized data processing cost cost efficient deep sequencing design doctoral student epidemiology study experience genome sciences improved medical schools member metatranscriptomics microbiome research molecular marker nano-string new technology next generation population based programs randomized trial recruit research study responsible research conduct sample collection service utilization translational study

项目摘要

CORE 011 – SURVEY AND BIOSPECIMEN SHARED RESOUCE PROJECT SUMMARY/ABSTRACT The mission of the Survey and Biospecimen Shared Resource (SBSR) is to provide high-quality survey and laboratory services to support the Vanderbilt-Ingram Cancer Center (VICC) research community, inclusive of our VICC members and partners at Meharry Medical College, Tennessee State University, and other NCI Cancer Centers. This mission is fulfilled through two distinct but complementary functions: survey research services and laboratory services. The survey services include consultation for study design or implementation, survey programming, participant enrollment, computer-assisted telephone interviewing, medical record review and study mailings. The laboratory services include consultation for study design, biospecimen collection, processing, storage and retrieval, DNA/RNA extraction, genotyping, and biomarker assays. The SBSR also manages biorepositories for multiple studies including from three large prospective cohort studies and several large case-control studies. The scientific co-Directors of the SBSR have directed studies involving data and biologic sample collection from more than 200,000 study participants in the United States and abroad. Thus, the SBSR provides VICC members with access to significant expertise and capabilities in large-scale population- based research; avoids the start-up costs associated with hiring and training staff for data collection and sample processing; shares experienced research staff to reduce study costs; implements rigorous quality control protocols; and enables high quality specimen and data collection and processing. The major scientific achievement of the SBSR is reflected in the service utilization and publications. The SBSR supports multiple studies that are recruiting participants, collecting survey data and/or biospecimens, or performing biological assays on collected samples. Twenty-six VICC members have benefited from the services of the resource to improve study design and research quality. VICC members with peer-reviewed support account for 91% and 98% of total service usage for the laboratory services and survey services, respectively. This shared resource has supported the publication of over 200 cancer-related manuscripts published since 2015 including in journals such as JAMA, Nature, Nature Genetics, JNCI and Cancer Research. Through the implementation and sharing of best practices, the SBSR staff demonstrates to users the effectiveness of a rigorous approach to the conduct of population-based research, which enables individual investigators, students, fellows and staff to better incorporate these practices into their research programs. Thus, the SBSR services are critical for the research conducted by VICC members across multiple VICC research programs.

核心 011 – 调查和生物样本共享资源项目概要/摘要调查和生物样本共享资源 (SBSR) 的使命是提供高质量的调查和实验室服务支持范德比尔特-英格拉姆癌症中心 (VICC) 研究社区，包括我们的 VICC 成员以及梅哈里医学院、田纳西州立大学和其他 NCI 癌症中心的合作伙伴这一使命是通过两个不同但互补的职能来实现的：调查研究服务和实验室服务包括研究设计或实施的咨询、调查。编程、参与者登记、计算机辅助电话访谈、医疗记录审查和研究邮件。实验室服务包括研究设计咨询、生物样本收集、 SBSR 还包括处理、存储和检索、DNA/RNA 提取、基因分型和生物标志物测定。管理多项研究的生物样本库，包括三项大型前瞻性队列研究和多项研究 SBSR 的科学联合主任指导了涉及数据和研究的大型病例对照研究。从美国和国外超过 200,000 名研究参与者收集了生物样本。 SBSR 为 VICC 成员提供了在大规模人群中获得重要专业知识和能力的机会基于研究；避免与雇用和培训数据收集和样本人员相关的启动成本处理；共享经验丰富的研究人员以降低研究成本；实施严格的质量控制；协议；并实现高质量的样本和数据收集和处理。 SBSR 的成就体现在服务利用和出版物上。招募、收集调查数据和/或生物样本或进行生物学研究二十六名 VICC 成员已从该资源的服务中受益。获得同行评审支持的 VICC 成员占 91%，并且实验室服务和调查服务分别占总服务使用量的 98%。自 2015 年以来，已支持发表 200 多篇与癌症相关的手稿，其中包括期刊例如 JAMA、Nature、Nature Genetics、JNCI 和 Cancer Research 通过实施和共享。 SBSR 工作人员向用户展示了严格的最佳实践方法的有效性以人群为基础的研究，使个人研究人员、学生、研究员和工作人员能够更好地因此，SBSR 服务对于研究至关重要。由 VICC 成员在多个 VICC 研究项目中进行。