Characterization of Floor Level Aerosol (PM) Exposure and Childhood Asthma

地面气溶胶 (PM) 暴露和儿童哮喘的特征

• 批准号: 7628108
• 负责人: Stuart Lloyd Shalat
• 金额: $ 25.94万
• 依托单位: UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7628108
• 关键词: Adult; Aerosols; Age; Airborne Particulate Matter; Allergens; Area; Asthma; Breathing; Caliber; Canis familiaris; Child; Childhood Asthma; Clinic; Dermatophagoides farinae antigen f 1; Devices; Endotoxins; Enrollment; Environmental Exposure; Exposure to; Felis catus; Floor; Frequencies; Glass; Height; Household; Laboratories; Life; Measurement; Measures; Methods; Molds; Monitor; Mus; Neighborhoods; Parents; Particle Size; Particulate; Pesticides; Play; Protocols documentation; Questionnaires; Reporting; Robotics; Sampling; Slide; Symptoms; Testing; Time; Toddler; age group; air sampling; cockroach allergen; computerized; early childhood; environmental particulate; experience; fungus; improved; instrument; monitoring device; particle; prototype; pyroglyphid; research study

DESCRIPTION (provided by applicant): A research study is proposed to refine and evaluate a new device to improve the estimation of indoor exposure to inhalable particulate for both children in the first year of life and toddlers. Because they frequently play on the floor, these children may experience significantly higher levels of exposure than older children and adults to PM10 particles and airborne constituents, which are known asthmagens. A total of 200 children ages 6 to 35 months will be enrolled from neighborhood clinics. Parents will be administered a standardized asthma questionnaire (ISAAC) to determine presence and frequency of asthma symtpoms. Exposures will be characterized both qualitatively and quantitatively, to examine if the more precise estimation of PM10 exposure obtained by using a surrogate for personal monitoring. The study will employ a revised iteration of a prototype Pre-Toddler Inhalable Particulate Environmental Robotic (PIPER) Sampler that has been developed and undergone preliminary testing. Sampling will be carried out with both a fixed height stationary sampling station, where inlets of all instruments will be at 110 cm height, and the self- propelled computerized PIPER sampler, where inlets of all instruments can be varied between 20 to 110cm above the floor to mirror the varied breathing heights of these children while engaged in play on the floor. Four parameters will be for each household: 1) mass concentration of PM10 particles measured by a real- time monitoring device; 2) real-time particle size and number distribution (0.3-10 urn); 3) air sampling on filters for detailed characterization of the PM10 constituents (pesticides, allergens, and endotoxins); 4) concentration and composition of airborne fungi (viable and non-viable) collected on glass slides. Measurements will be collected in tandem for each of the 4 types of monitoring. The results of the laboratory analysis for endotoxins, molds and allergens for cockroaches (Bla g Yz), dust mites (Der f 1/p 1), dog (Can f 1), cat (Pel d 1) and mouse (Mus ml) will be evaluated for association with reporting of asthma symptoms This study seeks to provide an alternative to personal monitoring for a variety of environmental exposures that may be experienced by children too young to be assessed by conventional methods, including those in their first year of life. In addition, it will open up an avenue for more precise estimation of early childhood exposures to asthmagens in the PM10 fraction of aerosols.

描述（由申请人提供）：拟开展一项研究，以改进和评估一种新设备，以改进对一岁儿童和幼儿室内可吸入颗粒物暴露的估计。由于经常在地板上玩耍，这些儿童可能比年龄较大的儿童和成人更容易接触 PM10 颗粒和空气中的成分（已知的哮喘原）。社区诊所将招募总共 200 名 6 至 35 个月大的儿童。家长将接受标准化哮喘问卷 (ISAAC) 以确定哮喘症状的存在和频率。将对暴露进行定性和定量表征，以检查是否通过使用个人监测替代物来获得对 PM10 暴露的更精确估计。该研究将采用经过改进的幼儿可吸入颗粒环境机器人 (PIPER) 采样器原型，该采样器已开发并经过初步测试。采样将使用固定高度固定采样站（所有仪器的入口高度为 110 厘米）和自走式计算机化 PIPER 采样器（所有仪器的入口高度可在距地面 20 至 110 厘米之间变化）进行。反映这些孩子在地板上玩耍时不同的呼吸高度。每户有四个参数：1）实时监测装置测量的PM10颗粒质量浓度； 2) 实时粒径及数量分布（0.3-10瓮）； 3) 对过滤器进行空气采样，以详细表征 PM10 成分（农药、过敏原和内毒素）； 4) 载玻片上收集的空气真菌（活的和非活的）的浓度和成分。将为 4 种类型的监测中的每一种类型同时收集测量结果。蟑螂 (Bla g Yz)、尘螨 (Der f 1/p 1)、狗 (Can f 1)、猫 (Pel d 1) 和小鼠 (Mus ml) 内毒素、霉菌和过敏原的实验室分析结果将评估与哮喘症状报告的关联本研究旨在提供一种替代个人监测的方法，以监测因年龄太小而无法通过传统方法评估的儿童可能经历的各种环境暴露，包括那些在环境中暴露的儿童。他们生命的第一年。此外，它还将为更精确地估计幼儿接触气溶胶中 PM10 成分中的哮喘物质开辟一条途径。