HIV-1 SUBTYPE C FITNESS EVOLUTION AND MOTHER TO CHILD TRANSMISSION

HIV-1 C 亚型健康进化和母婴传播

• 批准号: 7725291
• 负责人: JOHN WEST
• 金额: $ 6.93万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7725291
• 关键词: Amino Acids; Computer Retrieval of Information on Scientific Projects Database; Evaluation; Evolution; Funding; Genetic Polymorphism; Grant; HIV Envelope Protein gp120; Institution; Outcome; Physiologic pulse; Process; Pulse taking; Research; Research Personnel; Resources; Source; System; United States National Institutes of Health; Vertical Disease Transmission; Virus; fitness

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The significance of our current findings is that they demonstrate that the fluorescent viruses are infectious and thus will be excellent platforms for carrying out the fitness evaluations proposed. Moreover the finding that in our pulse chase analyses that there are significant alterations in processing and in gp120 shedding is almost certain to have impact on the outcome of other phenotypic evaluations such as incorporation and fusion. These parameters, in turn will impact fitness. Therefore it seems likely that the system will detect fitness differences and those differences will be attributable to amino acid polymorphisms between different C2-V4 regions.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们当前研究结果的意义在于，它们证明荧光病毒具有传染性，因此将成为进行所提出的适应性评估的绝佳平台。此外，我们的脉冲追踪分析发现，处理过程和 gp120 中存在显着变化 脱落几乎肯定会对其他表型评估的结果产生影响，例如掺入和融合。这些参数反过来会影响健康。因此，系统似乎可能会检测适应性差异，而这些差异将归因于氨基酸多态性 不同的C2-V4区域之间。