HIV-1 SUBTYPE C FITNESS EVOLUTION AND MOTHER TO CHILD TRANSMISSION

HIV-1 C 亚型健康进化和母婴传播

• 批准号: 7959340
• 负责人: JOHN WEST
• 金额: $ 12.87万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959340
• 关键词: Biological Assay; Biological Models; Computer Retrieval of Information on Scientific Projects Database; Development; Disadvantaged; Evolution; Funding; Genome; Glycoproteins; Grant; HIV-1; Individual; Infection; Institution; Molecular; Proteomics; Research; Research Personnel; Resources; Source; System; United States National Institutes of Health; Vaccinated; Vertical Disease Transmission; fitness; in vitro Model; pathogen; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The significance of our findings is that we have developed and implemented a system to quantifiably evaluate the fitness advantages or disadvantages imparted by specific envelope glycoprotein sequences. This was done either over the course of infection within a single individual or in transmission pairs. We have also begun to develop in vitro model system to define the molecular determinants of fitness in transmission and in replicative assays. Our result should help to refine the development of strategies to vaccinate against the HIV-1 glycoprotein by identifying rational targets with pathogenetic significance.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们的研究结果的意义在于，我们开发并实施了一个系统来量化评估特定包膜糖蛋白序列所带来的适应性优势或劣势。这是在单个个体或传播对的感染过程中完成的。我们还开始开发体外模型系统来定义传播和复制测定中适应性的分子决定因素。我们的结果应该有助于通过确定具有致病意义的合理靶标来完善针对 HIV-1 糖蛋白的疫苗接种策略的制定。