Patient-Oriented Research and Mentoring Program in Prematurity-Associated Pulmonary Morbidity

以患者为中心的早产儿相关肺部疾病研究和指导计划

基本信息

批准号：
10004719
负责人：
Anna Maria Hibbs
金额：
$ 11.96万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10004719
关键词：
2 year old Age Age-Months Apnea Breathing Clinical Clinical Research Data Degree program Development Developmental Delay Disorders Diet Dietary intake Disease Dose Enrollment Event Faculty Family Follow-Up Studies Frequencies Funding Future Goals Hospitalization Hypersensitivity Hypoxia Immune system Impairment Infant Intervention Lead Life Link Lung Measurable Measures Medical Mentors Mentorship Morbidity - disease rate Multicenter Studies Outcome Oxidative Stress Oxygen Oxygen Therapy Care Pathway interactions Pediatric Hospitals Population Pregnancy Premature Birth Premature Infant Protocols documentation Provider Questionnaires Recurrence Regimen Research Research Personnel Respiration Respiration Disorders Retinopathy of Prematurity Role Serotonin Site Sleep Sleep Apnea Syndromes Structure Supplementation Symptoms Techniques Testing Time Training Programs Vitamin D Vitamin D supplementation Wheezing animal data atopy case control clinically relevant cohort comparative effectiveness experience falls follow-up high risk human data immune function lung injury meetings neonatal lung injury neonatal period novel oxidant stress patient oriented research premature prevent programs pulmonary function racial difference respiratory respiratory morbidity response time interval

项目摘要

PROJECT SUMMARY Dr. Hibbs proposes a patient-oriented research and mentorship program focusing on prematurity-associated pulmonary morbidity. She has a strong track-record for POR research and mentorship and availability of future mentees from junior faculty and trainees at Rainbow Babies and Children's Hospital (RBC) and CWRU; she will integrate mentees in the newly proposed project as well as other currently funded local and multi-center studies. Longer term respiratory morbidity and neurodevelopmental delay are major consequences of preterm birth. In the proposed study, we seek to characterize the association between immature respiratory control, manifesting as intermittent hypoxia (IH), and later respiratory and neurodevelopmental morbidity in a cohort of preterm infants less than or equal to 30 weeks' gestation. This proposal is a two-year follow-up study of the Pre-Vent Case Western Reserve (CWRU) site protocol, and represents a unique opportunity to pair longer-term clinically relevant outcomes, as measured by validated questionnaires, with an already-funded study using sophisticated techniques to capture and analyze early life IH events. Our hypotheses are that IH episodes at one week and one month of life are significantly associated with recurrent wheezing, sleep disordered breathing, and neurodevelopmental delay. In prior studies we have demonstrated that apnea almost always precedes desaturation in preterm infants and have documented a novel association between retinopathy of prematurity, and both the duration of IH events and the time interval between IH events. From these data we speculate that it is not only longer and more frequent IH events, but also distinct time interval of at least one minute between IH events, that will be associated with long-term clinical morbidities. We provide additional retrospective data that IH is associated with wheezing disorders, as well as a remarkable track record for both meeting enrollment goals and effective follow-up in prior clinical studies.

项目概要希布斯博士提出了一项以患者为中心的研究和指导计划，重点关注与早产相关的肺部疾病。她在 POR 研究方面拥有良好的记录 Rainbow 的初级教师和实习生对未来学员的指导和可用性婴儿和儿童医院 (RBC) 和 CWRU；她将把受训者融入新的环境中拟议的项目以及其他目前资助的本地和多中心研究。长期呼吸系统疾病和神经发育迟缓是主要后果早产。在拟议的研究中，我们试图描述不成熟之间的关联呼吸控制，表现为间歇性缺氧（IH），随后出现呼吸和呼吸困难小于或等于 30 周的早产儿队列的神经发育发病率妊娠。该提案是对 Pre-Vent Case Western Reserve 的两年跟踪研究（CWRU）现场协议，代表了一个独特的机会来配对长期临床相关的结果，通过经过验证的调查问卷进行衡量，并使用一项已经资助的研究捕捉和分析早期生活 IH 事件的复杂技术。我们的假设是 IH 出生后一周和一个月的发作与复发显着相关喘息、睡眠呼吸障碍和神经发育迟缓。在之前的研究中我们有证明早产儿呼吸暂停几乎总是发生在饱和度降低之前，并且记录了早产儿视网膜病变与 IH 持续时间之间的新关联事件和 IH 事件之间的时间间隔。从这些数据我们推测，这不仅是更长、更频繁的 IH 事件，但也有至少一分钟的明显时间间隔 IH 事件之间的差异将与长期临床发病率相关。我们提供其他回顾性数据表明 IH 与喘息性疾病相关，以及在满足入组目标和先前临床中的有效随访方面具有出色的记录研究。