Project-002

项目-002

基本信息

批准号：
10004134
负责人：
MARC D. BASSON
金额：
$ 18.19万
依托单位：
UNIVERSITY OF NORTH DAKOTA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10004134
关键词：
Accounting Address Advocate Affect Age American Indians Applications Grants Area Biology Biomedical Research Biometry Cancer Biology Caring Cause of Death Center for Translational Science Activities Centers of Research Excellence Cessation of life Clinical Clinical Investigator Clinical Research Communities Community Health Community Medicine Core Facility Data Development Diagnosis Disease Surveillance Educational Curriculum Ensure Environment Epidemiology Epigenetic Process Evaluation Faculty Family Practice Funding Goals Government Grant Growth Health Health Promotion Health Sciences Home environment Hospitals Human Incidence Individual Infrastructure Institution Intervention Lead Link Malignant Neoplasms Methods NCI Center for Cancer Research Nature Neoplasm Metastasis Neurodegenerative Disorders North Dakota Outcome Pathway interactions Patients Physicians Physiology Pilot Projects Population Population Study Positioning Attribute Prevalence Process Research Research Design Research Personnel Research Project Grants Research Training Resources Rivers Rural Health Rural Health Centers Science Scientist Site Social Class South Dakota State Hospitals Suggestion System Testing Time Training Translating Translational Research Treatment Cost Universities Woman Work anticancer research base clinically relevant combat cost effectiveness design effective therapy epidemiology study immunoregulation improved innovation interdisciplinary approach investigator training medical schools men mortality novel outreach outreach program patient safety population based population health programs recruit research facility rural Americans social health determinants socioeconomics success translational cancer research translational scientist tumor progression volunteer

项目摘要

Summary: The objective of this grant application is to create a center to support and expand our ability to conduct full-spectrum clinical and translational research on various cancers. Establishing the Dakota Cancer Collaborative on Translational Activity (DACCOTA) will also allow us for the first time to apply our basic scientific and epidemiologic work to the clinical arena while training clinician-investigator partners to translate these discoveries. We will train basic scientists to conduct translational work, population health experts to understand the community determinants of cancer outcomes, and clinicians to collaborate. The DACCOTA will promote and facilitate interactions between clinicians and scientists with unique but complementary areas of expertise. Our goal is to develop a highly productive, collaborative, and sustainable translational research center that will focus on the cancers that most commonly and disproportionately afflict the citizens of our region, especially American Indians. We have proposed independent cores, all led by capable investigators, that will assist in building a competitive clinical and translational cancer research center. The DACCOTA will provide an academic home for clinical and translational scientists and trainees. These investigators will focus on understanding the mechanisms leading to the initiation and progression of cancer, which will facilitate the development of novel and effective treatments and improve disease surveillance. This is necessary due to the increase in cancer prevalence and mortality in the Dakota region and throughout the USA. The DACCOTA will have further impact by validating new ways of developing and supporting individuals to facilitate team-based science addressing critical issues affecting the region. Our Professional Development Core will develop aspiring investigators and train practicing "real world“ clinicians to become more avid and effective collaborators. Applicants for pilot grants will be required to propose teams including an investigator and clinician. The Community Enagement and Outreach Core will help recruit volunteers, seek advice about overall directions, and work with community leaders to designate specific cancer-related issues of community concern for RFA’s that will be funneled through the Pilot Projects Program. In addition to the community-based natures of the University of North Dakota (UND), North Dakota State University (NDSU), and the University of South Dakota (USD), the collaborating hospitals in this proposal cover more than 90% of the region and include multiple innovative departments of family and community medicine as well as rural and population health. There are also three MPH programs between these institutions. Thus, we are superbly positioned to conduct clinical research encompassing the entire region. Similarly, the Biostatistics, Epidemiology, and Research Design Core and the Clinical Research Resources and Facilites Core will combine their strengths and develop new resources to enhance clinical research. Finally, our Tracking and Evaluation Core will use innovative methods to evaluate these novel processes as well as provide suggestions to improve efficiency and ensure both cost-effectiveness and improved patient safety. UND, NDSU, USD, and all clinical partners are fully committed to ensuring the growth and sustainability of the DACCOTA even after the CTR grant ends.

摘要：本赠款申请的目的是创建一个中心，以支持和扩大我们的能力对各种癌症进行全光谱临床和翻译研究。建立达科他州癌症转化活动的合作（DACCOTA）也将使我们首次应用我们的在培训临床评估伙伴的同时，向临床领域的基本科学和流行病学工作翻译这些发现。我们将培训基本科学家进行转化工作，人口健康了解社区的专家确定癌症结果，而临床医生则进行合作。这 DACCOTA将促进和促进具有独特但具有独特但科学家之间的互动完全专业领域。我们的目标是开发高产，协作性和可持续转化研究中心将重点关注最常见的癌症不成比例地折磨着我们地区的公民，尤其是美国印第安人。我们提出了独立核心，都是由能干的调查员领导的，这将有助于建立竞争激烈的临床和翻译癌症研究中心。 Daccota将为临床和翻译科学家和学员。这些调查人员将专注于理解机制导致癌症的主动性和进展，这将促进新颖和新颖的发展有效治疗并改善疾病监测。由于癌症的增加，这是必要的达科他州和整个美国的患病率和死亡率。 daccota将进一步通过验证开发和支持个人促进基于团队科学的新方法来影响解决影响该地区的关键问题。我们的专业发展核心将发展有抱负调查人员和火车实践“现实世界”临床医生变得更加狂热，有效。将需要提出包括调查员和临床在内的团队提出飞行员赠款的申请人。这社区振兴和宣传核心将有助于招募志愿者，寻求有关整体的建议方向，并与社区领导人合作，指定社区与癌症相关的特定问题对RFA的关注将通过试点项目计划而进行。除了基于社区的北达科他大学（UND），北达科他州立大学（NDSU）和南达科他大学（USD），该提案中的合作医院涵盖了90％以上地区，包括家庭和社区医学以及农村的多个创新部门人口健康。这些机构之间还有三个MPH程序。那我们很棒定位进行临床研究，包括整个地区。同样，生物统计学，流行病学以及研究设计核心以及临床研究资源和设施核心将结合优势并开发新的资源来增强临床研究。最后，我们的跟踪评估核心将使用创新方法来评估这些新型过程并提供提高效率并确保成本效益和改善患者安全的建议。 und，， NDSU，USD和所有临床合作伙伴都完全致力于确保增长和可持续性 Daccota即使在CTR赠款结束后。