Wireless Sensors for Functional MRI of Brain Seizures

用于大脑癫痫发作功能 MRI 的无线传感器

• 批准号: 10002216
• 负责人: Aviad Hai
• 金额: $ 17.28万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10002216
• 关键词: 3-Dimensional; Address; Animals; Architecture; Area; Biophysics; Blood; Blood Volume; Blood flow; Brain; Brain Diseases; Brain Injuries; Brain imaging; Cannulas; Catheters; Cell Culture Techniques; Cell physiology; Cells; Cerebral cortex; Chemical Stimulation; Chemicals; Clinical; Computer Models; Contrast Media; Corpus striatum structure; Coupled; Data; Development; Devices; Diagnosis; Diagnostic; Disease; Distal; Doctor of Philosophy; Electric Capacitance; Electric Stimulation; Electrodes; Electromagnetic Fields; Electron Beam; Elements; Engineering; Epilepsy; Event; Frequencies; Functional Imaging; Functional Magnetic Resonance Imaging; Geometry; Hippocampus (Brain); Hydrogen; Image; In Vitro; Institution; Magnetic Resonance Imaging; Measurement; Measures; Medicine; Mentors; Methods; Modeling; Monitor; Neurobiology; Neurologic; Neurologic Symptoms; Neurologist; Neuronal Dysfunction; Neurons; Neurosciences; Noise; Pathologic; Pattern; Peptides; Performance; Physiological; Physiological Processes; Positioning Attribute; Principal Investigator; Process; Property; Publishing; Rattus; Reporting; Research; Research Personnel; Research Project Grants; Resolution; Risk; Rodent; Rodent Model; Scientist; Seizures; Semiconductors; Signal Transduction; Site; Techniques; Technology; Testing; Tetanus Toxin; Transistors; Traumatic Brain Injury; United States National Institutes of Health; Validation; Wireless Technology; Work; base; blood oxygen level dependent; contrast imaging; design; electrical property; experimental study; imaging agent; imaging modality; imaging probe; implantation; improved; in vivo; innovation; magnetic field; metal oxide; millimeter; minimally invasive; multidisciplinary; nanoengineering; nanolithography; neuroimaging; neurovascular; non-invasive monitor; noninvasive diagnosis; novel; novel diagnostics; relating to nervous system; response; sensor; simulation software; spatiotemporal; technology validation; tool; voltage

Project Summary The central aim of this NIH K01 mentored research project is the development of a new type of wireless microelectronic sensors for direct functional magnetic resonance imaging (fMRI) of brain seizures. fMRI has emerged in the past two decades as a prominent tool for noninvasive diagnosis and monitoring of neuropathological disorders and brain injury. However, it relies on blood oxygen level-dependent (BOLD) signal, which is mainly of neurovascular origin and is a fundamentally indirect manifestation of neural activity. This precludes the distinction between inhibitory and excitatory neural activity, risking false positives and false negatives in the diagnosis and monitoring of brain seizures. In this project, the mentored investigator will combine his expertise in microelectronic probes for the recording of neural activity, and combine them with neuroimaging capabilities of the host institution, to develop wireless MRI sensors to uniquely and specifically address questions of temporal and cross-regional manifestations of pathological brain patterns in rodent models of epilepsy. This new form of brain imaging will allow for the acquisition of direct readouts of seizures using MRI, employing its three-dimensional encoding capabilities to study abnormal firing patterns and neural dysfunction across the brain. The research proposed here represents an initial step in a new and innovative field for neuroscience and neurological research for the treatment of brain diseases. The novel methods propose here by the mentored scientist will be broadly applicable to problems in neurobiology, and will transform the ability of neuroscientists to study integrative functions of the brain in neuropathological disorders. The approach will also help to establish a new path in diagnostic medicine whereby responsive microfabricated active devices drive the change in MRI contrast similarly to conventional chemical contrast agents, and can report on aspects of cellular physiology for functional MRI. Aviad Hai, PhD, will serve as principal investigator for this project. Dr. Hai is a neurobiological engineer that focuses on the development and application of novel sensors for neuroimaging and brain recording.. Dr. Hai has made several key contributions in the development of new diagnostic imaging agents for studying physiological processes in the brain using MRI in rodents, as well as the development nano-engineered probes for recording and stimulation of brain activity. His extensive expertise and published contributions in both the microelectronic engineering and imaging portions of the project put him at a natural position of leading this highly multidisciplinary mentored project. Dr. Hai will direct efforts of microelectronic fabrication, in-vitro and in-vivo validation in animals, all of which are within his expertise.

项目摘要 该NIH K01指导研究项目的核心目的是开发一种新型的无线无线 用于脑癫痫发作的直接功能磁共振成像（fMRI）的微电源传感器。 fMRI有 在过去的二十年中，出现了无创诊断和监测的重要工具 神经病理障碍和脑损伤。但是，它依赖于血氧水平依赖性（粗体） 信号主要是神经血管起源，是神经活动的根本间接表现。 这排除了抑制性和兴奋性神经活动之间的区别，冒着误报和虚假的风险 诊断和监测脑癫痫发作的负面因素。在这个项目中，指导的调查员将 结合他在微电子探针中的专业知识，以记录神经活动，并将其与 主机机构的神经影像学能力，开发无线MRI传感器以唯一，特别是 解决啮齿动物中病理大脑模式的时间和跨区域表现的问题 癫痫的模型。这种新形式的大脑成像将允许收集直接癫痫发作 使用MRI，采用其三维编码功能来研究异常射击模式和神经 整个大脑的功能障碍。这里提出的研究代表了新的创新性的第一步 神经科学和神经学研究领域的治疗脑疾病。新方法 这位导师的科学家在这里提出的建议将广泛适用于神经生物学的问题，并将 改变神经科学家研究大脑在神经病理疾病中的综合功能的能力。 该方法还将有助于建立诊断医学的新途径，从而响应微型制动 主动设备可以使MRI的变化与常规化学对比剂相似，并且可以 有关功能性MRI的细胞生理学方面的报告。 Aviad Hai博士将担任首席研究员 对于这个项目。 Hai博士是一位神经生物学工程师，专注于新颖的发展和应用 神经影像和大脑记录的传感器。 新的诊断成像剂用于研究啮齿动物中MRI研究大脑中的生理过程 以及用于记录和刺激脑活动的纳米工程探针。他的广泛 专业知识和发表的贡献在微电子工程和成像部分中的贡献 项目使他处于领导这个高度学科的指导项目的自然位置。海博士将导演 在动物中，微电体制造，体外和体内验证的努力，所有这些都在他的内部 专业知识。