Implantable Nanophotonic Sensors for in Vivo Immunoresponse

用于体内免疫反应的植入式纳米光子传感器

基本信息

批准号：
10002722
负责人：
Mekhail Anwar
金额：
$ 242.25万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-10 至 2025-06-30
项目状态：
未结题

项目摘要

PROJECT SUMMARY Visualizing real-time physiologic and molecular tumor response to targeted molecular agents and radiation, within the complex in situ host environment - in effect a wireless biopsy - provides a heretofore unseen window into cancer biology, guiding optimal, personalized patient care. We aim to develop a versatile platform imaging the dynamic immune response within the patient’s tumor microenvironment. Here we introduce a first-in-class, fully implantable, wireless, microfabricated electronic-photonic platform for real-time in vivo tumor monitoring. This platform can be utilized with any tumor type as well as non-oncologic applications where biomarkers are essential. The platform will provide the full functionality of a fluorescence microscope, in a millimeter-scale implantable sensor. in vivo microscopy enables intratumoral fluorescent imaging, leveraging an armamentarium of existing targeted biologics unveiling both tumor biology within the complex host environment and early indicators of tumor response. We will detect and explore the role of the immune response at the site of disease dramatically increasing sensitivity while providing spatial localization - key to unlocking a systemic effect. Made possible by recent innovations in wireless power and data transfer, and unprecedented integration of high-speed circuits with photonics, these advances will unlock an entirely new paradigm of real- time response assessment enabling effective application of novel therapeutics and immunotherapy, customized to patient’s tumor biology.

项目概要可视化对靶向分子制剂和辐射的实时生理和分子肿瘤反应，在复杂的原位宿主环境中 - 实际上是无线活检 - 提供了一个迄今为止未见过的窗口我们的目标是开发一个多功能成像平台。患者肿瘤微环境中的动态免疫反应在这里我们推出了一流的、完全植入式、无线、微加工电子光子平台，用于实时体内肿瘤监测。该平台可用于任何肿瘤类型以及生物标记物的非肿瘤应用。该平台将提供毫米级荧光显微镜的全部功能。植入式传感器利用体内显微镜实现肿瘤内荧光成像。现有靶向生物制剂的军备库揭示了复杂宿主环境中的肿瘤生物学我们将检测并探索该部位免疫反应的作用。疾病的敏感性显着提高，同时提供空间定位——解锁系统性的关键无线电力和数据传输方面的最新创新使这种效果成为可能，而且是前所未有的。高速电路与光子学的集成，这些进步将开启一个全新的实时范例时间反应评估能够有效应用新型疗法和免疫疗法，根据患者的肿瘤生物学定制。