FOX CORE Phase II Research Core #1 Synthesis

FOX CORE 二期研究核心

• 批准号: 10026271
• 负责人: Donald Allen Watson
• 金额: $ 14.99万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10026271
• 关键词: Advisory Committees; Analytical Chemistry; Biological Process; Biomedical Research; Budgets; Cell Culture Techniques; Centers of Research Excellence; Charge; Chemicals; Chemistry; Core Facility; Custom; Delaware; Development; Doctor of Philosophy; Electronics; Engineering; Equipment; Faculty; Foxes; Future; Goals; Growth; Industrialization; Infrastructure; Intellectual Property; Laboratories; Lead; Libraries; Maintenance; Microscopy; Mission; Modeling; Molecular; Phase; Policies; Publications; Reaction; Reporting; Research; Research Personnel; Resource Sharing; Schedule; Scientist; Services; Specialist; Synthesis Chemistry; Therapeutic; assay development; base; catalyst; computing resources; data management; experience; instrument; instrumentation; recruit; small molecule

Project Summary Synthesis and Discovery Core This Phase II COBRE will continue on its mission to focus a diverse team of scientists on the discovery of new molecules that probe the function of biological targets. During Phase I, our COBRE developed an instrumentation core, unique to the state of Delaware, that enabled molecular discovery, purification and analysis. The growth of our center and the breadth of services offered through our core facilities have prompted us to reorganize this instrumentation into two core facilities for Phase II: the Synthesis and Discovery (SD) Core Facility and the Analytical Chemistry Core Facility. The proposed Synthesis and Discovery (SD) Core Facility consists of instrumentation and infrastructure for small molecule synthesis, high throughput catalyst discovery, computation and microscopy capabilities that will continue to be broadly used by researchers across the IDeA network and beyond. During Phase II, we will expand the scope of the facility to provide chemistry services to non-specialists across the biomedical research spectrum. The facility will enable biologists, biochemists, engineers, and others access to custom synthesis of molecules they cannot easily make them themselves. The goals of the SD Core Facility will include (1) the development of an administrative framework for the facility and the recruitment of staff to provide core services, and (2) establishment of a Custom Synthesis Laboratory (CSL) that will provide a broad array of synthetic services including small molecule synthesis, purification, chemical assay development and high throughput reaction development and parallel synthesis.

项目摘要 合成和发现核心 这一第二阶段的鞋垫将继续其使命，将一群多样的科学家团队集中在发现新的方面 探测生物靶标的功能的分子。在第一阶段，我们的毛病开发了一种仪器 核心，特拉华州独有的核心，可以使分子发现，纯化和分析。增长 我们的中心和通过我们的核心设施提供的服务广度促使我们重组了这一点 仪器分为第二阶段的两个核心设施：综合与发现（SD）核心设施和 分析化学核心设施。拟议的合成与发现（SD）核心设施包括 小分子合成，高吞吐量催化剂发现，计算的仪器和基础设施 和显微镜功能，研究人员将继续在整个想法网络和 超过。在第二阶段，我们将扩大设施的范围，以向非专家提供化学服务 在整个生物医学研究范围内。该设施将使生物学家，生物化学家，工程师和其他人能够 访问分子的自定义合成，它们无法轻易使它们自己制造。 SD核心的目标 设施将包括（1）为设施和招募人员的行政框架开发 提供核心服务，以及（2）建立定制合成实验室（CSL），该实验室将提供广泛的 一系列合成服务，包括小分子合成，纯化，化学测定开发和 高吞吐量反应发展和平行合成。