Fox COBRE Phase II Admin Core

Fox COBRE 第二阶段管理核心

基本信息

批准号：
10026269
负责人：
JOSEPH M FOX
金额：
$ 68.61万
依托单位：
UNIVERSITY OF DELAWARE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10026269
关键词：
Achievement Adjuvant Advisory Committees Area Award Biological Biology Biomedical Research Capsid Career Mobility Cells Centers of Research Excellence Chemicals Communicable Diseases Core Facility Development Disease Educational workshop Enzymes Event Faculty Foxes Funding Goals Grant Group Meetings Growth Growth and Development function HIV Human Human Biology Immune response Immunology Infrastructure Lead Leadership Legionnaires&apos Disease Link Lung Macromolecular Complexes Malignant Neoplasms Manuscripts Maps Mentors Messenger RNA Microbiology Modeling Modification Molecular Molecular Probes Pathway interactions Phase Pilot Projects Postdoctoral Fellow Preparation Publications Regulation Research Research Personnel Research Training Resources Series Structure Students Therapeutic Tuberculosis Universities Virus Vocational Guidance Work Writing career development chemical synthesis cohort drug discovery endopeptidase Clp experience faculty mentor flexibility formative assessment human disease meetings member nanoparticle pathogenic bacteria programs recruit research and development small molecule success support network tool vaccine development

项目摘要

Project Summary Administrative Core This Phase II COBRE will continue our center’s work to develop molecular approaches for probing biology, to discover and apply new chemical biology tools for the study of biological pathways associated with disease, and to develop computational approaches for understanding small molecule interactions with complex macromolecular targets. Building on the infrastructure and successes of Phase I, our COBRE will develop new chemical biology tools for understanding the cellular and molecular mechanisms that bacterial pathogens use to survive and replicate inside host cells, molecular probes that can be used to understand Clp protease targets of infectious diseases, tools to map and understand the regulation of reversible mRNA modification by a ‘methyl eraser’ enzyme linked to the progression of human cancers, molecularly-defined nanoparticle adjuvants that yield specific immune responses in the lung to advance inhalable vaccine development, and computational approaches to elucidate the mechanisms by which small molecules regulate the structure and function of virus capsids. The goals of the Administrative Core are (1) Development of the administrative, fiscal and scientific aspects of the proposed COBRE, including establishment of a leadership team and a hiring plan; (2) Implementation of summative and formative evaluation strategies by the Leadership Team, an Internal Advisory Committee (IAC), mentors, and an External Advisory Committee (EAC); (3) Implementation of a Career Guidance Plan that enables faculty to develop successful research programs and to attract funding for their work; (4) Development of research, training & career development goals and capabilities. A plan for hiring and retaining successful faculty is detailed as is a plan for transitioning investigators to independent status with continued access to core facilities and participation in COBRE sponsored events.

项目摘要行政核心这一第二阶段的鞋垫将继续我们中心的工作，以开发探测生物学的分子方法，发现并应用新的化学生物学工具来研究与疾病相关的生物学途径，开发用于理解与复杂分子相互作用的计算方法大分子靶标。在第一阶段的基础设施和成功的基础上，我们的毛病将开发新的化学生物学工具，用于了解细菌病原体使用的细胞和分子机制在宿主细胞内生存和复制，可用于了解CLP蛋白酶靶标的分子问题传染病，绘制和理解可逆mRNA修饰的工具橡皮擦的酶与人类癌的进展有关，分子定义的纳米粒子调节器在肺部产生特定的免疫反应以推动吸入疫苗的开发和计算阐明小分子调节病毒结构和功能的机制的方法衣壳。行政核心的目标是（1）发展行政，财政和科学方面拟议中的毛茸茸，包括建立领导团队和招聘计划；（2）实施领导团队，内部咨询委员会（IAC）的总结和形成性评估策略，导师和外部咨询委员会（EAC）；（3）实施职业指导计划使教师能够制定成功的研究计划并吸引他们的工作资金；（4）发展研究，培训和职业发展目标和能力。雇用和保留成功的计划教师详细介绍了将调查人员转变为独立身份的计划，并继续访问核心设施和参与毛绒赞助的活动。